Method of detecting heavy metal lead, cadmium, arsenic and copper in TCM (Traditional Chinese Medicine) tablet

A technology of traditional Chinese medicine decoction pieces and detection methods, which is applied in the field of analysis and detection, can solve the problems of inapplicability, difficulty in removing organic particles, and low results, and achieve the effects of simple operation, avoiding the loss of heavy metal elements, and fast processing speed

Active Publication Date: 2015-06-10
金木集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the advantages of good recovery, high precision, fast speed, easy operation, safety and no pollution to the environment. However, this method is only suitable for samples with a single composition and no organic matter. The extraction cannot com...

Method used

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  • Method of detecting heavy metal lead, cadmium, arsenic and copper in TCM (Traditional Chinese Medicine) tablet
  • Method of detecting heavy metal lead, cadmium, arsenic and copper in TCM (Traditional Chinese Medicine) tablet
  • Method of detecting heavy metal lead, cadmium, arsenic and copper in TCM (Traditional Chinese Medicine) tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 The impact of the type of alkali used in step one and its concentration on the determination of heavy metal content

[0056] The Chinese herbal decoction pieces used in this example are Scutellaria baicalensis.

[0057] The sample pretreatment method is as follows:

[0058] Step 1. Alkaline hydrolysis: take 5g of Chinese herbal medicine powder, add 10mL of dilute alkali solution containing 10% ammonium chloride by mass fraction, shake, and then undergo 800W microwave treatment for 30s to obtain an alkaline hydrolysis sample solution;

[0059] Step 2, acid extraction: quickly add 20mL of dilute acid solution containing 5% hydrogen peroxide (the dilute acid solution is 0.5mol / L hydrochloric acid solution, prepared before use) to the obtained product in step 1 under stirring conditions In the alkaline hydrolysis sample solution, detect the pH of the solution, if the pH value is greater than 2, use the dilute acid solution (hydrogen peroxide-free) to adjust the p...

Embodiment 2

[0091] Example 2 Influence of microwave treatment power and treatment time on the determination of heavy metal content in step one

[0092] The Chinese herbal decoction pieces used in this example are Scutellaria baicalensis.

[0093] The sample pretreatment method is as follows:

[0094] Step 1. Alkaline hydrolysis: take 5 g of Chinese herbal decoction pieces powder, add 10 mL of 0.5 mol / L sodium hydroxide solution containing 10% ammonium chloride by mass fraction, shake and process with microwaves to obtain an alkaline hydrolysis sample solution;

[0095] Step 2 to step 5 are the same as in Example 1.

[0096] Quantitative determination method is the same as embodiment 1.

[0097] Measurement results and analysis

[0098] (1) When the microwave processing power is 500, 800, 1000, 1200, 1500W, and the processing time is 30s, the measured contents of heavy metals lead, cadmium, arsenic, and copper in the decoction pieces of traditional Chinese medicine are shown in Table 3,...

Embodiment 3

[0106] The impact of the type and concentration of the acid used in the step 2 on the determination of heavy metal content in embodiment 3

[0107] The Chinese herbal decoction pieces used in this example are Scutellaria baicalensis.

[0108] The sample pretreatment method is as follows:

[0109] Step 1. Alkaline hydrolysis: Take 5 g of Chinese herbal decoction pieces powder, add 10 mL of 0.5 mol / L sodium hydroxide solution containing 10% ammonium chloride by mass fraction, shake, and treat with 800W microwave for 30 seconds to obtain an alkaline hydrolysis sample solution;

[0110] Step 2, acid extraction: 20mL of dilute acid solution (prepared before use) containing 5% hydrogen peroxide by mass fraction is quickly added to the alkali hydrolysis sample solution obtained in step 1 under stirring conditions, and the pH and pH value of the solution are detected If it is greater than 2, use the dilute acid solution (without hydrogen peroxide) to adjust the pH value to less than ...

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Abstract

The invention discloses a method of detecting heavy metal lead, cadmium, arsenic and copper in a TCM (Traditional Chinese Medicine) tablet. The method comprises the following steps: after carrying out microwave alkaline hydrolysis on tablet powder with an ammonia chloride containing diluted alkali solution, quickly adding hydrogen peroxide containing dilute acid solution, and ultrasonically extracting after the pH value is adjusted to be not more than 2; carrying out constant volume on an extract after the centrifugation, condensation and microfiltration; and finally, determining by adopting an atomic absorbency method. According to the method, a sample is preprocessed by an alkaline-hydrolysis acid-extracting method, therefore, the loss of heavy metal element caused by high temperature of a dry ashing method and air pollution and potential danger caused by a resolution method can be prevented; meanwhile, the method has the advantages of being good in recovery rate, high in precision, fast in processing speed, convenient to operate, wide in range of application and the like, and is more suitable for the quantitative determination of trace metal elements.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and in particular relates to a method for detecting heavy metals lead, cadmium, arsenic and copper in decoction pieces of traditional Chinese medicine. Background technique [0002] Chinese medicine is the traditional medicine of our country and the treasure of the Chinese nation. The quality of its decoction pieces directly affects the effect of traditional Chinese medicine treatment. During the complex process of traditional Chinese medicine from field production, harvesting, transportation, warehousing, processing, processing, and finally to finished decoction pieces for people to buy and take in pharmacies, there are many factors that will affect the heavy metal content in it, such as planting soil, Applied pesticides and fertilizers, processed utensils, etc. In order to ensure drug safety, my country's "Green Industry Standards for the Import and Export of Medicinal Plants a...

Claims

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Application Information

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IPC IPC(8): G01N21/71G01N21/72G01N21/74
Inventor 钮金木钮立强钮立卫
Owner 金木集团有限公司
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