30 results about "Thermo sensitive polymer" patented technology

The invention relates to a dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and a preparation method thereof. The nanofiber felt comprises the following components: dual-hydrophilic thermo-sensitive polymer and lactic acid polymer with the mass ratio of 10:1. The preparation method comprises the following steps: (1) carrying out free radical polymerization reaction on glucaric acid divinyl ester and N-isopropyl acrylamide to obtain the dual-hydrophilic thermo-sensitive polymer; (2) dissolving the high polymer in a solvent, stirring for 1-4 hours, and carrying out ultrasonic degassing to obtain a spinning solution A; (3) dissolving the lactic acid polymer in the solvent, stirring for 1-8 hours, carrying out ultrasonic degassing to obtain a spinning solution B; and (4) mixing the spinning solution A with the spinning solution B, and carrying out electrostatic spinning to obtain the dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt. According to the invention, the method is continuously feasible, the operation is simple and easy, industrialization is easy to realize, and the obtained nanofiber felt can be used for carrying medicines and control the release of the medicine; and the nanofiber felt can also be implanted into a release system and can be used in the fields of tissue engineering scaffold and the like.

The invention relates to a method for preparing double hydrophilic thermo-sensitive polymer nano micelles. The method comprises the following steps of: (1) preparing aliphatic diacid divinyl ester, dissolving the aliphatic diacid divinyl ester and glucose into an organic solvent, adding bacillus subtilis alkaline protease or lipase LipaseAY30 to synthesize a polymerizable glucose-containing hydrophilic monomer, dissolving the polymerizable glucose-containing hydrophilic monomer, an N-isopropyl acrylamide monomer and an initiator into an organic solvent, performing polymerization reaction to obtain a polymer, repeatedly precipitating, and drying the obtained precipitate in vacuum to obtain a full hydrophilic random copolymer; and (2) dissolving the full hydrophilic random copolymer into double distilled water, performing freeze drying after full dissolution and uniform dispersion, and thus obtaining the nano micelles. The method is simple, mild in reaction conditions, easy and convenient to operate and easy to industrialize; and the obtained double hydrophilic thermo-sensitive polymer nano micelles can be applied in the fields of medicament targeting delivery, gene therapy, crystal control growth regulators, nano reactors and the like.

The invention discloses a thermo-sensitive type amphipathy polymer modified paper base filter membrane. The preparation method of the thermo-sensitive type amphipathy polymer modified paper base filter membrane comprises the following steps that: firstly, taking ethanediamine and methyl acrylate as raw materials to synthesize a dendritic macromolecule of which the end group contains four amidogens; then, utilizing the amidogens to react with filter paper fiber surface hydroxyl to obtain a filter paper base membrane which loads the dendritic macromolecule; then, taking 2-mercaptopropionic acid as chain transfer agent to participate in the polymerization reaction of N-isopropyl acrylamide so as to prepare N-isopropyl acrylamide carboxylic acid derivatives; enabling the end carboxylic group of the N-isopropyl acrylamide carboxylic acid derivatives to react with the amidogen of the dendritic macromolecule under the function of dehydrating agent; introducing thermo-sensitive type polymer onto the surface of the paper base to obtain the thermo-sensitive type filter membrane. The aqueous solution of the thermo-sensitive polymer N-isopropyl acrylamide on the surface of the filter membrane has hydrophilic/lyophobic transformation near a temperature of 31-33 DEG C; under the irradiation of external environment, the effective separation of protein, oil and water phases and the like can be realized.

The invention relates to a method for separating/gathering trace ciprofloxacin in food, belonging to the field of environment analysis technologies. The method is a novel separation technology in which thermo-sensitive polymer EOPO (ethylene oxide and propylene oxide copolymer) and salt are mixed, the property that the affinity of a surface active agent and water is changed under a temperature change condition is utilized, and an aqueous two-phase system is formed with the combination of inorganic salt to perform extraction separation. The novel separation system has the advantage of aqueous two-phase extraction, and can realize secondary extraction due to the temperature separation property of the thermo-sensitive polymer, so that the extraction efficiency is higher than that of one-time extraction, and besides, the recovery of phase components enables the experiment cost to be reduced.

