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Thermo-sensitive polymer carrier and preparation method and application thereof

A temperature-sensitive polymer and carrier technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of low film stability and bioavailability, and achieve simple process, cheap raw materials, strong resistance The effect of protein adsorption performance

Inactive Publication Date: 2015-12-23
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this application is limited by the low membrane stability and bioavailability of liposomes

Method used

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  • Thermo-sensitive polymer carrier and preparation method and application thereof
  • Thermo-sensitive polymer carrier and preparation method and application thereof
  • Thermo-sensitive polymer carrier and preparation method and application thereof

Examples

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preparation example Construction

[0031] The preparation method of the above-mentioned temperature-sensitive polymer carrier comprises the following steps: (a) dissolving monomer A, monomer B and initiator in the first solvent, stirring and reacting at 65-75°C under anaerobic conditions After 70-74 hours, a sulfobetaine-adenine solution is obtained; (b) pour the sulfobetaine-adenine solution into a precipitant, filter and dry. The first solvent is preferably dimethyl sulfoxide, the precipitating agent is preferably acetone, and the initiator can be selected from existing ones, and its amount is determined according to the total amount of monomer A and monomer B.

[0032] The preparation method of the monomer B comprises the following steps: (S1) dissolving 2-bromoethanol, methacryloyl chloride and triethylamine in dichloromethane, stirring and reacting for 17.5-18.5 hours to obtain a mixed solution; (S2) filtering Described mixed solution, after adding ice-water mixing in filtrate, leave standstill sealing lay...

Embodiment 1

[0036] This embodiment provides a thermosensitive polymer carrier, which is prepared as figure 1 As shown, specifically: according to the molar ratio of 1:1, 0.35mmol SBMA (structural formula as figure 1 Shown, American Sigma Company, 97%), 0.35mmolAEM (structural formula such as figure 1As shown, Shanghai Bailingwei Company, 98%), 0.0055g AIBN (Sinopharm Chemical Reagent Co., Ltd., chemically pure) were added to 4.0mL of anhydrous DMSO (Sinopharm Chemical Reagent Co., Ltd., purity ≥ 99.0%), at room temperature Stir until the solute is completely dissolved to obtain a mixed solution; put the above mixed solution in an ampule bottle, pass through argon to remove dissolved oxygen, then seal it and put it in an oil bath at 70°C, and react for 72 hours; the product after the reaction Precipitate three times with acetone and dry under vacuum to obtain a polymer, abbreviated as P(SBMA-co-AEM), which is characterized as image 3 and Figure 4 as shown, image 3 (A) is 1H-NMR (400...

Embodiment 2

[0057] This example provides a temperature-sensitive polymer carrier, the preparation method of which is basically the same as that in Example 1, except that the molar ratio of monomer A to monomer B is 3:1.

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Abstract

The invention relates to a thermo-sensitive polymer carrier and a preparation method and application thereof. The thermo-sensitive polymer carrier is formed by copolymerization of a monomer A and a monomer B under the action of initiator. Please see the chemical structural formula of the monomer A in specification, and please see the chemical structural formula of the monomer B in specification. Amphiphilic ionic functional groups are introduced into a molecular structure of the thermo-sensitive polymer carrier, the pollution-free nature of the surfaces of nano-particles is created, high protein adsorption resistance property is achieved, the property of thermo-sensitive response is achieved, and the functions of low-temperature packing and high-temperature medicine fast releasing are achieved; temperature response sulfobetaines-adenine nano-particles, namely the thermo-sensitive polymer carrier is synthesized through a pocket copolymerization method, the process is simple, raw materials are cheap, harmful intermediate products cannot be generated, the thermo-sensitive polymer carrier can be assembled to amphiphilic drugs, stable drug nano ions are generated, the cytotoxicity of drug can be lowered, the stability of enzyme can be improved, and the antibacterial effect of drug is further greatly enhanced.

Description

technical field [0001] The invention belongs to the field of polymer materials and relates to a polymer carrier, in particular to a temperature-sensitive polymer carrier, a preparation method and an application thereof. Background technique [0002] In 1928, British bacteriologist Fleming first discovered the world's first antibiotic - penicillin. Its appearance ushered in a new era of using antibiotics to treat diseases, and the ability of human beings to resist bacterial infections was greatly enhanced. Antibiotics are a class of secondary metabolites produced by microorganisms or higher animals and plants in the course of life that have anti-pathogen or other activities, and chemical substances that can interfere with the development and function of other living cells. However, with the excessive use of antibiotics, the resistance of bacteria to antibiotics has increased, which greatly reduces its therapeutic effect on bacterial infections, and the emergence of "super bac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/38C08F220/34A61K47/32
Inventor 华道本董萍周媛何伟伟
Owner SUZHOU UNIV
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