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30 results about "Thermo sensitive polymer" patented technology
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Dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and preparation method thereof
InactiveCN102660841ARich sourcesLow priceNon-woven fabricsSpinning solutions preparationPolymer scienceSolvent
The invention relates to a dual-hydrophilic thermo-sensitive polymer / lactic acid polymer composite nanofiber felt and a preparation method thereof. The nanofiber felt comprises the following components: dual-hydrophilic thermo-sensitive polymer and lactic acid polymer with the mass ratio of 10:1. The preparation method comprises the following steps: (1) carrying out free radical polymerization reaction on glucaric acid divinyl ester and N-isopropyl acrylamide to obtain the dual-hydrophilic thermo-sensitive polymer; (2) dissolving the high polymer in a solvent, stirring for 1-4 hours, and carrying out ultrasonic degassing to obtain a spinning solution A; (3) dissolving the lactic acid polymer in the solvent, stirring for 1-8 hours, carrying out ultrasonic degassing to obtain a spinning solution B; and (4) mixing the spinning solution A with the spinning solution B, and carrying out electrostatic spinning to obtain the dual-hydrophilic thermo-sensitive polymer / lactic acid polymer composite nanofiber felt. According to the invention, the method is continuously feasible, the operation is simple and easy, industrialization is easy to realize, and the obtained nanofiber felt can be used for carrying medicines and control the release of the medicine; and the nanofiber felt can also be implanted into a release system and can be used in the fields of tissue engineering scaffold and the like.
Owner:DONGHUA UNIV
Method for preparing double hydrophilic thermo-sensitive polymer nano micelles
InactiveCN102659980AEasy to operateShort timeGenetic material ingredientsPharmaceutical non-active ingredientsHydrophilic monomerNanoreactor
The invention relates to a method for preparing double hydrophilic thermo-sensitive polymer nano micelles. The method comprises the following steps of: (1) preparing aliphatic diacid divinyl ester, dissolving the aliphatic diacid divinyl ester and glucose into an organic solvent, adding bacillus subtilis alkaline protease or lipase LipaseAY30 to synthesize a polymerizable glucose-containing hydrophilic monomer, dissolving the polymerizable glucose-containing hydrophilic monomer, an N-isopropyl acrylamide monomer and an initiator into an organic solvent, performing polymerization reaction to obtain a polymer, repeatedly precipitating, and drying the obtained precipitate in vacuum to obtain a full hydrophilic random copolymer; and (2) dissolving the full hydrophilic random copolymer into double distilled water, performing freeze drying after full dissolution and uniform dispersion, and thus obtaining the nano micelles. The method is simple, mild in reaction conditions, easy and convenient to operate and easy to industrialize; and the obtained double hydrophilic thermo-sensitive polymer nano micelles can be applied in the fields of medicament targeting delivery, gene therapy, crystal control growth regulators, nano reactors and the like.
Owner:DONGHUA UNIV
Thermo-sensitive type amphipathy polymer modified paper base filter membrane and preparation method thereof
ActiveCN107261868AHigh grafting rateIncreased sensitivitySemi-permeable membranesEthylenediamineFiber
The invention discloses a thermo-sensitive type amphipathy polymer modified paper base filter membrane. The preparation method of the thermo-sensitive type amphipathy polymer modified paper base filter membrane comprises the following steps that: firstly, taking ethanediamine and methyl acrylate as raw materials to synthesize a dendritic macromolecule of which the end group contains four amidogens; then, utilizing the amidogens to react with filter paper fiber surface hydroxyl to obtain a filter paper base membrane which loads the dendritic macromolecule; then, taking 2-mercaptopropionic acid as chain transfer agent to participate in the polymerization reaction of N-isopropyl acrylamide so as to prepare N-isopropyl acrylamide carboxylic acid derivatives; enabling the end carboxylic group of the N-isopropyl acrylamide carboxylic acid derivatives to react with the amidogen of the dendritic macromolecule under the function of dehydrating agent; introducing thermo-sensitive type polymer onto the surface of the paper base to obtain the thermo-sensitive type filter membrane. The aqueous solution of the thermo-sensitive polymer N-isopropyl acrylamide on the surface of the filter membrane has hydrophilic / lyophobic transformation near a temperature of 31-33 DEG C; under the irradiation of external environment, the effective separation of protein, oil and water phases and the like can be realized.
