Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Injectable artificial bone of compound micro capsule artificial cells

A technology of artificial cells and microencapsulation, which is applied in the fields of medical science and prostheses, can solve the problems of slow healing and slow recovery of bone wounds, and achieve the effects of reducing trauma, relieving pain, and avoiding displacement of fracture fragments

Active Publication Date: 2015-09-30
天津顺永泰锦科技有限公司
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, this kind of bone graft material also has the disadvantages of slow healing and slow recovery of bone wounds.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] An injectable artificial bone with composite microencapsulated artificial cells, including solid phase components, liquid phase components and microencapsulated artificial cell components. The solid phase components include calcium carbonate, (-tricalcium phosphate and calcium hydrogen phosphate) , The liquid phase component includes sodium hydrogen phosphate aqueous solution, the microencapsulated artificial cell component includes microbead capsules, which are composed of sodium alginate-polylysine-sodium alginate microcapsules encapsulating human bone marrow mesenchymal stem cells It has been tested that the artificial bone of the present invention can be easily and completely injected from an injection needle with a length of 25 cm and an inner diameter of 1.5 mm, making it possible to use a minimally invasive method of percutaneous injection to fill bone defects. There are microbead capsules on the capsule wall Pores, and the capsule wall of the microbead capsule has...

Embodiment 2

[0032] An injectable artificial bone with composite microencapsulated artificial cells, including solid phase components, liquid phase components and microencapsulated artificial cell components. The solid phase components include calcium carbonate, α-tricalcium phosphate and calcium hydrogen phosphate , The solid phase component also includes calcium sulfate. The mass percentages of calcium carbonate, α-tricalcium phosphate, calcium hydrogen phosphate and calcium sulfate in the solid phase component are: calcium carbonate 10.4% and α-tricalcium phosphate 62.7 %, calcium dihydrogen phosphate 2.4% and calcium sulfate 20%;

[0033] The liquid phase components include disodium hydrogen phosphate aqueous solution and hydroxypropyl methyl cellulose. The mass concentrations of disodium hydrogen phosphate and hydroxypropyl methyl cellulose in the liquid phase components are: disodium hydrogen phosphate 28.4%, hydroxypropyl methylcellulose. Propyl methyl cellulose 2%;

[0034] The four co...

Embodiment 3

[0046] The method of using the above composite microencapsulated artificial cell injectable artificial bone is to first mix the liquid phase component and the microencapsulated artificial cell component, and then mix with the solid phase, quickly move to the syringe, and then pass the corresponding injection needle. It can be injected into the affected area, and the cement can be shaped arbitrarily during this period. After about 10 minutes, the artificial bone has reached the initial solidification, and then it cannot be shaped, otherwise it will break and affect the strength after solidification. The final solidification is reached in about 15-20 minutes, the artificial bone solidifies to a certain strength, and the wound can be sutured. The curing strength reaches its peak at 7 days, which is similar to the strength of cancellous bone. It can be applied to fractures and bone defects in the cancellous bone of the metaphysis, such as distal radius, proximal tibia, distal femur...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an injectable artificial bone of compound micro capsule artificial cells. The injectable artificial bone of the compound micro capsule artificial cells is characterized by comprising a solid phase component, a liquid phase component and a micro capsule artificial cell component, wherein the solid phase component comprises calcium carbonate, alpha (Alpha)-tricalcium phosphate and calcium hydrophosphate, the liquid phase component comprises sodium phosphate dibasic, the micro capsule artificial cell component comprises a bead capsule, the bead capsule is formed by packing human mesenchymal stem cells through sodium alginate- polylysine-alginate microcapsules. Compared with the prior art, the injectable artificial bone of the compound micro capsule artificial cells can be widely applied in the fields of traumatic orthopedics, spine surgery, bone tumour, departments of stomatology and orthopedic surgery and the like, can replace bone grafting by filling bone defects through skin injection, reduces trauma through minimally invasive treatment, reduces pain of patients, speeds up healing of damaged positions, reduces dosage of internal fixation, stabilizes fracture blocks in early stage, enables the patients to train functions in early stage, and prevents ankylosis and shifting of the fracture blocks.

Description

Technical field [0001] The present invention relates to the field of injectable artificial bone, in particular to an injectable artificial bone with composite microencapsulated artificial cells. Background technique [0002] Tissue engineering technology can make inanimate materials composite with living cells and turn them into living transplant substitute materials, which is the mainstream direction of life science development today. [0003] At present, commonly used bone graft materials include autologous bone, allogeneic bone, hydroxyapatite, ceramics, coral and so on. Because these materials are solid, a long trimming process is required during the operation to adapt to the shape of the bone defect for filling, and a larger incision is required to expose the bone graft material to fill the bone defect during application, and minimally invasive treatment is not possible. More traumatic. Calcium phosphate cement (CPC) family material is a new type of bone transfer material th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/12A61L27/20A61L27/04A61L27/36A61L27/50A61L27/56
Inventor 苗军
Owner 天津顺永泰锦科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com