Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefditoren pivoxil tablets

A technology of cefditoren pivoxil and cefditoren, which is applied in the field of medicine, can solve the problems of high water content, long drying time, and limited improvement of drug dissolution rate, and achieve the effect of fast dissolution rate and simple process

Active Publication Date: 2015-06-10
SHANDONG NEWTIME PHARMA
View PDF8 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] CN102846570B discloses a kind of cefditoren pivoxil tablet, adopts the method that water-soluble adjuvant and raw material are pulverized together to improve the wettability of medicine, adopts dry granulation to prepare tablet then with filler, disintegrating agent etc., this method is due to The crystal form of the raw material has not been fundamentally changed, so the dissolution rate of the drug is limited, and the dry granulation process is complicated, the dust production is large, the particle size is uneven, and the surface finish of the pressed tablet is poor
This method has long drying time, high moisture content, and the risk of incomplete acid-base neutralization, which seriously affects the stability of the product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefditoren pivoxil tablets
  • Cefditoren pivoxil tablets
  • Cefditoren pivoxil tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation Process:

[0023] Cefditoren pivoxil was dissolved in diethylene glycol monoethyl ether and 40g ethanol, added hydroxypropyl cellulose, stirred to dissolve, then added the prescribed amount of fumed silica for adsorption, and then mixed with mannitol and cross-linked carboxylate Sodium methylcellulose and magnesium stearate are uniformly mixed and compressed by direct compression technology.

Embodiment 2

[0025]

[0026] Preparation Process:

[0027] Cefditoren pivoxil is dissolved in diethylene glycol monoethyl ether and 40g ethanol, adds hydroxypropyl cellulose, stirs and makes dissolving, then adds the fumed silicon dioxide adsorption of recipe quantity, then with pregelatinized starch, low The hydroxypropyl cellulose and magnesium stearate are mixed evenly and compressed by direct compression technology.

Embodiment 3

[0029]

[0030] Preparation Process:

[0031] Cefditoren pivoxil was dissolved in diethylene glycol monoethyl ether and 40g ethanol, added hydroxypropyl cellulose, stirred to dissolve, then added the prescribed amount of fumed silica for adsorption, and then mixed with mannitol and cross-linked carboxylate Sodium methylcellulose and magnesium stearate are uniformly mixed and compressed by direct compression technology.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines, and in particular relates to cefditoren pivoxil tablets. The cefditoren pivoxil tablets comprise cefditoren pivoxil, hydroxy propyl cellulose and gas phase silicon dioxide. A preparation method comprises the following steps: dissolving cefditoren pivoxil and hydroxy propyl cellulose into diethylene glycol monoethyl ether, adding gas phase silicon dioxide for performing adsorption, then uniformly mixing with pharmaceutically acceptable auxiliary materials, and pressing a mixture by using a direct tabletting process. Compared with the prior art, the cefditoren pivoxil tablets disclosed by the invention are high in medicine dissolution speed and simple in process, do not need to add surfactants, and also do not need micronization treatment.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a cefditoren pivoxil tablet. Background technique [0002] Cefditoren pivoxil (cefditoren pivoxil) is the fourth-generation cephalosporin antibiotic developed by Japan Meiji Seika Co., Ltd. It has broad-spectrum and high-efficiency antibacterial activity, especially for respiratory tract infections with strong drug resistance antibacterial effect. As a prodrug, cefditoren pivoxil itself is inactive, and after oral administration, it is metabolized into cefditoren by esterase in the gastrointestinal tract to exert antibacterial effect. [0003] Chemical name: (-)-(6R,7R)-2,2-dimethylpropionyloxymethyl 7-[(Z)-2-(2-amino-4-thiazolyl)-2-]methoxy Aminoacetamido]-3-[(Z)-2-(4-methyl-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4,2, 0] Oct-2-ene-2-carboxylate. [0004] Chemical Structure: [0005] [0006] Cefditoren pivoxil is a β-lactam antibiotic with an unstable chemical stru...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/546A61K47/38A61K47/04A61P31/04A61P11/00
Inventor 张贵民郭洪涛刘延凤
Owner SHANDONG NEWTIME PHARMA
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com