Owner:ANQING NORMAL UNIV
Four-branched thermo-sensitive polymer and preparation method thereof
The invention provides a thermo-sensitive polymer. The structural formula of the thermo-sensitive polymer is as shown in the specification. A preparation method of the thermo-sensitive polymer includes the steps: taking pentaerythritol as a core, reacting the pentaerythritol and acylating agents to obtain initiating agents, and performing atom transfer radical polymerization for the initiating agents and thermo-sensitive monomers to obtain active thermo-sensitive polymers with uniform chain length and controllable molecular weight; performing azidation for tail ends of the polymers to obtain the thermo-sensitive polymer with azido tail ends. Compared with the prior art, the polymer has the advantages of simplicity, convenience and easiness in implementation, branch number and branch length can be controlled, and the polymer is flexible and adjustable in structure, can be conveniently modified and has excellent thermo-sensitivity, use ranges close to environment temperature and excellent application prospects.
Owner:GUANGDONG UNIV OF TECH
Thermo-sensitive polymer as well as synthetic method and application thereof
InactiveCN108484824AEasy to prepareDifferent Temperature SensitivityPharmaceutical non-active ingredientsControlled releasePolymer science
The invention discloses a thermo-sensitive polymer as well as a synthetic method and application thereof. A structure of the thermo-sensitive polymer is as shown in formula I. The synthetic method comprises the following steps: adding an initiator, a monomer and a ligand into a solvent, deoxygenating, adding cuprous bromide, reacting for 0.5 to 5 hours, washing product precipitates for a pluralityof times, drying, and obtaining a copolymer; dissolving the copolymer in a N,N-dimethyl formamide solution; and adding imidazole, reacting for 24 to 48 hours, precipitating a product, washing for a plurality of times, drying, and obtaining the thermo-sensitive polymer. The thermo-sensitive polymer can have different thermo-sensitive characteristics by adjusting the composition of the copolymer; and by adjusting the polymer composition in a wider range, the turbidity point temperature of LCST or UCST can be changed, and the thermo-sensitive polymer can be applied to various fields such as biochemistry, medicine or food of drug controlled release, catalyst step-by-step release, cell embedding and the like.
Owner:SUZHOU UNIV OF SCI & TECH
Luminous microsphere and its production method and water dispersion system
ActiveCN1690163ABiocompatibleGood biocompatibilityLuminescent compositionsLuminous intensityBiocompatibility Testing
The invention provides a method for produing fluorescent microsphere, which contains: mixing thermo-sensitive polymer microspheres with water-soluble inorganic fluorescent nanometer particles with function group on the surface; evoking phase change of the composite; separating the phase-changed composite to prepare fluorescent microsphere. And it also provides the fluorescent microsphere and its water disperse system prepared by the method. The invention is of mild reaction condition, simple preparing process and convenient operation, which is suitable for scaled and commercial production, especially for preparing fluorescent marking microsphere for biomedicine check. The prepared fluorescent microsphere is in the nanometer dimensional range; grain size and appearance is homogeneous; luminous intensity is high; luminous purity is nice, dispersion is steady in water and have fine biocompatibility.
Owner:INST OF CHEM CHINESE ACAD OF SCI
Method for separating/gathering trace ciprofloxacin in food
InactiveCN103191581AAchieve secondary extractionImprove extraction efficiencyComponent separationLiquid solutions solvent extractionInorganic saltsSeparation technology
The invention relates to a method for separating / gathering trace ciprofloxacin in food, belonging to the field of environment analysis technologies. The method is a novel separation technology in which thermo-sensitive polymer EOPO (ethylene oxide and propylene oxide copolymer) and salt are mixed, the property that the affinity of a surface active agent and water is changed under a temperature change condition is utilized, and an aqueous two-phase system is formed with the combination of inorganic salt to perform extraction separation. The novel separation system has the advantage of aqueous two-phase extraction, and can realize secondary extraction due to the temperature separation property of the thermo-sensitive polymer, so that the extraction efficiency is higher than that of one-time extraction, and besides, the recovery of phase components enables the experiment cost to be reduced.
