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Cosmetic compositions and methods providing enhanced penetration of skin care actives

A technology of cosmetic composition and compound, applied in the direction of cosmetics, cosmetic preparations, skin care preparations, etc., which can solve the problems that have not been well studied and difficult to choose penetration enhancers

Active Publication Date: 2015-11-11
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even more recently, Williams and Barry in "Penetration enhancers", Advanced Drug Delivery Reviews, Vol. 64, pp. 128-137 (2012) suggested that "for a given penetration, it is difficult to rationally select a penetration enhancer"
While the effect of certain individual ingredients on skin penetration has been studied to some extent, the possible role of combinations of ingredients in enhancing the penetration of cosmetic agents into and through the stratum corneum appears to have not even been well studied, including ingredient concentration, The extent to which changes in ratios and / or combinations may affect the penetration of cosmetic skin ingredients

Method used

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  • Cosmetic compositions and methods providing enhanced penetration of skin care actives
  • Cosmetic compositions and methods providing enhanced penetration of skin care actives
  • Cosmetic compositions and methods providing enhanced penetration of skin care actives

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0129] Example 1 - Nicotinamide / Glycerol Assay

[0130] An in vitro skin penetration study was performed to characterize the effect of glycerol on the in vitro skin penetration of radioisotope-labeled nicotinamide in several cosmetic compositions. The kinetics of in vitro skin penetration of radiolabeled nicotinamide was determined at fixed glycerol concentrations, and the effect of glycerol and nicotinamide product concentrations on skin penetration of radiolabeled nicotinamide and glycerol over 6 hours was determined. Table 9 provides a general description of the four cosmetic composition types tested. It should be noted that the individual products used in the study may have specific concentrations that differ slightly from the general values ​​in Table 8. Additionally, Composition #1 was repeated in two different studies, varying the concentrations of nicotinamide and glycerol.

[0131] Table 8: General description of substrates used in in vitro skin penetration expe...

example 2

[0141] Example 2 - Niacinamide / Glycerol / Hexyldecanol Test

[0142] Cosmetic compositions as described in Table 8 were prepared.

[0143] Table 9

[0144]

[0145] The Phase A components are mixed together using a suitable mixer (eg model Tekmar RW20DZM) and paddle stirring while heating to about 50C. Continue mixing until all of the crosslinked polymer is visually uniformly dispersed. Add Phase B components to Phase A with continued mixing and allow Phase A to cool to room temperature. Add Phase C to Phase A / B with constant stirring. If desired, add the components of Phases D and E, then mill using a Tekmar T-25, and mill the product at about 8000 rpm for 5 minutes. Add Phase F to Phases A-E and mix using a suitable mixer for about 5 minutes.

[0146] Next, the human cadaver skin samples were fixed in a standard Franz-type diffusion cell (0.79 cm) maintained at about 37°C 2 surface area). Six replicates were prepared for each composition group. The receiver comp...

example 3

[0148] Example 3 - Niacinamide / Glycerin / Hexyldecanol / Diol Test

[0149] The cosmetic compositions shown in Table 10 were prepared in the same manner as described in Example 2 above.

[0150] Table 10

[0151]

[0152] Using generally the same test method as described in Example 2, the DPM for each compartment of each cell was blank corrected and summed to obtain the total recovered radiolabel value for a given cell. The DPM of each compartment was then normalized to the total recovered radiolabel value to obtain the "% recovered radiolabel" parameter for each compartment (separate receiver collections, epidermis, dermis and wipes for mass balance) . The cumulative receiver value for each collection time point is calculated as the sum of the individual collections up to that time point, where the total receiver value is calculated as the sum of all the individual collections. The total percent recovery value is the sum of the epidermal (including stratum corneum) and ...

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PUM

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Abstract

A cosmetic composition suitable for topical application is provided. In some examples, the cosmetic composition can include glycerin, hexyldecanol, a vitamin B compound, and one or more materials selected from the group consisting of 1,2-pentanediol, 1,4-pentanediol, 2,4-pentanediol, 1,5-pentanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, 2,5-hexanediol, hexylene glycol, and combinations thereof.

Description

technical field [0001] The present invention provides cosmetic compositions that provide enhanced penetration of skin care actives and methods of their associated use. Background technique [0002] Vitamin B compounds such as niacinamide are well known cosmetic skin care agents believed to provide a variety of skin care benefits (see, e.g., "Niacinamide: AB Vitamin that Improves Aging Facial Skin Appearance" by Bissett et al. and "Clinical Situations Conducive to Proactive Skin Health and Anti-Aging Improvement" by Draelos). Some reported benefits include improvements in facial skin texture appearance, erythema, hyperpigmentation, and enhancement of skin barrier function. In view of these benefits, there is a continuing desire to increase the amount of vitamin B compounds delivered into human skin by topically applied cosmetic compositions to further enhance the skin benefits provided by these compounds. [0003] It is known that the rate-limiting step of percutaneous absor...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/67A61Q17/00A61Q19/00
CPCA61K47/10A61K8/342A61K8/345A61K8/675A61K31/455A61Q19/00
Inventor S·D·琼斯K·V·古吉拉提吉见直久M·保罗J·T·威斯克特
Owner THE PROCTER & GAMBLE COMPANY
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