A kind of method adopting chitosan and β-cyclodextrin to prepare hydrophobic drug magnetic targeting sustained and controlled release carrier
A technology of controlled release carrier and cyclodextrin, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems affecting the clinical therapeutic value of drugs, low bioavailability and short half-life. and other problems, to achieve the effect of excellent loading and slow release
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Embodiment 1
[0024] Implementation Example 1: Preparation of Chitosan / Cyclodextrin-modified Magnetic Microspheres
[0025] (1) Accurately weigh 3.98 g FeCl 2 4H 2 O and 10.82 g FeCl 3 ·6H 2 O, dissolved in 95 mL pure water, in N 2 Under the protection of , the temperature of the above solution was raised to 60°C, and under vigorous stirring (1200rpm), 56 mL of 25% ammonia solution was added, and the system quickly turned black. Then the temperature of the system was raised to 90°C, 1.5 g of trisodium citrate was added, and after stirring for 30 min, the obtained product was washed three times with deionized water and absolute ethanol in turn, and the supernatant was removed with the assistance of an external magnetic field. the above Fe 3 o 4 Nanoparticles, dispersed in the mixed solution of ethanol and water (the volume ratio of ethanol and water is 4:1), and made into a suspension with a concentration of 50 mg / mL, take 100 mL of the above suspension, and then add 10 mL of 25% Ammo...
Embodiment 2
[0029] Implementation example 2: preparation of magnetic microspheres modified by chitosan / cyclodextrin
[0030] (1) Accurately weigh 3.98 g FeCl 2 4H 2 O and 6.76 g FeCl 3 ·6H 2 O, dissolved in 95 mL pure water, in N 2 Under the protection of , the temperature of the above solution was raised to 60°C, and under vigorous stirring (1200 rpm), 56 mL of ammonia solution with a mass fraction of 10% was added, and the system quickly turned black. Then the temperature of the system was raised to 70°C, 0.5 g of trisodium citrate was added, and after stirring for 30 min, the obtained product was washed three times with deionized water and absolute ethanol successively, and the supernatant liquid was removed with the assistance of an external magnetic field. the above Fe 3 o 4 Nanoparticles, dispersed in a mixed solution of ethanol and water (volume ratio of ethanol and water: 4:1), made into a suspension with a concentration of 10 mg / mL, took 100 mL of the above suspension, and ...
Embodiment 3
[0034] Implementation example 3: the cyclodextrin immobilization capacity determination of the magnetic microspheres modified by chitosan / cyclodextrin
[0035] Accurately weigh 0.1 g of glucose standard substance dried to constant weight, add an appropriate amount of water to dissolve, transfer to a 100 mL volumetric flask, add distilled water to the mark and shake well to prepare a glucose solution with a concentration of 1 mg / mL, and then accurately pipette 10 mL, dilute to 100 mL with distilled water to obtain 0.1 mg / mL glucose standard solution. Pipette 0.05, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0 mL of the stock solution and dilute to 2 mL with water, add 1 mL of 5% phenol reagent, and mix well. Add 5 mL of concentrated sulfuric acid along the tube wall, let it stand for 5 min, shake it, heat it in a boiling water bath for 15 min, and immediately transfer it to a cold water bath to cool to room temperature. Using distilled water as a blank, the absorbance was measured at a wavelen...
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