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Preparation method and application of kaempferol imprinted microsphere based on nanometer titanium dioxide

A technology of kaempferol and microspheres, which is applied in chemical instruments and methods, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve the problems of low separation and treatment efficiency and serious embedding of polymer microspheres, and achieve Effects of improving adsorption performance, regular particle shape, and increasing specific surface area

Inactive Publication Date: 2015-07-29
BEIJING FORESTRY UNIVERSITY
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Problems solved by technology

[0005] The present invention provides a method of preparing TiO by seed precipitation polymerization 2 The method of molecularly imprinting polymer microspheres on the surface of kaempferol as the core solves the problems of serious embedding of polymer microspheres prepared by precipitation polymerization and low efficiency of separation and treatment. The prepared imprinted polymers can be used Selective extraction, separation and enrichment of flavonoid aglycon substances in the crude extract

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  • Preparation method and application of kaempferol imprinted microsphere based on nanometer titanium dioxide
  • Preparation method and application of kaempferol imprinted microsphere based on nanometer titanium dioxide
  • Preparation method and application of kaempferol imprinted microsphere based on nanometer titanium dioxide

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Embodiment 1

[0021] Dissolve 1mmol template molecule kaempferol and 4mmol functional monomer 4-VP into 40ml porogen acetonitrile, ultrasonically disperse for 10min, then add 20mg TiO 2 , stirred mechanically for 2 hours, passed nitrogen for 20 minutes to deoxidize, then added 20 mmol of cross-linking agent EDMA, passed nitrogen for 20 minutes to deoxidize, added 50 mg of initiator AIBN, sealed in a vacuum state, and reacted in an oil bath at 63°C for 24 hours to obtain a solid polymer. Pass the synthesized imprinted polymer through a 200-mesh sieve, use methanol:acetic acid (V / V, 9:1) as the extraction solution, extract the polymer particles for 72 hours, and then use pure methanol for Soxhlet extraction for 24 hours, equilibrate Remove acetic acid. The obtained polymer was dried in a vacuum drying oven at 60° C. for 24 hours to obtain a molecularly imprinted polymer on the surface of kaempferol. Prepared without TiO 2 The kaempferol molecularly imprinted polymer was used as a blank comp...

Embodiment 2

[0026] Dissolve 1mmol template molecule kaempferol and 6mmol functional monomer AM into 30ml porogen acetonitrile, ultrasonically disperse for 10min, then add 30mg TiO 2, stirred mechanically for 2 hours, passed nitrogen for 20 minutes to deoxidize, then added 30 mmol of cross-linking agent EDMA, passed nitrogen for 20 minutes to deoxidize, added initiator AIBN 100 mg, sealed in a vacuum state, and reacted in an oil bath at 63°C for 24 hours to obtain a solid polymer. Pass the synthesized imprinted polymer through a 200-mesh sieve, use methanol:acetic acid (V / V, 9:1) as the extraction solution, extract the polymer particles for 72 hours, and then use pure methanol for Soxhlet extraction for 24 hours, equilibrate Remove acetic acid. The obtained polymer was dried in a vacuum drying oven at 60° C. for 24 hours to obtain a molecularly imprinted polymer on the surface of kaempferol.

[0027] (1) Adsorption kinetics experiment

[0028] Weigh 50mg of the eluted surface molecularly...

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Abstract

The invention provides a preparation method of a kaempferol surface molecularly imprinted polymer microsphere with TiO2 as a core by adopting a seed precipitation polymerization technology. The method solves the problems of severe embedding phenomenon and low separating treatment efficiency of polymer microspheres prepared through a precipitation polymerization technology and the problem of easy gelatinization of an initiator in a polymerization solution in the preparation process of imprinted microspheres prepared through a surface imprinting technology needing a surface grafting technology. An imprinted polymer microsphere prepared through adopting the method has the advantages of regular particle shape, uniform size, no agglomeration phenomenon and increased specific surface area, and makes binding sites of a polymer distributed on the surface of the microsphere in order to improve the adsorption performance of the kaempferol surface molecularly imprinted polymer microsphere. The above polymer prepared in the invention can realize effective separation and extraction of ginkgo flavone aglycone, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of surface molecular imprinting, specifically TiO 2 The preparation of molecularly imprinted polymer microspheres on the surface of kaempferol as the core is the preparation of a separation material with high selective recognition performance for kaempferol, and its application in the separation and purification of pharmaceutical components. Background technique [0002] Kaempferol is a flavonoid compound, which has medicinal value such as lowering blood pressure, lowering blood fat, anti-cancer, and enhancing capillary resistance. It is an important active ingredient in Chinese herbal medicine. At present, the traditional methods for extracting flavonoids mainly include solvent method, microwave extraction method, macroporous resin extraction method, supercritical extraction method, capillary electrophoresis method and enzymatic method, etc., but the types of flavonoids are diverse and have similar structur...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F220/20C08F226/06C08F220/56C08F220/06C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 贠延滨张志苗纪静雯张品高严
Owner BEIJING FORESTRY UNIVERSITY
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