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Soft hydrosol auxiliary agent used for ophthalmology

A flexible, hydrosol technology, applied in the direction of active ingredients of alkaline/alkaline earth metal chlorides, sensory diseases, drug combinations, etc., can solve the problem of reducing the interface energy between the complex and the body fluid, increasing the surface electron density, and decreasing the product stability, etc. problem, to reduce the risk of nucleation deposition, slow down the lens opacity, and ensure the effect of performance

Active Publication Date: 2015-08-05
杭州光柱电子科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, these flexible hydrosol adjuvants for intraocular lens implantation generally have the following deficiencies: 1) Due to the large number of polar functional groups contained in them, the surface electron density is increased and the interface energy between the complex and the body fluid is reduced at the same time
2) The presence of a large number of phosphate radicals will induce the supersaturated deposition of calcium phosphate, which will directly lead to a decrease in product stability and eventually lead to lens turbidity
[0007] However, when this technology is used in clinical observation, whether it is used in intraocular lens implantation surgery or as ordinary eye drops, some users report itchy eyes, excessive tears, and even some redness and swelling and other similar allergies. The problem

Method used

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  • Soft hydrosol auxiliary agent used for ophthalmology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 40 g of sodium chloride and dissolve it in 1 liter of sterile double distilled water to make saline.

[0018] Under sterile conditions, mix 3 grams of disodium hydrogen citrate, 12 grams of monosodium hydrogen citrate, 70 grams of hydroxypropyl methylcellulose, 8 grams of sodium chondroitin sulfate, 10 grams of potassium chloride, 6 grams of magnesium chloride, Dissolve 10 grams of sodium acetate in 600 ml of saline, stir slowly at a constant speed for 5 minutes, then adjust the pH to 7.1 with hydrochloric acid or sodium hydroxide solution, and add sterile double distilled water to adjust to 1 liter.

[0019] Appearance of this product: completely transparent, specific gravity: 1.01.

Embodiment 2

[0021] Take 30 g of sodium chloride and dissolve it in 1 liter of sterile double distilled water to make saline.

[0022] Under sterile conditions, mix 3 grams of disodium hydrogen citrate, 12 grams of monosodium hydrogen citrate, 50 grams of hydroxypropyl methylcellulose, 15 grams of sodium hyaluronate, 8 grams of sodium chondroitin sulfate, 15 grams of chlorine Potassium chloride, 6 grams of magnesium chloride, and 15 grams of sodium acetate were dissolved in 600 milliliters of brine, stirred slowly at a constant speed for 5 minutes, and then the pH was adjusted to 7.1 with hydrochloric acid or sodium hydroxide solution, and then adjusted to 1 liter with sterile double-distilled water. have to.

[0023] Appearance of this product: completely transparent, specific gravity 1.02.

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Abstract

The invention relates to medical preparations, and particularly relates to a soft hydrosol auxiliary agent used for ophthalmology, which comprises following components: 0.2-0.5% of disodium hydrogen citrate, 1-1.5% of monosodium hydrogen citrate, 5-8% of hydroxypropyl methylcellulose, 0.5-1% of sodium chondroitin sulfate, 0.5-2% of potassium chloride, 0.3-0.8% of magnesium chloride, 0.3-1.5% of sodium acetate, 1.3-2.5% of sodium chloride, and 85-90% of sterilized double-distilled water and also may comprises 1-3% of sodium hyaluronate. The auxiliary agent, on the premise of ensuring performance, reducing the risk of nucleation and deposition and alleviating lens opacity, is significantly reduced in use amounts of the disodium hydrogen citrate and the magnesium chloride, thereby reducing stimulation on eyes of patients and avoiding complications of itch, weeping and red swelling in eyes. In addition, the preparation is increased in bionic level. The preparation is significantly increased in stability, is suitable for long-time use for nourishing eyes, has the effects of preventing dry eyes and resisting fatigue and has excellent effects.

Description

technical field [0001] The invention relates to medical preparations, in particular to a flexible hydrosol adjuvant used in ophthalmic surgery and treatment. Background technique [0002] Cataract is a common eye disease that can cause clouding of the lens in mild cases and lead to blindness in severe cases. According to the 2010 annual report of the World Health Organization, about 48% of the 18,000,000 blind patients in the world are caused by cataracts caused by aging. At present, China has the largest blind population in the world, about 6,600,000 people, and about 50% of them are caused by cataracts. As my country's population ages, this number will increase significantly. [0003] The mode of treating cataract in the prior art is surgical implantation of intraocular lens. The selection and use of flexible hydrosol adjuvants in surgery is very important, because in the process of injecting the intraocular lens into the anterior chamber of the eyeball through the Scle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61P27/02
Inventor 张效实肖娟
Owner 杭州光柱电子科技有限公司
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