A biomimetic bioceramic with a through-hole structure and its preparation method and application

A bio-ceramic and through-hole technology, which is applied in the field of biomimetic bio-ceramics with through-hole structure and its preparation, can solve the problems of inhomogeneous distribution, inability to distribute, low communication rate, etc. Effect

Active Publication Date: 2016-08-17
GUANGZHOU HICARE DENTAL EQUIP & MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the porous ceramics prepared by this method have good porosity, the internal material structure is too complex and lacks the penetration inside the material.
At present, some scholars use fascia flaps to wrap the bioceramic to improve its blood supply. However, stem cells can only grow in the periphery and cannot be distributed inside the ceramic body, which greatly affects the repair effect.
[0018] Most of the porous ceramics prepared in the above patents and literatures have the problems of uncontrollable internal connection, low communication rate or poor connectivity. Crawling, material degradation, and angiogenesis are of great significance; bioceramics have poor internal permeability, resulting in the enrichment of bone marrow stem cells in the periphery of the material, which cannot be evenly distributed inside, especially for non-load-bearing bone defects, and the congestion of the medullary cavity affects the repair effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A method for preparing a biomimetic bioceramic with a through-hole structure in this embodiment includes the following steps:

[0049] (1) Preparation of the mould: use a cylindrical mold body with an inner diameter of 20 mm and a height of 80 mm and the matching top cover and bottom plate. Ethylene, the mold body, the top cover and the bottom plate form a mold cavity, and the bottom plate is fixed with needle-shaped cylindrical wires with a diameter of 500 microns and an interval of 1 mm, and the metal wires extend to the top cover in the mold cavity;

[0050] (2) Preparation of plastic porous support: Fill ABS plastic particles with a diameter of 300 μm to 400 μm into the mold cavity from the upper opening of the mold body, and heat in an oven at 180°C for 30 minutes to melt the surface of the ABS plastic particles and bond them to each other. , then take out the mutually bonded ABS plastic particles together with the base plate and the wire from the mold cavity, cool...

Embodiment 2

[0053] A method for preparing a biomimetic bioceramic with a through-hole structure in this embodiment includes the following steps:

[0054] (1) Preparation of the mould: the selection length is 31.4 millimeters, the width is 10 millimeters and the height is 18 millimeters cuboid mold main body and its matched top cover and bottom plate, the preparation material of mold main body is zirconia ceramics, the preparation of top cover and bottom plate The material is polypropylene, the mold body, the top cover and the bottom plate form a mold cavity, and the needle-shaped cylindrical polyethylene hard wire with a diameter of 300 microns and a distance of 700 microns is fixed on the bottom plate, and the hard wire is in the mold cavity Extends to the top cover.

[0055] (2) Preparation of plastic porous scaffold: Fill ABS plastic particles with a diameter of 200 μm to 300 μm into the mold cavity, add acetone to dissolve and bond the surfaces of ABS plastic particles, rinse off the ...

Embodiment 3

[0058] A method for preparing a biomimetic bioceramic with a through-hole structure in this embodiment includes the following steps:

[0059] (1) Preparation of the mould: select a cube mold main body with a side length of 24 millimeters and matching top cover and base plate, the preparation material of the mold main body is alumina ceramics, and the preparation material of the top cover and the bottom plate is polypropylene, the mold main body, The top cover and the bottom plate form a mold cavity, and S-shaped cylindrical polypropylene hard wires with a diameter of 500 microns and an interval of 1 mm are fixed on the bottom plate, and the hard wires extend to the top cover in the mold cavity.

[0060] (2) Preparation of plastic porous scaffolds: Fill polycarbonate particles with a diameter of 400 μm to 500 μm into the mold cavity, add acetone to dissolve and bond the surfaces of polycarbonate particles, rinse off the acetone with distilled water, and then place the The bonde...

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Abstract

The invention belongs to the technical field of bionic bioceramics, and discloses a bionic bioceramic with a through-hole structure and a preparation method and application thereof. The method for preparing the bionic bioceramic with the through-hole structure comprises the following steps: firstly, preparing a mold with a through filament, feeding organic plastic granules into the mold to prepare a plastic porous scaffold, loading ceramic powder and a binder into the pores of the plastic porous scaffold, removing the through filament and the plastic porous scaffold, sintering at a certain temperature to obtain the bionic bioceramic with the through-hole structure. According to the invention, the shape, size and density of the through hole of the bionic bioceramic can be controlled well through the shape, size and distribution of the through filament, and the bionic bioceramic with the through-hole structure has an obvious advantage when being used for the repair and replacement of cancellous bone or a scaffold for tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biomimetic bioceramics, and in particular relates to a biomimetic bioceramic with a through-hole structure and a preparation method and application thereof. Background technique [0002] Bone defects caused by fractures, bone diseases and bone cysts have always been one of the difficult problems in the field of orthopedics. Bone repair materials are mainly autologous bone, allogeneic bone and artificial bone, and porous bioactive ceramic artificial bone has become an ideal bone tissue replacement and repair material due to its good biocompatibility and degradability. [0003] For porous bioceramics, there are various preparation methods and applications: [0004] Patent CN 101690828 A discloses a method for preparing a gradient porous bioceramic scaffold. Through the steps of manufacturing a three-dimensional shell, pouring bioceramic slurry, freeze-drying and sintering, a layered structure with relative...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/56A61L27/36A61L27/38C04B38/06C04B35/447C04B35/622
Inventor 张德贵叶建东田科巍陈成洪
Owner GUANGZHOU HICARE DENTAL EQUIP & MATERIAL CO LTD
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