Owner:JIANGSU UNIV
Separating and purifying method for Chinese wolfberry polyose
The invention belongs to the technical field of biomacromolecule separation and purification, and particularly relates to a separating and purifying method for Chinese wolfberry polyose. According to the method provided by the invention, novel thermo-sensitive periodic copolymers, namely polyethylene oxide-polypropylene oxide-polyethylene oxide and inorganic salt, are used for forming a two-phase aqueous system, and small molecular weight impurities such as protein, coloring matters and the like in Chinese wolfberry polyose are removed. Inorganic salt in a lower phase is removed according to a dialysis method, and ethyl alcohol is deposited to obtain a polyose finished product; in virtue of a temperature response behavior of a thermo-sensitive polymer, and through multi-step comprehensive operations such as protein precipitation through temperature reduction, PH value adjustment, heating for phase separation and the like, the thermo-sensitive polymer in an upper phase can be recovered successfully. The invention provides a novel protein removing method which is efficient, green and low in cost, the thermo-sensitive periodic copolymer is effectively recovered and reused, the defects of high price and difficult recovering of a polymer formed through a traditional polymer aqueous two phase method can be overcome, material consumption and cost are reduced greatly, and the method can be applied to industrialized production in large scale.
Owner:JIANGSU UNIV
Use of thermo-sensitive gel for controlled delivery of alk-5 inhibitors to the eye and related methods
InactiveUS20140271903A1Extended maintenance periodOrganic active ingredientsOintment deliveryGlaucomaFibrosis
The present invention relates to a methods for extending the period of filtering bleb survival and / or providing for long term bleb survival following Glaucoma Filtration Surgery by delivering an ALK-5 inhibitor to a wound area (the surgical site) of a patient's eye. More particularly, the present invention relates to a method for the controlled delivery of an ALK-5 inhibitor to patient's eye using a thermo-sensitive polymer formulation, wherein the ALK-5 inhibitor is first contained in the polymer formulation at a temperature sufficient to maintain the formulation as a liquid and then applied to the eye wound opening, wherein the formulation turns to a gel. The use of the thermo-sensitive gel with ALK-5 inhibitor contained therein, provides for longer term bleb survival following Glaucoma Filtration Surgery (GFS) on a patient's eye. Thus, the present invention is particularly effective in inhibiting ocular fibrotic wound response following GFS.
Owner:NORTHEAST OHIO MEDICAL UNIV
Intelligent tracer agent, preparation method and application thereof and oil field tracing analysis method
The invention provides an intelligent tracer agent, a preparation method and application thereof and an oil field tracing analysis method and belongs to the technical field of oil reservoir inter-welltracing. The tracer agent comprises a thermo-sensitive polymer and salt. The salt comprises metallic compounds of bivalency and above, third, fourth and fifth main group elements, salt of a lanthanide series metal element, vitamin B2, sodium benzoate or halogenation sodium benzoate. The tracer agent can be applied to oil well tracing measuring analysis to obtain a fluid and reservoir stratum information between a water injection well and an oil producing well (inter-well) and all parameters of crude oil. The preparation method of the intelligent tracer agent is simple. By utilizing the intelligent tracer agent to conduct tracing analysis on the oil well, all parameters of the underground oil well can be conveniently and accurately known, and accurate information is provided for oil well mining.
Owner:盘锦鸿鼎油气技术服务有限公司
Thermo-sensitive ionic imprinting polymer for separating high rhenium acid radical ions and preparation method and application of thermo-sensitive ionic imprinting polymer
InactiveCN110343222AEasy to prepareThe recycling process is simple and controllableOther chemical processesRheniumPolymer science
The invention discloses a thermo-sensitive ionic imprinting polymer for separating high rhenium acid radical ions and a preparation method and application of the thermo-sensitive ionic imprinting polymer and belongs to the field of wet-method metallurgy. The preparation method comprises the following steps: preparing a thermo-sensitive polymer N,N-diethyl acrylamide (PDEA) through a reversible addition-fragmentation transfer (RAFT) polymerization reaction, and introducing the thermo-sensitive polymer into a synthesis process for separating high rhenium acid radical ionic imprinting polymer (ReO4<->-IIP) for secondary polymerization, so as to obtain an imprinting polymer which has a thermo-sensitive block and is used for separating high rhenium acid radical ions. With the polymer as an adsorption carrier, precise separation on the rhenium (Re) element in a rhenium-containing solution is achieved, and the recycling efficiency of Re is greatly improved. The ionic imprinting polymer with the thermo-sensitive block, which is disclosed by the invention, is high in carrier selectivity, large in adsorption capacity, high in desorption rate and high in repeated use rate, and defects of a conventional separation material in the field of wet-method recycling of alloys can be made up.
