Triple-hybrid yolk-shell structured mesoporous organic silica and preparation method thereof

A technology based on organic silicon oxide and triethoxy silicon, which is applied in the field of nanomaterials, can solve problems such as singleness, and achieve the effect of low cost and low equipment requirements

Inactive Publication Date: 2015-11-11
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fluorescent molecules can be further modified by introducing thioether groups for biomedical imaging (Yolk-Shell Structured Mesoporous Nanoparticles with Thioether-2 Bridged Organosilica Frameworks. Chemistry of Materials, 2013, 25(1): 98-105.IF=8.535), but currently the egg yolk-eggshell structure The organic functional groups in organosilica are all of a single type
Mesoporous organosilicon with egg yolk-eggshell structure with various organosilicas has not been reported or patented yet

Method used

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  • Triple-hybrid yolk-shell structured mesoporous organic silica and preparation method thereof
  • Triple-hybrid yolk-shell structured mesoporous organic silica and preparation method thereof
  • Triple-hybrid yolk-shell structured mesoporous organic silica and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Mix 1ml of concentrated ammonia water (the NH contained in the concentrated ammonia water 3The mass percent concentration is 25%) mixed with 30ml ethanol and 75ml water, then 0.16g hexadecyltrimethylammonium bromide solution was added to the mixed solution, and 0.125ml orthosilicon Acid tetraethyl ester, 0.4ml of 1,2-bis(triethoxysilyl)ethane, 0.1ml of bis[γ-(triethoxysilyl)propyl]tetrasulfide and 0.1ml of 1, A mixture of 2-bis(triethoxysilyl)benzene was added to the aqueous alcohol solution, namely tetraethylorthosilicate, 1,2-bis(triethoxysilyl)ethane, bis[γ-( The molar ratio of triethoxysilyl) propyl] tetrasulfide and 1,2-bis(triethoxysilyl) benzene, surfactant, water and ethanol is 1:1.9:0.36:0.45:0.8: 7455:922, reacted for 12h to obtain a white solution;

[0034] (2) Centrifuge the white solution obtained in step (1), wash it with water, and transfer it to water to prepare an organic silicon oxide dispersion, and place it at 70°C for 24 hours;

[0035] (3) T...

Embodiment 2

[0038] (1) Mix 1ml of concentrated ammonia water (the NH contained in the concentrated ammonia water 3 The mass percent concentration is 25%) mixed with 33ml ethanol and 120ml water, then 1.3g hexadecyltrimethylammonium bromide was dissolved in the mixed solution, and 0.125ml orthosilicon Acid tetraethyl ester, 0.62ml of 1,2-bis(triethoxysilyl)ethane, 0.28ml of bis[γ-(triethoxysilyl)propyl]tetrasulfide and 0.22ml of 1, A mixture of 2-bis(triethoxysilyl)benzene was added to the aqueous alcohol solution, namely tetraethylorthosilicate, 1,2-bis(triethoxysilyl)ethane, bis[γ-( The molar ratio of triethoxysilyl)propyl]tetrasulfide and 1,2-bis(triethoxysilyl)benzene, surfactant, water and ethanol is 1:3.0:1:1.0:6.5: 12000:1000, reacted for 24h, and obtained a white solution;

[0039] (2) Centrifuge the white solution obtained in step (1), wash it with water, and transfer it to water to prepare an organic silicon oxide dispersion, and place it at 50°C for 12 hours;

[0040] (3) The...

Embodiment 3

[0043] (1) Mix 1ml of concentrated ammonia water (the NH contained in the concentrated ammonia water 3 The mass percent concentration is 25%) mixed with 30ml ethanol and 95ml water, then 0.16g hexadecyltrimethylammonium bromide was dissolved in the mixed solution, and 0.125ml orthosilicon Tetraethyl ester, 0.2ml of 1,2-bis(triethoxysilyl)ethane, 0.1ml of bis[γ-(triethoxysilyl)propyl]tetrasulfide and 0.1ml of 1, A mixture of 2-bis(triethoxysilyl)benzene was added to the aqueous alcohol solution, namely tetraethylorthosilicate, 1,2-bis(triethoxysilyl)ethane, bis[γ-( The molar ratio of triethoxysilyl) propyl] tetrasulfide and 1,2-bis (triethoxysilyl) benzene, surfactant, water and ethanol is 1:0.97:0.36:0.45:0.8: 7455:922, reacted for 24h to obtain a white solution;

[0044] (2) Centrifuge the white solution obtained in step (1), wash it with water, and transfer it to water to prepare an organic silicon oxide dispersion, and place it at 40°C for 24 hours;

[0045] (3) The reac...

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Abstract

The invention discloses a triple-hybrid yolk-shell structured mesoporous organic silica and a preparation method thereof. A framework of the silica comprises three bridged organic silicas and is in the shape of a spheroid which has a core-shell structure; both a core and a shell layer are provided with mesoporous channels, and a cavity structure is provided between the core and the shell layer. The preparation method includes: dissolving a surfactant in a mixed solution of ammonia-containing ethyl alcohol and water, and adding tetraethyl orthosilicate and three bridged organic silica precursors under heating and stirring; after a period of time of reaction, subjecting obtained solid organic silica to hydrothermal treatment to form a yolk-shell structure, and finally removing the surfactant to obtain triple-hybrid yolk-shell structured mesoporous organic silica nanospheres. The preparation method has a simple technical process, and products prepared have great potential of application in the fields of drug delivery, environmental treatment and the like.

Description

technical field [0001] The invention relates to a triple hybrid egg yolk-eggshell structure mesoporous organic silicon oxide and a preparation method thereof, belonging to the field of nanometer materials. Background technique [0002] Mesoporous silica nanoparticles have broad application prospects in the fields of drug delivery, catalysis, and pollutant treatment. However, the single O-Si-O framework component of silica limits the performance and application of mesoporous silica materials. By introducing organic groups, the properties of silica can be adjusted to promote its transformation and application. Initially, people used post-modification technology to introduce organic groups into the pores and particle surfaces of mesoporous silica to improve the performance of silica and derive new active centers. However, the organic functionalized mesoporous silica prepared by this method has uneven organic groups, which will occupy the pores and reduce the pore volume. To ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/24A61K49/00A61K47/54
Inventor 苏晓丹张俊杰汪联辉翁丽星滕兆刚
Owner NANJING UNIV OF POSTS & TELECOMM
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