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A kind of gel for treating herpes zoster and preparation method thereof

The technology of herpes zoster and gel is applied in the field of gel for the treatment of herpes zoster and the field of preparation thereof, which can solve the problems of virus resistance, irrelevance to treatment, adverse reactions and the like, so as to accelerate the repair of damaged nerves , No skin irritation, pain relief effect

Active Publication Date: 2018-05-01
济南众志康成药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a large dose can easily lead to drug resistance of the virus, and it often brings adverse reactions not related to treatment

Method used

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  • A kind of gel for treating herpes zoster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation that is used for the treatment of the gel of herpes zoster

[0029] Formula: Acyclovir 3%, Lidocaine Hydrochloride 2%, Tacrolimus 0.1%, Vitamin B12 0.05%, Gel Matrix 1%, Neutralizer 1.2%, Humectant 5%, Solvent 30%, 2% solubilizer, 1% absorption promoter, and the balance is water;

[0030] The gel matrix is ​​carbomer 940; the neutralizing agent is triethanolamine; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizing agent is Tween 80;

[0031] Preparation:

[0032] (1) Take the gel matrix of the prescribed amount, add 30 times the weight of water to dissolve, add a neutralizer dropwise to adjust the pH value to 5.5-6.0;

[0033] (2) Get another prescription amount of lidocaine hydrochloride and vitamin B12, add 5 times the weight of water to dissolve;

[0034] (3) Acyclovir and tacrolimus are dissolved in a solvent, and then a moisturizing agent is added;

[0035] (4) Add the solution of step (2) and step (3) to ...

Embodiment 2

[0036] Embodiment 2: the preparation that is used for the treatment of the gel of herpes zoster

[0037] Formula: Acyclovir 2%, Lidocaine Hydrochloride 3%, Tacrolimus 0.05%, Vitamin B12 0.06%, Gel Matrix 0.5%, Neutralizer 1.5%, Humectant 4%, Solvent 35%, 1% solubilizer, 1.5% absorption accelerator, and the balance is water.

[0038] The gel matrix is ​​carbomer 940; the neutralizing agent is triethanolamine; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizing agent is Tween 80;

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0040] Embodiment 3: the preparation that is used for the treatment of the gel of herpes zoster

[0041] Acyclovir 4%, Lidocaine Hydrochloride 1%, Tacrolimus 0.15%, Vitamin B12 0.04%, Gel Matrix 1.5%, Neutralizer 1.5%, Humectant 6%, Solvent 25%, Solubilizer 3%, 0.5% of absorption-promoting agent, and the balance is water.

[0042] The gel base is carbomer 940; the neutralizing agent is triethanolamine; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizing agent is Tween 80;

[0043] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a gel for treating herpes zoster, which is made of the following raw materials in percentage by weight: acyclovir 2-4%, lidocaine hydrochloride 1-3%, tacrolimus 0.05‑0.15%, vitamin B12 0.04‑0.06%, gel base 0.5‑1.5%, neutralizer 1‑1.5%, humectant 4‑6%, solvent 25‑35%, solubilizer 1‑3%, absorption enhancer 0.5-1.5%, the balance is water; the gel matrix is ​​one or more of carbomer 940, hydroxypropyl methylcellulose, alginate, gelatin or starch; the neutralization The agent is triethanolamine or sodium hydroxide; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizer is Tween 80; the absorption-promoting agent is laurocapram; The preparation method of the agent. Each drug component in the gel of the invention has a synergistic effect, can reduce the usage amount of the drug, and reduce the adverse reaction of the drug.

Description

technical field [0001] The invention relates to a gel for treating herpes zoster and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Shingles is a skin disease caused by a virus that can occur anywhere on the body. It is more likely to occur in the distribution areas of the trigeminal nerve, vertebral nerve, intercostal nerve and lumbosacral nerve. Because it invades the nerve, the patient suffers from unbearable pain, so timely treatment is especially important. [0003] Clinically, antiviral drugs for the treatment of herpes zoster mainly include ribavirin, acyclovir, valaciclovir, valacyclovir, and penciclovir. In the process of treating herpes zoster, the above-mentioned drugs exert their medicinal effects by directly acting on the virus, and exhibit antiviral activity by inhibiting the replication of viral DNA or acting on enzymes related to DNA replication. [0004] However, viruses have str...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/522A61K9/06A61P31/22A61P29/00A61K31/167A61K31/436A61K31/51
Inventor 李绍文戴晓莉
Owner 济南众志康成药物研发有限公司
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