Owner:LANZHOU UNIVERSITY OF TECHNOLOGY +1
Thermo-sensitive polymer carrier and preparation method and application thereof
InactiveCN105175625ALow cytotoxicityImprove antibacterial propertiesPharmaceutical non-active ingredientsChemical structureTemperature response
The invention relates to a thermo-sensitive polymer carrier and a preparation method and application thereof. The thermo-sensitive polymer carrier is formed by copolymerization of a monomer A and a monomer B under the action of initiator. Please see the chemical structural formula of the monomer A in specification, and please see the chemical structural formula of the monomer B in specification. Amphiphilic ionic functional groups are introduced into a molecular structure of the thermo-sensitive polymer carrier, the pollution-free nature of the surfaces of nano-particles is created, high protein adsorption resistance property is achieved, the property of thermo-sensitive response is achieved, and the functions of low-temperature packing and high-temperature medicine fast releasing are achieved; temperature response sulfobetaines-adenine nano-particles, namely the thermo-sensitive polymer carrier is synthesized through a pocket copolymerization method, the process is simple, raw materials are cheap, harmful intermediate products cannot be generated, the thermo-sensitive polymer carrier can be assembled to amphiphilic drugs, stable drug nano ions are generated, the cytotoxicity of drug can be lowered, the stability of enzyme can be improved, and the antibacterial effect of drug is further greatly enhanced.
Owner:SUZHOU UNIV
Thermo-sensitive poly(proline-creatine) material and preparation method thereof
InactiveCN106432713AObvious temperature response characteristicsGood biocompatibilityPolymer scienceBiocompatibility Testing
The invention discloses a thermo-sensitive poly(proline-creatine) material, belongs to the field of thermo-sensitive polymers in smart materials and relates to a polymer material with the advantages of high biocompatibility, biodegradability and thermo-sensitivity. The thermo-sensitive poly(proline-creatine) material is composed of constitutional units shown in a formula (I), is a random copolymer and has a molecular weight of (0.8-1.6)*10<4>, wherein the structural formula is as shown in the specification, and a ratio of n to m is equal to 1:(0.09-0.76). The invention also discloses a method for preparing the thermo-sensitive poly(proline-creatine) material. The polymer material prepared by the invention has the thermo-sensitivity and excellent biocompatibility and biodegradability.
Owner:HEBEI UNIVERSITY
Luminous microsphere and its production method and water dispersion system
ActiveCN1318539CBiocompatibleGood biocompatibilityLuminescent compositionsLuminous intensityBiocompatibility Testing
The invention provides a method for produing fluorescent microsphere, which contains: mixing thermo-sensitive polymer microspheres with water-soluble inorganic fluorescent nanometer particles with function group on the surface; evoking phase change of the composite; separating the phase-changed composite to prepare fluorescent microsphere. And it also provides the fluorescent microsphere and its water disperse system prepared by the method. The invention is of mild reaction condition, simple preparing process and convenient operation, which is suitable for scaled and commercial production, especially for preparing fluorescent marking microsphere for biomedicine check. The prepared fluorescent microsphere is in the nanometer dimensional range; grain size and appearance is homogeneous; luminous intensity is high; luminous purity is nice, dispersion is steady in water and have fine biocompatibility.
Owner:INST OF CHEM CHINESE ACAD OF SCI
Synthetic method for amphiphilic polyethylene glycol (PEG)-polycyclic lactone copolymer including multiple bromine functional groups and thermo-sensitive polymer preparing method
The invention relates to a synthetic method for an amphiphilic polyethylene glycol (PEG)-polycyclic lactone copolymer including multiple bromine functional groups and a thermo-sensitive polymer preparing method. Double-terminal hydroxyl polyethylene glycol is used as an initiator, alpha-bromine-gamma-butyrolactone and epsilon-caprolactone are used as monomers, stannous octoate is used as a catalyst, the copolymer with a main chain including the multiple bromine functional groups is prepared at one step through the controllable ring opening polymerization (ROP) method, and the synthetic method is convenient, fast and controllable. The bromine functional groups on the main chain of the copolymer are used as the initiator, an atom transfer radical polymerization (ATRP) method is adopted, N-isopropylacrylamide (NIPAM) is used as the monomer, CuBr / PMDETA is used as the catalytic system, and accordingly a PEG-P(CL-r-BL)-g-PNIPAM thermo-sensitive polymer is prepared. The low critical consolute temperature (LCST) is adjusted by adjusting the proportion of hydrophilicity and hydrophobicity chain segments in the copolymer, so that the temperature is close to the temperature of a human body. The synthetic method and the preparing method have a good application prospect in the field of temperature response drug controlled release.
