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Antibacterial Modification Method of Silicone Rubber

An antibacterial, silicone rubber technology, applied in the field of antibacterial modification of medical silicone rubber, can solve the problems of unstable surface groups, complicated control and steps, complicated steps, etc., and achieves improved biocompatibility and operation. The effect of easy control of conditions and good antibacterial properties

Active Publication Date: 2018-03-02
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The graft copolymerization method activates the surface of the polymer through a chemical reaction, and then introduces a specific group. The surface group formed is unstable and the steps are cumbersome; the biomimetic coating can be sprayed, sputtered and Such methods cover a layer of biologically active substances on it, but there are also problems such as difficult control of conditions and cumbersome steps.
At present, there is still a lack of an effective method for modifying the antibacterial properties of silicone rubber with easy-to-control operating conditions and simple operating steps.

Method used

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  • Antibacterial Modification Method of Silicone Rubber
  • Antibacterial Modification Method of Silicone Rubber
  • Antibacterial Modification Method of Silicone Rubber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The antibacterial modification of embodiment 1 silicone rubber

[0032] Taking medical silicone rubber as the material to be treated, four groups of medical silicone rubber were selected and marked as Ag1-SR, Ag2-SR, Ag3-SR and SR; The SR, Ag2-SR and Ag3-SR groups were treated with ion dose of 5×10 15 ions / cm 2 , 20×10 15 ions / cm 2 and 50×10 15 ions / cm 2 Perform ion implantation, the ion energy of the Ag ion is 10keV, and the parameter beam current density is set during the ion implantation process is not greater than 1mA / cm 2 , the residual air pressure is not greater than 1×10 -4 Pa, after processing, three groups of antibacterial silicone rubbers are obtained.

Embodiment 2

[0033] Embodiment 2 antibacterial silicone rubber scanning electron microscope detection result

[0034] Ag1-SR, Ag2-SR and Ag3-SR group antimicrobial silicone rubber and SR control group silicone rubber prepared by embodiment 1 are observed and analyzed under scanning electron microscope respectively, and the results are as follows: figure 1 shown by figure 1 It can be seen that under the magnification of 10000 times, there is no difference between the antibacterial silicone rubber Ag ion implantation of the Ag1-SR, Ag2-SR and Ag3-SR groups and the control group silicone rubber SR, indicating that the impact of the Ag ion implantation on the surface structure of the material Change is on a more microscopic scale.

Embodiment 3

[0035] Embodiment 3 antibacterial silicone rubber atomic force microscope detection result

[0036] Ag1-SR, Ag2-SR and Ag3-SR group antimicrobial silicone rubber and SR control group silicone rubber prepared by embodiment 1 are carried out atomic force microscope detection and analysis respectively, the result is as follows figure 2 shown by figure 2 It can be seen that the atomic force microscope is used to analyze and observe from the atomic level that the Ag1-SR, Ag2-SR and Ag3-SR groups have differences in the antibacterial silicone rubber Ag ion implantation and the control silicone rubber SR, and the surface roughness of the silicone rubber after ion implantation The increase indicates that after Ag ion implantation, the change of the surface structure of the material belongs to the atomic level.

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Abstract

The invention belongs to the field of modification of medical materials, and in particular relates to an antibacterial modification method of medical silicone rubber. The antibacterial modification method of silicone rubber is to inject Ag ions into silicone rubber by ion implantation to obtain antibacterial silicone rubber. The ion energy of the Ag ions is 10keV; the ion implantation control condition is beam current density It is not more than 1mA / cm2, and the residual pressure is not more than 1×10‑4Pa; the operating conditions of this method are easy to control, and the operation steps are simple, which overcomes the existing problems of plasma treatment, graft copolymerization, bionic coating, etc. in the existing surface modification technology. Defects such as peeling, stable phase difference, and cumbersome operation process; and this method can control the temperature of the silicone rubber substrate without affecting the properties of the silicone rubber material body, and the hydrophilicity and hydrophobicity of the obtained silicone rubber also have a clear trend of change, all towards hydrophilicity Cell experiments confirmed that the biocompatibility of silicone rubber injected with silver ions is also significantly improved compared with ordinary silicone rubber.

Description

technical field [0001] The invention belongs to the field of modification of medical materials, and in particular relates to an antibacterial modification method of medical silicone rubber. Background technique [0002] Because of its good physical and chemical stability and physiological inertness, such as hydrophobicity, gas permeability, heat resistance, oxidation resistance and aging resistance, silicone rubber can be implanted in the body for a long time, can withstand tissue fluid corrosion, and will not be metabolized, absorbed and damaged by the body. Degradation, and is widely used in the medical field. At present, silicone rubber materials are widely used in the production of prostheses and tooth soft lining materials, such as occluders, maxillofacial prostheses, tooth soft linings, etc. Silicon rubber can also be used as catheters, etc. [0003] As a biological material, especially as an implant material in the body, silicone rubber needs to be in contact with th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/00C08L83/04
Inventor 张一鸣周鑫樊东力王韶亮毛彤春石小花
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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