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A kind of medicine patch and preparation method thereof

A drug and patch technology, applied in the field of medicine, can solve the problems of loss and efficacy ingredient failure, and achieve the effect of reducing the degree of volatilization and lowering the heating temperature

Inactive Publication Date: 2018-05-18
崔建平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Another object of the present invention is to provide a preparation method of a drug patch, which can complete the preparation of the patch at a low temperature, and solve the problem of the failure or loss of the effective components of the drug, especially the traditional Chinese medicine, which needs to be heated during the preparation of the patch.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1) Take styrene-isoprene-styrene block copolymer and ethyl acetate at a mass ratio of 1:1, soak the styrene-isoprene-styrene block copolymer in ethyl acetate at 30°C 12h in the ester, stir evenly, obtain this synthetic rubber colloid, set aside;

[0047] 2) Take 50 parts of synthetic rubber colloid prepared in step 1), 5 parts of liquid paraffin, 5 parts of hydrogenated rosin, and 30 parts of Rhizoma Chuanxiong extract, and stir evenly at 40°C to obtain a drug adhesive layer;

[0048] 3) Prepare the non-woven fabric for the backing layer, the drug adhesive layer prepared in step 2) and the release paper for the protective layer into a drug patch in a coating machine.

Embodiment 2

[0050] Preparation of compound salvia miltiorrhiza medicinal composition:

[0051] 1) taking by weight the raw materials of traditional Chinese medicine: 75.17% Danshen, 23.5% Radix Notoginseng and 1.33% Borneol;

[0052] 2) Take the pulverized Danshen and Panax notoginseng coarse powder, add water with 6 times the mass of Salvia miltiorrhiza and Panax notoginseng, boil for 1.5 hours, filter to obtain the filtrate, and add 6 times the mass of medicinal residues to an ethanol aqueous solution with a volume concentration of 75%. , stirred, and left to stand for 18 hours, take the supernatant and mix it with the filtrate, recover ethanol, concentrate it into a liquid extract with a relative density of 1.2 at 25°C, and set aside;

[0053] 3) Pulverizing the borneol and adding it to the liquid extract obtained in step (2) to obtain a pharmaceutical composition.

[0054] Patch preparation:

[0055] 1) Take polyisobutene and n-hexane according to a mass ratio of 1:2, soak polyisobu...

Embodiment 3

[0059] The compound salvia miltiorrhiza composition was prepared according to the method in Example 2.

[0060] 1) Take styrene-butadiene-styrene block copolymer and butyl acetate at a mass ratio of 1:3, soak the styrene-butadiene-styrene block copolymer in butyl acetate at 25°C 16h, stir evenly, obtain this synthetic rubber colloid, for subsequent use;

[0061] 2) Take 65 parts of synthetic rubber colloid prepared in step 1), 15 parts of naphthenic oil, 7.5 parts of tackifier (the tackifier is C9 petroleum resin and terpene resin with a mass ratio of 1:1), compound Danshen drug 20 parts of the composition were heated and mixed at 60°C to obtain a drug adhesive layer;

[0062] 3) The backing layer paper, the drug adhesive layer prepared in step 2) and the protective layer PET film are prepared into a drug patch in a coating machine.

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Abstract

The invention discloses a medical patch and a preparation method thereof. The medical patch comprises a backing layer and a medical adhesive layer. A preparation method of the medical adhesive layer comprises 1, immersing synthetic rubber in an organic solvent according to a mass ratio of 1: 1-5 to obtain synthetic rubber colloid and 2, stirring the synthetic rubber colloid and drugs at a temperature of 40-80 DEG C to obtain a uniform mixture. The preparation method has simple processes, prevents drug volatilization or failure caused by over-high temperature, effectively retains effective components of the drugs, improves medical effects and is suitable for the medical patch containing traditional Chinese medicine extract products and / or volatile components.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicinal patch and a preparation method thereof. Background technique [0002] Transdermal patch is the third-generation drug dosage form after oral and injection. In the 1980s, it emerged with the successful listing of the scopolamine patch (Transderm-Scop) of Alza Company in the United States. Drug system", that is, drugs are absorbed through the skin and exert systemic or local effects. The plaster in my country can be regarded as a patch of the modern new dosage form "transdermal drug delivery preparation". After the Second World War, the rapid development of synthetic rubber, synthetic resin, etc., and the advent of new polymer materials such as polypropylene, etc., provided a basis for the technological progress and development of patches. [0003] The preparation method of the existing patch is usually to firstly prepare the hot melt adhesive, and then mix and heat the hot mel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/32A61K36/537A61P29/00A61P9/10A61P9/00A61P3/10A61P35/00A61K31/045
Inventor 崔建平
Owner 崔建平
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