Owner:SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
Adhesive cartilage implant
InactiveUS20100166822A1Reduce the temperatureBiocideMammal material medical ingredientsCulture cellBone implant
A method of producing a cartilage implant which may include coating a substrate with a thermo-sensitive polymer, seeding the polymer with a cell suspension comprising cells that may differentiate into chrondocyte-like cells, wherein the seeding may be conducted at a first temperature, culturing the cell suspension at an increased temperature, whereby cells in the suspension may adhere to the polymer and differentiate into chrondrocyte-like cells, which may form a cartilagenous implant, and decreasing the temperature of the polymer which may allow detachment of the implant from the polymer. The present invention may also include an implant based on this method. The invention may further include a cartilage implant for use in a patient in need thereof, which may include a random three-dimensional configuration of differentiated cells, which may have a natural adhesion surface on at least a portion of the outer surface of the three-dimensional configuration.
Owner:HOWMEDICA OSTEONICS CORP
Method for preparing thermo-sensitive polymer PNIPAM film through plasma-induced solution polymerization
The invention discloses a method for preparing thermo-sensitive polymer PNIPAM film through plasma-induced solution polymerization, relates to a method for preparing the thermo-sensitive polymer PNIPAM film and aims at solving the problems of complex process, proneness to causing damage to shape and unstable chemical property of existing PNIPAM film synthesis methods. The method includes: step 1, dissolving N-isopropyl acrylamide crystal in ultrapure water, and adding N, N-methylene bisacrylamide; step 2, spreading a solution prepared in the step 1 on the surface of a glass substrate, putting the glass substrate in a quartz reaction kettle, sealing, and feeding argon; step 3, putting the quartz reaction kettle between two poles of a plasma generator for treatment to obtain a thin film, and cleaning and drying the thin film to complete preparation. Plasma-induced solution polymerization is adopted for film forming, so that the method is simple in process and few in step; film forming is independent from surface property of the substrate; the shape of the film is less prone to being damaged, and the film is stable in chemical property; the film is unitary in ingredient, biologically-nontoxic, conducive to modification and modifiable in structure and has great potential application prospect in many fields.
Owner:黑龙江省工研院资产经营管理有限公司
Thermo-sensitive polymer-based hollow fiber and hollow microsphere as well as preparation method and application thereof
ActiveCN108250354AAvoid missingTo achieve the goal of zero releaseHollow filament manufacturePharmaceutical non-active ingredientsFiberMicrosphere
The invention belongs to the field of macromolecules and relates to a thermo-sensitive polymer-based hollow fiber and hollow microspheres as well as a preparation method and application thereof. The preparation method of the thermo-sensitive polymer-based hollow fiber and or hollow microspheres comprises the following steps: preparing a homogeneous solution as an external spinning liquid from a water-soluble poly N-isopropyl acrylamide polymer, preparing a homogeneous solution as an internal spinning liquid from an anti-cancer medicine, and preparing the thermo-sensitive polymer-based hollow fiber and or hollow microspheres with the thermo-sensitive polymer as a shell layer and the anti-cancer medicine as a core layer from the external spinning liquid and the internal spinning liquid by using a coaxial electrostatic spinning method. The thermo-sensitive polymer-based hollow fiber and or hollow microspheres provided by the invention can be used as a cancer medicine carrier, medicines can be completely wrapped by the carrier, and the purpose of zero medicine release in transportation can be achieved; when reaching an affected part, medicines inside cavities can be released by virtueof volume shrinkage of the thermo-sensitive material at a high temperature, then a targeting release effect can be achieved, and the defects of medicine chemotherapy treatment on cancer can be overcome.
