Preparation method of hemostatic material

A technology of hemostatic material and thrombin, which is applied in the fields of biochemical fiber treatment, medical science, absorbent pad, etc., can solve the problems of wasting rescue hemostasis time and complicated use of hemostatic materials, and achieves the goal of saving rescue time, simplifying operation and convenient operation. Effect

Active Publication Date: 2015-06-24
GUANGZHOU DIANFANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The hemostatic material prepared by the existing preparation technology is more complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0042] Weigh 300 mg chitosan, dissolve in 2.25 ml trifluoroethanol solution, stir magnetically for 30 minutes, add 0.25 ml pH6.8 phosphate buffer and stir for 10 minutes to obtain 12% chitosan solution;

[0043] The chitosan solution was subjected to high-voltage electrospinning, the setting voltage was 30kV, the spinning rate was 2.0 ml / h, and a chitosan electrospinning membrane with an area of ​​about 70 cm2 was obtained after 1.3 hours;

[0044] The material was vacuum-dried at room temperature for 1 hour, sealed with a light-proof and moisture-proof bag, sterilized by radiation, and stored at room temperature.

Embodiment 3

[0046] Weigh 90 mg of oxidized cellulose, dissolve it in 2.7 ml of tetrahydrofuran solution, stir magnetically for 30 minutes, add 0.3 ml of 10× MEM medium and stir for 10 minutes to obtain a 3% oxidized cellulose solution;

[0047] The oxidized cellulose solution was subjected to high-voltage electrospinning, the voltage was set at 10kV, the spinning rate was 0.5 ml / h, and an electrospun oxidized cellulose membrane with an area of ​​about 70 cm2 was obtained after 6 hours;

[0048] The material was vacuum-dried at room temperature for 1 hour, sealed with a light-proof and moisture-proof bag, sterilized by radiation, and stored in a cool and dry place.

Embodiment 4

[0050] Weigh 750 mg of polylactic acid, dissolve in 2.7 ml of dimethylformamide solution, stir magnetically for 30 minutes, add 0.3ml of normal saline and stir for 10 minutes to obtain a 25% polylactic acid solution;

[0051] The polylactic acid solution was subjected to high-voltage electrospinning, the voltage was set at 30 kV, the spinning rate was 1.8 ml / h, and an electrospun polylactic acid material with an area of ​​about 70 cm2 was obtained after 1.7 hours;

[0052]The material was vacuum-dried at room temperature for 1 h, sealed with a light-proof and moisture-proof bag, sterilized by radiation, and stored at 4°C.

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PUM

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Abstract

The invention discloses a preparation method for a hemostatic material, an absorbable carrier material prepared by an electrospinning technology or a combination of the absorbable carrier material and a blood coagulation factor film-shaped material prepared by the electrospinning technology, wherein blood coagulation factors are fibrinogen and thrombin from human or animal blood. The superfine fibre prepared by the electrospinning technology has the advantages that the specific surface area of the reticulate structure of the hemostatic material is increased, and the mutual fusion action between the reticulate structure and tissues is promoted. The hemostatic material is good in biocompatibility, more remarkable in hemostatic effect and convenient to use, and can be used for hemostasis in trauma treatment and clinical operations.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to a preparation method of a hemostatic material. Background technique [0002] Rapid and thorough hemostasis during surgery, reducing the amount of bleeding, and keeping the operative field clear are one of the cores of basic surgical operations. In all kinds of first aid, such as frequent traffic and accidents, it is also generally faced with problems such as rapid and effective hemostasis, relief of patients' pain, and saving people's lives. According to relevant national regulations, hemostatic materials from different sources can be divided into hemostatic drugs and hemostatic medical devices. Currently, commonly used local hemostatic materials include fibrin glue, thrombin powder, gelatin sponge, collagen sponge, chitosan sponge, oxidized cellulose, microfibrillar collagen, alginate fiber, zeolite, cyanoacrylate, plant polysaccharide powder Wait. Local hemostatic materials...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/44A61L15/32D06M16/00
Inventor 张俊辉李若冰万德夫付岩霖朱晋辉李敏万华印
Owner GUANGZHOU DIANFANG BIOTECH CO LTD
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