Application of nanofiber membrane in preparation of rotator cuff injury treatment material

A nanofiber membrane, rotator cuff injury technology, applied in the fields of fiber chemical characteristics, rayon manufacturing, medical science, etc., can solve the problems of the safety of viral vectors, restricting effects, etc., and achieve good biocompatibility and biodegradation. Sex, promotes healing, accelerates remodeling

Inactive Publication Date: 2015-08-19
赵金忠 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although these methods can also play a certain role, because the growth factor can only maintain activity for a short period of time, thus l...

Method used

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  • Application of nanofiber membrane in preparation of rotator cuff injury treatment material
  • Application of nanofiber membrane in preparation of rotator cuff injury treatment material
  • Application of nanofiber membrane in preparation of rotator cuff injury treatment material

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Embodiment Construction

[0033] The present invention will be further described below with reference to the accompanying drawings and specific embodiments to better understand the present invention.

[0034] 1. Preparation of Nanofibrous Membranes

[0035] a) Materials

[0036] Polylactic acid-glycolic acid is prepared by the ring-opening polymerization of lactide and glycolide, using tin chloride as a catalyst. Dichloromethane and chloroform were purchased from China National Pharmaceutical Group Chemical Reagent Company; α-cyclodextrin (suitable for cell culture, ≥98%) was provided by Sigma-Aldrich Co., Ltd.; bFGF and bFGF Elisa assay kits were provided by R&D Company supply. Other high-grade pure chemical reagents were purchased from China Pharmaceutical Reagent Co., Ltd. (Shanghai, China).

[0037] b) Fabrication of bFGF-loaded PLGA fiber membranes

[0038] bFGF (100 μL, 20 μg / ml) was dissolved in 0.6 ml phosphate buffered saline (PBS, 50 mM, pH 7.4) containing 76 mg / ml cyclodextrin. This 0.7...

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Abstract

The present invention provides application of a nanofiber membrane in preparation of a rotator cuff injury treatment material, the nanofiber membrane is an electrospinning fiber membrane to promote cell growth, the nanofiber membrane optimization preferably includes cytokines, a pharmaceutical excipient and a biodegradable polymer material, the mass ratio of cytokines to pharmaceutical excipient is (0.05-0.5) : (1000-10000), and the mass ratio of cytokines to biodegradable polymer material is (0.5-0.9) : (500-10000). The present invention provides a new use of the nanofiber membrane, the nanofiber membrane is used for preparation of the rotator cuff injury treatment material, the nanofiber membrane has good biocompatibility and biodegradability, can promote cell adhesion and regeneration, accelerates the remodeling of tendon bone area, promotes the healing of the tendon bone, can effectively promote the regeneration of the injured rotator cuff, is non-toxic, non-immunogenicity, and small in side effects, and has great significance in clinic.

Description

technical field [0001] The invention relates to the application of a nanofiber membrane in preparing a material for treating rotator cuff injury. Background technique [0002] The rotator cuff is a general term for the subscapularis, supraspinatus, infraspinatus, teres minor and other musculature covering the front, upper and rear of the shoulder joint. It is located below the acromion and deltoid and is closely connected to the joint capsule. The function of the rotator cuff is to draw the humeral head closer to the glenoid during the abduction of the upper arm and maintain the normal anatomical relationship between the humeral head and the glenoid. Rotator cuff injury will weaken or even lose this function, seriously affecting the abduction of the upper extremity. Rotator cuff tears are one of the most common clinical injuries that can cause pain, limited shoulder function, and decreased muscle strength. [0003] Although surgical techniques have developed rapidly in re...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/14A61L31/16D01F1/10
Inventor 赵金忠赵松崔文国
Owner 赵金忠
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