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Preparation method for detachable esophageal stent

A technology of esophagus and braided sheet, which is applied in the field of preparation of decomposable esophageal stents, which can solve the problems of unguaranteed treatment effect and short maintenance time, and achieve the effect of good radial support force and wide application range

Inactive Publication Date: 2015-09-23
SHANDONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, balloon dilatation is mostly used, but the maintenance time of this method is relatively short, requiring multiple expansions, and the duration lasts for 4 to 8 weeks. While causing a lot of pain to the patient, it cannot guarantee a good therapeutic effect.

Method used

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  • Preparation method for detachable esophageal stent
  • Preparation method for detachable esophageal stent
  • Preparation method for detachable esophageal stent

Examples

Experimental program
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Effect test

preparation example Construction

[0024] The present invention also includes a method for preparing a decomposable esophageal stent, comprising the following steps:

[0025] ① Use lactide and glycolide as raw materials to synthesize poly(lactic acid-glycolic acid) copolymer;

[0026] ② extruding and stretching the poly(lactic acid-glycolic acid) copolymer obtained in step ① to obtain stretched filaments;

[0027] ③ Making the stent alloy wire braided sheet, heat-treating it, and then coating it to obtain the film-coated woven sheet; the stent alloy wire braided sheet uses a rhombus weaving method; the temperature of the heat treatment is 510-600°C, and the time is 20 ~30 minutes; the specific step of the coating film treatment is to soak the heat-treated stent alloy wire braided sheet with absolute alcohol for 1 to 2 minutes, then dry it, immerse it in a silicone rubber solution with a mass fraction of 5~10%, and coat Cover evenly, take it out and dry it in a drying oven, put it in an oven and dry it at 120°C...

Embodiment 1

[0033] A decomposable esophageal stent, consisting of three stent alloy wire braided sheets, the surface of the stent alloy wire braided sheet is coated with a layer of silicone rubber, and the stent alloy wire braided sheet is made of poly(lactic acid-glycolic acid) copolymerized The objects are connected by suture, and the composition material of the stent alloy wire braid is nickel-titanium memory alloy.

[0034] ① Use lactide and glycolide as raw materials to synthesize poly(lactic acid-glycolic acid) copolymer;

[0035] ② extruding and stretching the poly(lactic acid-glycolic acid) obtained in step ① to obtain stretched silk;

[0036] ③ Making the stent alloy wire braided sheet, heat-treating it, and then coating it to obtain the coated woven sheet; the stent alloy wire braided sheet uses a rhombus weaving method; the temperature of the heat treatment is 510° C., and the time is 20 minutes; The specific steps of the coating film treatment are soaking the heat-treated ste...

Embodiment 2

[0039] A decomposable esophageal stent, consisting of three stent alloy wire braided sheets, the surface of the stent alloy wire braided sheet is coated with a layer of silicone rubber, and the stent alloy wire braided sheet is made of poly(lactic acid-glycolic acid) copolymerized The objects are connected by suture, and the composition material of the stent alloy wire braid is nickel-titanium memory alloy.

[0040] ① Use lactide and glycolide as raw materials to synthesize poly(lactic acid-glycolic acid) copolymer;

[0041] ② extruding and stretching the poly(lactic acid-glycolic acid) obtained in step ① to obtain stretched silk;

[0042] ③ Making the stent alloy wire braided sheet, heat-treating it, and then coating it to obtain the film-coated woven sheet; the stent alloy wire braided sheet uses a rhombus weaving method; the temperature of the heat treatment is 600° C., and the time is 30 minutes; The specific steps of the coating film treatment are soaking the heat-tre...

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Abstract

The invention discloses a detachable esophageal stent and a preparation method thereof. The detachable esophageal stent consists of three bracket alloy wire weaving sheets; the surfaces of the bracket alloy wire weaving sheets are coated with a layer of silicon rubber; the bracket alloy wire weaving sheets are connected in a seaming manner through poly(lactic acid-hydroxyacetic acid) copolymer (PLGA) and are prepared from nickel-titanium memory alloy. The invention discloses all technologies of synthesis, extrusion processing and stretching filamentation of PLGA and discloses technologies for weaving, coating and connecting the detachable esophageal stent. The detachable esophageal stent keeps the characteristic of high radial supporting force of a metal bracket and has the biological degradability of a degrading material; the detaching of the bracket is controlled by regulating the degrading time of PLGA, so that the aims of provisionality and periodicity which are clinically required are fulfilled; a brand new measure and a method are provided for treatment of benign esophageal stricture.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a preparation method of a decomposable esophageal stent. Background technique [0002] Esophageal stricture is a relatively common digestive tract disease in clinical practice. According to the cause of the disease, it can be divided into two categories: benign and malignant esophageal stricture. At present, the esophageal stents used in clinical treatment are mostly nickel-titanium alloy covered stents, which are used as a palliative therapy to treat malignant digestive tract diseases. Because this type of permanent stent remains in the body for a long time to form foreign bodies, it can cause chronic damage to the esophagus, which is more likely to cause intimal hyperplasia, inner muscle atrophy, and even the formation of aneurysms, and can even cause restenosis of the esophagus, which may endanger the esophagus in severe cases. patient's life and health. Due to the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/02A61L31/14
Inventor 刘阳冯圣玉王传栋王勤李俊起
Owner SHANDONG UNIV
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