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A kind of antibacterial chlorhexidine acetate nanoemulsion mouthwash and preparation method thereof

A technology of chlorhexidine acetate and nanoemulsion, which is applied in the field of medicine, can solve problems such as death, and achieve the effects of good biocompatibility, good stability, and good stability

Active Publication Date: 2018-04-27
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Serious side effects of death when used as a vaginal douche

Method used

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  • A kind of antibacterial chlorhexidine acetate nanoemulsion mouthwash and preparation method thereof
  • A kind of antibacterial chlorhexidine acetate nanoemulsion mouthwash and preparation method thereof
  • A kind of antibacterial chlorhexidine acetate nanoemulsion mouthwash and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: Chlorhexidine acetate nanoemulsion mouthwash (100g)

[0062] 1) Weigh 0.5g of chlorhexidine acetate, 4.8g of propylene glycol, 19.6g of Tween-80, 6g of IPM, 0.1g of natural mint, and 69g of distilled water.

[0063] 2) Mix the amount of surfactant, co-surfactant and chlorhexidine acetate, and stir with a constant temperature magnetic stirrer at a speed of 50 to 100 r / m to completely dissolve the chlorhexidine acetate;

[0064] 3) Add the amount of oil phase in a constant temperature water bath at 25°C, stir with a constant temperature magnetic stirrer at a rotating speed of 100-200r / m, and slowly add about 70% of the prescription amount of distilled water to obtain a clear solution;

[0065] 4) The mouth freshener natural peppermint of said amount is dissolved in water, or peppermint oil and menthol are dissolved in propylene glycol and then added in the prescription.

[0066] 5) Slowly add distilled water to the prescribed amount at 20°C to 25°C and stir...

Embodiment 2

[0070] Weigh 0.5g of chlorhexidine acetate, 15g of propylene glycol, 30g of Tween-80, 20g of medicinal IPM, 0.05g of natural mint, and 34.45g of distilled water.

Embodiment 3

[0072] Weigh 0.5g of chlorhexidine acetate, 5g of glycerin, 30g of Tween-85, 4g of Span-80, 10g of medicinal IPM, 0.05g of natural borneol, and 50.45g of distilled water. The preparation method is the same as in Example 1.

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Abstract

The invention provides an antibacterial chlorhexidine acetate nanoemulsion mouthwash and a preparation method thereof. The nanoemulsion mouthwash of the present invention is made of the following raw and auxiliary materials in parts by weight: 0.2-1.5 parts of chlorhexidine acetate, 8-30 parts of surfactant, 4-15 parts of co-surfactant, and 3-20 parts of oil phase , 0.05-1 part of oral freshener, 34.45-69.0 parts of distilled water. The nanoemulsion mouthwash of the present invention can significantly improve its solubility, and its quality is extremely stable, especially through the destruction of cell membranes, it has obvious antibacterial effect on Streptococcus mutans represented by oral pathogenic bacteria, etc. in vivo and in vitro. The product of the invention is convenient to use, low in cost, remarkable in curative effect, does not contain alcohol, is safe, non-toxic, non-irritating, has no side effects, and does not produce drug resistance, and is an article for oral cavity sterilization, disinfection and cleaning. It can be widely used in periodontitis, gingivitis, oral ulcers, dental plaque, bleeding teeth, bad breath and other oral diseases.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a nanoemulsion mouthwash capable of treating oral diseases, in particular to an antibacterial chlorhexidine acetate nanoemulsion mouthwash and a preparation method thereof. Background technique [0002] Because the environment in the oral cavity (humidity, temperature and nutritional status) is particularly suitable for the growth and reproduction of microorganisms, the oral cavity is the part with the largest number of microorganisms in the human body. Studies have shown that there are 10 billion bacteria in every gram of tartar (tartar) of normal healthy people, and the bacteria in the oral cavity are much more than the number on the skin surface. Therefore, if the oral cavity is not cleaned in time, it will cause bad breath, inflammation of the gums, oral ulcers, tooth decay, and periodontal disease, which will seriously endanger people's health. Oral cleaning becomes the first step in p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/43A61K8/34A61Q11/00A61P1/02A61P31/02
Inventor 孙红武刘开云李云飞李世音郭刚邹全明
Owner ARMY MEDICAL UNIV
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