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A kind of hydrophilic silicone rubber medical dressing and preparation method thereof

A silicone rubber and hydrophilic technology, applied in the field of biomedical materials, can solve the problems of low value-added product growth ability, discontinuous chitosan functional surface, and limited product growth ability, so as to speed up wound healing without sensitization Biocompatibility, the effect of good biocompatibility

Active Publication Date: 2017-03-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the body material of this patent uses medical cotton fiber, which includes the limitations of traditional medical dressings with low added value and limited product growth capacity; and medical cotton fiber and chitosan fiber are interwoven to form the body, and the functional surface of chitosan is discontinuous. Risk of uncoated cotton fibers sticking to newly formed granulation tissue, increasing patient distress
[0006] In the domestic market, traditional medical dressings limited to wound protection are still dominant, and their finished products have low benefits, low added value, small profit margins, and products Limited ability to grow

Method used

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  • A kind of hydrophilic silicone rubber medical dressing and preparation method thereof
  • A kind of hydrophilic silicone rubber medical dressing and preparation method thereof
  • A kind of hydrophilic silicone rubber medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Step (1) First place the methyl vinyl silicone rubber with a side length of 15mm×10mm in a 172nm ultraviolet irradiation reactor and irradiate it for 200s to obtain a surface-activated silicone rubber, which will be used immediately later.

[0045] Step (2) Prepare 0.2wt% KH-550 alcohol aqueous solution, the mass ratio of ethanol to water is 95:5, immediately immerse the activated silicone rubber after ultraviolet irradiation in the KH-550 solution, reflux for 5 hours, take it out, Ethanol rinse, N 2 Purge, put in an oven at 100°C to react for 5 minutes, and obtain a silicone rubber sample with KH-550 grafted on the surface, which will be used immediately later.

[0046] Step (3) Put the silicone rubber sample grafted with KH-550 on the surface into the acetone solution of 1wt% hexamethylene diisocyanate (HDI), react at 50°C for 0.5h, take it out, wash it with acetone, N 2 Purge, then add to 0.5wt% chitosan solution, react at 70°C for 10min, take it out, rinse with wea...

Embodiment 2

[0052] Step (1) First place the methyl vinyl silicone rubber with a side length of 15mm×10mm in a 172nm ultraviolet irradiation reactor and irradiate it for 200s to obtain a surface-activated silicone rubber sample, which will be used immediately later.

[0053] Step (2) Prepare a 0.5wt% IPTS solution, adjust the pH to 5, immediately immerse the activated silicone rubber after UV irradiation in the IPTS solution, reflux for 3 hours, take it out, rinse with ethanol, and N 2 Purge to obtain a silicone rubber sample with IPTS grafted on the surface, which will be used immediately later.

[0054] Step (3) Add the silicone rubber sample grafted with IPTS on the surface to 1wt% O-2’-hydroxypropyltrimethylammonium chloride chitosan solution, react at 70°C for 10min, take it out, rinse with deionized water, and N 2 Purging to obtain a silicone rubber film grafted with quaternized chitosan on the surface.

[0055] Figure 4 It is the Fourier transform infrared spectrum (FT-IR) map of...

Embodiment 3

[0058] Step (1) First place the methyl vinyl silicone rubber with a side length of 15mm×10mm in a 172nm ultraviolet irradiation reactor and irradiate it for 200s to obtain a surface-activated silicone rubber sample, which will be used immediately later.

[0059] Step (2) Prepare 1wt% KH-560 alcohol aqueous solution, adjust pH = 5, the mass ratio of methanol to water is 95:5, immediately immerse the activated silicone rubber after ultraviolet irradiation in the KH-550 solution, and reflux reaction 5h, take it out, rinse with methanol, N 2 Purge, put in an oven at 100°C to react for 5 minutes, and obtain a silicone rubber sample with KH-560 grafted on the surface, which will be used immediately later.

[0060] Step (3) Put the silicone rubber sample grafted with KH-560 on the surface into a 1wt% chitosan solution, react at 70°C for 10 minutes, take it out, rinse with weakly acidic deionized water, N 2 Purging to obtain a silicone rubber film grafted with chitosan on the surface...

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Abstract

The invention relates to hydrophilic silicone rubber wound dressing and a preparation method thereof. The hydrophilic silicone rubber wound dressing is composed of a matrix and a surface graft, wherein the matrix is made of a silicone rubber material; the surface graft is composed of hydrophilic substance; the silicone rubber material comprises room temperature vulcanized silicone rubber or heat curing silicone rubber; the hydrophilic substance comprises a cellulose derivative, chitosan and a derivative thereof, chondroitin sulfate materials, polyamino acid, synthetic peptide or collagen. The prepared silicon rubber film has good surface water wettability and good biocompatibility.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a hydrophilic silicone rubber medical dressing and a preparation method thereof. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. The domestic market for medical dressings is huge. Every year, tens of millions of people in China have skin trauma caused by accidents or operations, and chronic skin injuries caused by pressure sores, diabetes, varicose veins and other diseases caused by the aging population. The use of up to billions of RMB. In recent years, the comprehensive advancement of my country's medical reform and the large demand for products have made my country's medical dressing market grow rapidly at a compound annual growth rate of more than 30%. However, at present, more than...

Claims

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Application Information

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IPC IPC(8): A61L15/30A61L15/42A61L15/28A61L15/26A61L15/32C08J7/12C08L83/04
Inventor 吴叔青覃锋李建雄
Owner SOUTH CHINA UNIV OF TECH