Owner:SICHUAN UNIV
Kieselguhr-based composite material and preparation method thereof
InactiveCN105777994AIt has dual functions of temperature regulation and humidity regulationGood temperature and humidity regulationDesorptionMoisture
The invention discloses a kieselguhr-based composite material which is characterized by being prepared from the following components: crylic acid, methylcellulose, dodecanol, lauric acid, kieselguhr, peroxosulfuric acid, N,N'-methylene bisacrylamide. According to the kieselguhr-based composite material, the kieselguhr with high moisture releasability, an organic macromolecular material with high hygroscopicity and phase change materials such as dodecanol, lauric acid and thermo-sensitive polymer methylcellulose are combined and matched to prepare a novel composite material with two functions of adjusting the temperature and the humidity. The temperature and humidity adjustment effect of the composite material is good, and the maximum hydroscopicity and moisture desorption ratios are respectively 128 percent and 85 percent.
Owner:张学健
Preparation method and application of hydrogel based on rhabdovirus
InactiveCN103319732AGood biocompatibilityQuick changePeptide/protein ingredientsPharmaceutical non-active ingredientsPolymer modifiedChemical reaction
The invention discloses a preparation method of hydrogel based on rhabdovirus. The virus hydrogel is composed of macromolecule-modified rod-shaped composite virus particles, and the rhabdovirus is fd bacteriophage. The preparation method comprises the following steps of: preparing a thermo-sensitive polymer solution; preparing a virus solution of the fd bacteriophage; dropwise adding the thermo-sensitive polymer solution into the virus solution to obtain thermo-sensitive macromolecule-modified composite virus particles; and dissolving the polymer-modified virus particles in a phosphoric acid buffer solution to obtain a solution, and heating the solution to a temperature higher than the gelation transformation temperature to obtain the hydrogel based on rhabdovirus. The preparation method disclosed by the invention has the advantages that the virus hydrogel has good biocompatibility and can generate quick and reversible sol-gel transformation at a specific gelation temperature point; massive chemical functional groups on the surface of the rhabdovirus can be bound with specific-function groups as chemical reaction hot spots; and after gel formation, the active groups on the skeleton surface are still available, and the hydrogel can be used as an insulin sustained-release intelligent material.
Owner:NANKAI UNIV
Titanium dioxide/thermo-sensitive polymer hybrid material as well as preparation method and application thereof
InactiveCN109306060AKeep aliveHigh synthesis rateWater/sewage treatment by irradiationWater contaminantsPolymer sciencePhotocatalytic degradation
The invention discloses a titanium dioxide / thermo-sensitive polymer hybrid material as well as a preparation method and application thereof. The hybrid material is characterized in that nano-TiO2 is taken as a core, and a thermo-sensitive polymer, namely, poly-(glycol)ester ethylether-random-(glycol)methyl ether acrylic ester or poly-(glycol)ester ethylether-segmented-(glycol)methyl ether acrylicester is grafted onto the surface. Based on an SET-LRP (Single Electron Transfer-Living Radical Polymerization) method, a nitrogen-containing ligand which has high catalytic activity and tends to cause the disproportionation of copper is selected in the presence of a catechol initiator, so that strong complexing of a copper halide is realized, and the interference with a metal catalyst caused by acatechol group is realized in order to prepare a series of water-soluble polymers. The hybrid material is stable in structure, the low critical dissolving temperature of the water-soluble polymer isregulated and controlled by controlling the molecular weight of the polymer, uniform dispersion as well as self-fluctuation and recovery of TiO2 nanoparticles in water can be realized through a temperature switch, and sunlight photocatalytic degradation of target pollutants is realized. The hybrid material is suitable for sewage of different temperatures.
Owner:NANJING UNIV OF SCI & TECH
Synthesis method of amphiphilic polyethylene glycol-polycyclic lactone copolymer containing multiple bromine functional groups and preparation method of thermosensitive polymer
The invention relates to a synthetic method for an amphiphilic polyethylene glycol (PEG)-polycyclic lactone copolymer including multiple bromine functional groups and a thermo-sensitive polymer preparing method. Double-terminal hydroxyl polyethylene glycol is used as an initiator, alpha-bromine-gamma-butyrolactone and epsilon-caprolactone are used as monomers, stannous octoate is used as a catalyst, the copolymer with a main chain including the multiple bromine functional groups is prepared at one step through the controllable ring opening polymerization (ROP) method, and the synthetic method is convenient, fast and controllable. The bromine functional groups on the main chain of the copolymer are used as the initiator, an atom transfer radical polymerization (ATRP) method is adopted, N-isopropylacrylamide (NIPAM) is used as the monomer, CuBr / PMDETA is used as the catalytic system, and accordingly a PEG-P(CL-r-BL)-g-PNIPAM thermo-sensitive polymer is prepared. The low critical consolute temperature (LCST) is adjusted by adjusting the proportion of hydrophilicity and hydrophobicity chain segments in the copolymer, so that the temperature is close to the temperature of a human body. The synthetic method and the preparing method have a good application prospect in the field of temperature response drug controlled release.
