Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of nanofiber membrane in preparation of rotator cuff injury treatment material

A nanofiber membrane, rotator cuff injury technology, applied in the fields of fiber chemical characteristics, rayon manufacturing, medical science, etc., can solve the problems of the safety of viral vectors, restricting effects, etc., and achieve good biocompatibility and biodegradation. Sex, promotes healing, accelerates remodeling

Inactive Publication Date: 2015-08-19
赵金忠 +2
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods can also play a certain role, because the growth factor can only maintain activity for a short period of time, thus limiting its effect
Genetic engineering offers a route to generate relevant growth factors, but safety of use of viral vectors remains controversial

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of nanofiber membrane in preparation of rotator cuff injury treatment material
  • Application of nanofiber membrane in preparation of rotator cuff injury treatment material
  • Application of nanofiber membrane in preparation of rotator cuff injury treatment material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] The present invention will be further described below with reference to the accompanying drawings and specific embodiments to better understand the present invention.

[0034] 1. Preparation of Nanofibrous Membranes

[0035] a) Materials

[0036] Polylactic acid-glycolic acid is prepared by the ring-opening polymerization of lactide and glycolide, using tin chloride as a catalyst. Dichloromethane and chloroform were purchased from China National Pharmaceutical Group Chemical Reagent Company; α-cyclodextrin (suitable for cell culture, ≥98%) was provided by Sigma-Aldrich Co., Ltd.; bFGF and bFGF Elisa assay kits were provided by R&D Company supply. Other high-grade pure chemical reagents were purchased from China Pharmaceutical Reagent Co., Ltd. (Shanghai, China).

[0037] b) Fabrication of bFGF-loaded PLGA fiber membranes

[0038] bFGF (100 μL, 20 μg / ml) was dissolved in 0.6 ml phosphate buffered saline (PBS, 50 mM, pH 7.4) containing 76 mg / ml cyclodextrin. This 0.7...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides application of a nanofiber membrane in preparation of a rotator cuff injury treatment material, the nanofiber membrane is an electrospinning fiber membrane to promote cell growth, the nanofiber membrane optimization preferably includes cytokines, a pharmaceutical excipient and a biodegradable polymer material, the mass ratio of cytokines to pharmaceutical excipient is (0.05-0.5) : (1000-10000), and the mass ratio of cytokines to biodegradable polymer material is (0.5-0.9) : (500-10000). The present invention provides a new use of the nanofiber membrane, the nanofiber membrane is used for preparation of the rotator cuff injury treatment material, the nanofiber membrane has good biocompatibility and biodegradability, can promote cell adhesion and regeneration, accelerates the remodeling of tendon bone area, promotes the healing of the tendon bone, can effectively promote the regeneration of the injured rotator cuff, is non-toxic, non-immunogenicity, and small in side effects, and has great significance in clinic.

Description

technical field [0001] The invention relates to the application of a nanofiber membrane in preparing a material for treating rotator cuff injury. Background technique [0002] The rotator cuff is a general term for the subscapularis, supraspinatus, infraspinatus, teres minor and other musculature covering the front, upper and rear of the shoulder joint. It is located below the acromion and deltoid and is closely connected to the joint capsule. The function of the rotator cuff is to draw the humeral head closer to the glenoid during the abduction of the upper arm and maintain the normal anatomical relationship between the humeral head and the glenoid. Rotator cuff injury will weaken or even lose this function, seriously affecting the abduction of the upper extremity. Rotator cuff tears are one of the most common clinical injuries that can cause pain, limited shoulder function, and decreased muscle strength. [0003] Although surgical techniques have developed rapidly in re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/06A61L31/14A61L31/16D01F1/10
Inventor 赵金忠赵松崔文国
Owner 赵金忠
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com