3D bio-printing medical dressing and preparation method thereof

A bioprinting and biomaterial technology, applied in the field of biomedical material preparation, can solve problems such as poor moisturizing and hemostasis, bacterial growth, wound adhesion, etc., and achieve the effects of promoting wound healing, good air permeability, and good water absorption.

Inactive Publication Date: 2015-11-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings mainly refer to natural fiber materials such as absorbent cotton gauze, gauze strips, cotton balls and cotton membranes, which can dry the wound and have the function of physical isolation; Trauma, as well as problems such as bacterial growth, poor moisturizing and hemostatic performance

Method used

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  • 3D bio-printing medical dressing and preparation method thereof
  • 3D bio-printing medical dressing and preparation method thereof
  • 3D bio-printing medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Utilize computer-aided design (CAD) software to design a three-dimensional structural model of the wound dressing, and save the three-dimensional model as an STL format file, then import it into a three-dimensional printer, and perform layering processing with layering software;

[0029] (2) Add 15g of decellularized collagen to 100ml of deionized water, stir for 2 hours until completely dissolved to obtain an aqueous solution of decellularized collagen, filter it, add the filtrate into the barrel of the 3D printer, centrifuge and let it stand for 24 hours; in the VisualMachines software Set the printing temperature to room temperature, platform temperature to 10°C, needle size to 0.3mm, extrusion pressure to 1.2bar, extrusion speed to 3.0mm / s, hole diameter to 0.8mm, and internal structure to 0° and 90°staggered arrangement , with a layer thickness of 0.24mm; then start the 3D printer to print the 3D structure model of the wound dressing with a regular porous struct...

Embodiment 2

[0032] (1) Utilize computer-aided design (CAD) software to design a three-dimensional structural model of the wound dressing, and save the three-dimensional model as an STL format file, then import it into a three-dimensional printer, and perform layering processing with layering software;

[0033] (2) Add 10g of decellularized collagen and 3g of sodium alginate into 100ml of deionized water, stir for 2 hours until completely dissolved to obtain a mixed aqueous solution of decellularized collagen and sodium alginate, then filter it, and add the filtrate to the barrel of the 3D printer , and let stand for 24 hours after centrifugation; then in the VisualMachines software, set the printing temperature to room temperature, platform temperature to 10°C, needle size to 0.2mm, extrusion pressure to 2.8bar, extrusion speed to 1.5mm / s, and aperture to 0.5 mm, set the internal structure to be staggered at 0° and 90°, and the layer thickness is 0.16mm; then start the 3D printer to print ...

Embodiment 3

[0036] (1) Utilize computer-aided design (CAD) software to design a three-dimensional structural model of the wound dressing, and save the three-dimensional model as an STL format file, then import it into a three-dimensional printer, and perform layering processing with layering software;

[0037] (2) Add 10g of decellularized collagen and 3g of hyaluronic acid into 100ml of deionized water, stir for 2 hours until completely dissolved to obtain a mixed aqueous solution of decellularized collagen and hyaluronic acid, then filter it, and add the filtrate to the barrel of the 3D printer , after centrifugation, let it stand for 24 hours; then set the printing temperature to room temperature, the platform temperature to 5°C, the needle size to 0.4mm, the extrusion pressure to 1.0bar, the extrusion speed to 4.0mm / s, and the aperture to 0.8 in the VisualMachines software. mm, set the internal structure to be staggered at 0° and 90°, and the layer thickness is 0.32mm; then start the 3...

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Abstract

The invention discloses a 3D bio-printing medical dressing and a preparation method thereof. The medical dressing takes cell-free collagen as a main component and is prepared by a rapid prototyping technology. According to the invention, the medical dressing prepared from a bio-material containing cell-free collagen has the advantages of good biocompatibility, no toxic or side effect and no immunological rejection; meanwhile, by using the rapid prototyping technology for preparing the dressing with a 3D structure, the preparation process is convenient and fast, the operation steps are simple, the geometric shape, pore diameter, porosity and pore distribution of the dressing can be accurately controlled according to wound sizes of different patients and the characteristics of the material, and thus personalized medical dressings with good air permeability and hydroscopic property for patients can be prepared.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a 3D bioprinted medical dressing and a preparation method thereof. Background technique [0002] The main function of medical dressings is to serve as a wound cover. During the wound healing process, it replaces the damaged skin to act as a temporary barrier, avoids or controls wound infection, and provides an environment conducive to wound healing. Traditional dressings mainly refer to natural fiber materials such as absorbent cotton gauze, gauze strips, cotton balls and cotton membranes, which can dry the wound and have the function of physical isolation; Trauma, as well as problems such as bacterial growth, poor moisturizing and hemostatic performance. In 1962, the British Winter proposed the "moist wound healing theory", that is, wounds heal faster in a moist environment than in a dry environment, which made a breakthrough in people's ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/32A61L15/28A61L15/18A61L15/26B33Y10/00B33Y80/00
Inventor 魏坤胡露
Owner SOUTH CHINA UNIV OF TECH
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