Owner:SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
Method for preparing double hydrophilic thermo-sensitive polymer nano micelles
InactiveCN102659980BEasy to operateShort timeGenetic material ingredientsPharmaceutical non-active ingredientsHydrophilic monomerNanoreactor
Owner:DONGHUA UNIV
Thermosensitive poly(proline-sarcosine) material and preparation method thereof
InactiveCN106432713BObvious temperature response characteristicsGood biocompatibilityPolymer scienceBiocompatibility Testing
The invention discloses a thermo-sensitive poly(proline-creatine) material, belongs to the field of thermo-sensitive polymers in smart materials and relates to a polymer material with the advantages of high biocompatibility, biodegradability and thermo-sensitivity. The thermo-sensitive poly(proline-creatine) material is composed of constitutional units shown in a formula (I), is a random copolymer and has a molecular weight of (0.8-1.6)*10<4>, wherein the structural formula is as shown in the specification, and a ratio of n to m is equal to 1:(0.09-0.76). The invention also discloses a method for preparing the thermo-sensitive poly(proline-creatine) material. The polymer material prepared by the invention has the thermo-sensitivity and excellent biocompatibility and biodegradability.
Owner:HEBEI UNIVERSITY
Preparation method of a microchip linear negative temperature coefficient thermistor
ActiveCN106653260BStabilize the NTC effectGood dispersionResistor chip manufactureNegative temperatureThermistor
The invention discloses a production method of a microchip linear negative temperature coefficient thermistor. The production method includes: producing a thermo-sensitive polymer composite material similar to slurry, producing the evenly-stirred polymer composite material into a tape casting material, performing tape casting, gold foil layer coating, isostatic pressing, hot pressing and ultraviolet radiation crosslinking to produce the polymer-composite-material substrate of the thermistor, and precisely cutting the polymer-composite-material substrate according to product technical requirements to obtain the microchip linear negative temperature coefficient thermistor. The production method has the advantages that the produced microchip linear negative temperature coefficient (NTC) thermistor is high in resistance precision, adjustable in resistance, stable in resistance and TCR (temperature coefficient of resistance), reliable in product performance, and the like; the production method has important practical value to the industrial production of the microchip linear negative temperature coefficient thermistor.
Owner:CHINA ZHENHUA GRP YUNKE ELECTRONICS
A kind of separation and purification method of Lycium barbarum polysaccharide
The invention belongs to the technical field of biomacromolecule separation and purification, and particularly relates to a separating and purifying method for Chinese wolfberry polyose. According to the method provided by the invention, novel thermo-sensitive periodic copolymers, namely polyethylene oxide-polypropylene oxide-polyethylene oxide and inorganic salt, are used for forming a two-phase aqueous system, and small molecular weight impurities such as protein, coloring matters and the like in Chinese wolfberry polyose are removed. Inorganic salt in a lower phase is removed according to a dialysis method, and ethyl alcohol is deposited to obtain a polyose finished product; in virtue of a temperature response behavior of a thermo-sensitive polymer, and through multi-step comprehensive operations such as protein precipitation through temperature reduction, PH value adjustment, heating for phase separation and the like, the thermo-sensitive polymer in an upper phase can be recovered successfully. The invention provides a novel protein removing method which is efficient, green and low in cost, the thermo-sensitive periodic copolymer is effectively recovered and reused, the defects of high price and difficult recovering of a polymer formed through a traditional polymer aqueous two phase method can be overcome, material consumption and cost are reduced greatly, and the method can be applied to industrialized production in large scale.
