Bionic bioceramic with through-hole structure and preparation method and application thereof

A technology of bioceramics and through-holes, applied in the field of biomimetic bioceramics with through-hole structure and its preparation, can solve the problems of non-distribution, non-uniform distribution, uncontrollable internal connection, etc., to achieve rapid repair, promote transportation and cell metabolism Effect

Active Publication Date: 2015-05-13
GUANGZHOU HICARE DENTAL EQUIP & MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the porous ceramics prepared by this method have good porosity, the internal material structure is too complex and lacks the penetration inside the material.
At present, some scholars use fascia flaps to wrap the bioceramic to improve its blood supply. However, stem cells can only grow in the periphery and cannot be distributed inside the ceramic body, which greatly affects the repair effect.
[0018] Most of the porous ceramics prepared in the above patents and lite

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0047] Example 1

[0048] The method for preparing a bionic bioceramic with a through-hole structure of this embodiment includes the following operation steps:

[0049] (1) Preparation of the mold: a cylindrical mold body with an inner diameter of 20 mm and a height of 80 mm and its matching top cover and bottom plate are selected. The preparation material of the mold body is zirconia ceramics, and the top cover and bottom plate are prepared by poly Ethylene, the main body of the mold, the top cover and the bottom plate surround the mold cavity. The bottom plate is fixed with a needle-shaped cylindrical metal wire with a diameter of 500 microns and an interval of 1 mm. The metal wire extends to the top cover in the mold cavity;

[0050] (2) Preparation of the plastic porous scaffold: Fill the ABS plastic particles with a diameter of 300μm~400μm from the upper end of the mold body into the mold cavity, put them in an oven and heat at 180°C for 30 minutes, so that the surface of the AB...

Example Embodiment

[0052] Example 2

[0053] The method for preparing a bionic bioceramic with a through-hole structure of this embodiment includes the following operation steps:

[0054] (1) Mold preparation: choose a rectangular parallelepiped mold body with a length of 31.4 mm, a width of 10 mm and a height of 18 mm, and its matching top cover and bottom plate. The preparation material of the mold body is zirconia ceramic, and the preparation of the top cover and bottom plate The material is polypropylene. The main body of the mold, the top cover and the bottom plate enclose the mold cavity. The bottom plate is fixed with needle-shaped cylindrical polyethylene hard wires with a diameter of 300 microns and an interval of 700 microns. The hard wires are in the mold cavity. Extend to the top cover.

[0055] (2) Preparation of the plastic porous scaffold: fill the ABS plastic particles with a diameter of 200μm~300μm into the mold cavity, add acetone to dissolve the surface of the ABS plastic particles ...

Example Embodiment

[0057] Example 3

[0058] The method for preparing a bionic bioceramic with a through-hole structure of this embodiment includes the following operation steps:

[0059] (1) Mold preparation: Choose a cube mold body with a side length of 24 mm and its matching top cover and bottom plate. The preparation material of the mold body is alumina ceramics, and the preparation material of the top cover and bottom plate is polypropylene. The top cover and the bottom plate enclose the mold cavity, and the bottom plate is fixed with an S-shaped cylindrical polypropylene hard wire with a diameter of 500 microns and an interval of 1 mm. The hard wire extends to the top cover in the mold cavity.

[0060] (2) Preparation of the plastic porous scaffold: fill the polycarbonate particles with a diameter of 400μm~500μm into the mold cavity, add acetone to dissolve the surface of the polycarbonate particles and bond each other, rinse off the acetone with distilled water, and then combine The bonded poly...

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Abstract

The invention belongs to the technical field of bionic bioceramics, and discloses a bionic bioceramic with a through-hole structure and a preparation method and application thereof. The method for preparing the bionic bioceramic with the through-hole structure comprises the following steps: firstly, preparing a mold with a through filament, feeding organic plastic granules into the mold to prepare a plastic porous scaffold, loading ceramic powder and a binder into the pores of the plastic porous scaffold, removing the through filament and the plastic porous scaffold, sintering at a certain temperature to obtain the bionic bioceramic with the through-hole structure. According to the invention, the shape, size and density of the through hole of the bionic bioceramic can be controlled well through the shape, size and distribution of the through filament, and the bionic bioceramic with the through-hole structure has an obvious advantage when being used for the repair and replacement of cancellous bone or a scaffold for tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biomimetic bioceramics, and in particular relates to a biomimetic bioceramic with a through-hole structure and a preparation method and application thereof. Background technique [0002] Bone defects caused by fractures, bone diseases and bone cysts have always been one of the difficult problems in the field of orthopedics. Bone repair materials are mainly autologous bone, allogeneic bone and artificial bone, and porous bioactive ceramic artificial bone has become an ideal bone tissue replacement and repair material due to its good biocompatibility and degradability. [0003] For porous bioceramics, there are various preparation methods and applications: [0004] Patent CN 101690828 A discloses a method for preparing a gradient porous bioceramic scaffold. Through the steps of manufacturing a three-dimensional shell, pouring bioceramic slurry, freeze-drying and sintering, a layered structure with relative...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/56A61L27/36A61L27/38C04B38/06C04B35/447C04B35/622
Inventor 张德贵叶建东田科巍陈成洪
Owner GUANGZHOU HICARE DENTAL EQUIP & MATERIAL CO LTD
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