Owner:JIANGSU UNIV
Production method of microchip linear negative temperature coefficient thermistor
ActiveCN106653260AStabilize the NTC effectGood dispersionResistor chip manufactureNegative temperatureThermistor
The invention discloses a production method of a microchip linear negative temperature coefficient thermistor. The production method includes: producing a thermo-sensitive polymer composite material similar to slurry, producing the evenly-stirred polymer composite material into a tape casting material, performing tape casting, gold foil layer coating, isostatic pressing, hot pressing and ultraviolet radiation crosslinking to produce the polymer-composite-material substrate of the thermistor, and precisely cutting the polymer-composite-material substrate according to product technical requirements to obtain the microchip linear negative temperature coefficient thermistor. The production method has the advantages that the produced microchip linear negative temperature coefficient (NTC) thermistor is high in resistance precision, adjustable in resistance, stable in resistance and TCR (temperature coefficient of resistance), reliable in product performance, and the like; the production method has important practical value to the industrial production of the microchip linear negative temperature coefficient thermistor.
Owner:CHINA ZHENHUA GRP YUNKE ELECTRONICS
A method for preparing thermosensitive polymer pnipam film by plasma-induced solution polymerization
The invention discloses a method for preparing thermo-sensitive polymer PNIPAM film through plasma-induced solution polymerization, relates to a method for preparing the thermo-sensitive polymer PNIPAM film and aims at solving the problems of complex process, proneness to causing damage to shape and unstable chemical property of existing PNIPAM film synthesis methods. The method includes: step 1, dissolving N-isopropyl acrylamide crystal in ultrapure water, and adding N, N-methylene bisacrylamide; step 2, spreading a solution prepared in the step 1 on the surface of a glass substrate, putting the glass substrate in a quartz reaction kettle, sealing, and feeding argon; step 3, putting the quartz reaction kettle between two poles of a plasma generator for treatment to obtain a thin film, and cleaning and drying the thin film to complete preparation. Plasma-induced solution polymerization is adopted for film forming, so that the method is simple in process and few in step; film forming is independent from surface property of the substrate; the shape of the film is less prone to being damaged, and the film is stable in chemical property; the film is unitary in ingredient, biologically-nontoxic, conducive to modification and modifiable in structure and has great potential application prospect in many fields.
Owner:黑龙江省工研院资产经营管理有限公司
Method for separating/gathering trace ciprofloxacin in food
InactiveCN103191581BEasy to handleHigh enrichment factorComponent separationLiquid solutions solvent extractionInorganic saltsSeparation technology
The invention relates to a method for separating / gathering trace ciprofloxacin in food, belonging to the field of environment analysis technologies. The method is a novel separation technology in which thermo-sensitive polymer EOPO (ethylene oxide and propylene oxide copolymer) and salt are mixed, the property that the affinity of a surface active agent and water is changed under a temperature change condition is utilized, and an aqueous two-phase system is formed with the combination of inorganic salt to perform extraction separation. The novel separation system has the advantage of aqueous two-phase extraction, and can realize secondary extraction due to the temperature separation property of the thermo-sensitive polymer, so that the extraction efficiency is higher than that of one-time extraction, and besides, the recovery of phase components enables the experiment cost to be reduced.
Owner:JIANGSU UNIV
Dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and preparation method thereof
InactiveCN102660841BRich sourcesLow priceNon-woven fabricsSpinning solutions preparationPolymer scienceSolvent
The invention relates to a dual-hydrophilic thermo-sensitive polymer / lactic acid polymer composite nanofiber felt and a preparation method thereof. The nanofiber felt comprises the following components: dual-hydrophilic thermo-sensitive polymer and lactic acid polymer with the mass ratio of 10:1. The preparation method comprises the following steps: (1) carrying out free radical polymerization reaction on glucaric acid divinyl ester and N-isopropyl acrylamide to obtain the dual-hydrophilic thermo-sensitive polymer; (2) dissolving the high polymer in a solvent, stirring for 1-4 hours, and carrying out ultrasonic degassing to obtain a spinning solution A; (3) dissolving the lactic acid polymer in the solvent, stirring for 1-8 hours, carrying out ultrasonic degassing to obtain a spinning solution B; and (4) mixing the spinning solution A with the spinning solution B, and carrying out electrostatic spinning to obtain the dual-hydrophilic thermo-sensitive polymer / lactic acid polymer composite nanofiber felt. According to the invention, the method is continuously feasible, the operation is simple and easy, industrialization is easy to realize, and the obtained nanofiber felt can be used for carrying medicines and control the release of the medicine; and the nanofiber felt can also be implanted into a release system and can be used in the fields of tissue engineering scaffold and the like.
Owner:DONGHUA UNIV
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