The invention belongs to the technical field of biomacromolecule separation and purification, and particularly relates to a separating and purifying method for Chinese wolfberry polyose. According to the method provided by the invention, novel thermo-sensitive periodic copolymers, namely polyethylene oxide-polypropylene oxide-polyethylene oxide and inorganic salt, are used for forming a two-phase aqueous system, and small molecular weight impurities such as protein, coloring matters and the like in Chinese wolfberry polyose are removed. Inorganic salt in a lower phase is removed according to a dialysis method, and ethyl alcohol is deposited to obtain a polyose finished product; in virtue of a temperature response behavior of a thermo-sensitive polymer, and through multi-step comprehensive operations such as protein precipitation through temperature reduction, PH value adjustment, heating for phase separation and the like, the thermo-sensitive polymer in an upper phase can be recovered successfully. The invention provides a novel protein removing method which is efficient, green and low in cost, the thermo-sensitive periodic copolymer is effectively recovered and reused, the defects of high price and difficult recovering of a polymer formed through a traditional polymer aqueous two phase method can be overcome, material consumption and cost are reduced greatly, and the method can be applied to industrialized production in large scale.

The present invention relates to a methods for extending the period of filtering bleb survival and/or providing for long term bleb survival following Glaucoma Filtration Surgery by delivering an ALK-5 inhibitor to a wound area (the surgical site) of a patient's eye. More particularly, the present invention relates to a method for the controlled delivery of an ALK-5 inhibitor to patient's eye using a thermo-sensitive polymer formulation, wherein the ALK-5 inhibitor is first contained in the polymer formulation at a temperature sufficient to maintain the formulation as a liquid and then applied to the eye wound opening, wherein the formulation turns to a gel. The use of the thermo-sensitive gel with ALK-5 inhibitor contained therein, provides for longer term bleb survival following Glaucoma Filtration Surgery (GFS) on a patient's eye. Thus, the present invention is particularly effective in inhibiting ocular fibrotic wound response following GFS.

The invention discloses a thermo-sensitive ionic imprinting polymer for separating high rhenium acid radical ions and a preparation method and application of the thermo-sensitive ionic imprinting polymer and belongs to the field of wet-method metallurgy. The preparation method comprises the following steps: preparing a thermo-sensitive polymer N,N-diethyl acrylamide (PDEA) through a reversible addition-fragmentation transfer (RAFT) polymerization reaction, and introducing the thermo-sensitive polymer into a synthesis process for separating high rhenium acid radical ionic imprinting polymer (ReO4<->-IIP) for secondary polymerization, so as to obtain an imprinting polymer which has a thermo-sensitive block and is used for separating high rhenium acid radical ions. With the polymer as an adsorption carrier, precise separation on the rhenium (Re) element in a rhenium-containing solution is achieved, and the recycling efficiency of Re is greatly improved. The ionic imprinting polymer with the thermo-sensitive block, which is disclosed by the invention, is high in carrier selectivity, large in adsorption capacity, high in desorption rate and high in repeated use rate, and defects of a conventional separation material in the field of wet-method recycling of alloys can be made up.

The invention relates to a thermo-sensitive polymer carrier and a preparation method and application thereof. The thermo-sensitive polymer carrier is formed by copolymerization of a monomer A and a monomer B under the action of initiator. Please see the chemical structural formula of the monomer A in specification, and please see the chemical structural formula of the monomer B in specification. Amphiphilic ionic functional groups are introduced into a molecular structure of the thermo-sensitive polymer carrier, the pollution-free nature of the surfaces of nano-particles is created, high protein adsorption resistance property is achieved, the property of thermo-sensitive response is achieved, and the functions of low-temperature packing and high-temperature medicine fast releasing are achieved; temperature response sulfobetaines-adenine nano-particles, namely the thermo-sensitive polymer carrier is synthesized through a pocket copolymerization method, the process is simple, raw materials are cheap, harmful intermediate products cannot be generated, the thermo-sensitive polymer carrier can be assembled to amphiphilic drugs, stable drug nano ions are generated, the cytotoxicity of drug can be lowered, the stability of enzyme can be improved, and the antibacterial effect of drug is further greatly enhanced.

The invention relates to a synthetic method for an amphiphilic polyethylene glycol (PEG)-polycyclic lactone copolymer including multiple bromine functional groups and a thermo-sensitive polymer preparing method. Double-terminal hydroxyl polyethylene glycol is used as an initiator, alpha-bromine-gamma-butyrolactone and epsilon-caprolactone are used as monomers, stannous octoate is used as a catalyst, the copolymer with a main chain including the multiple bromine functional groups is prepared at one step through the controllable ring opening polymerization (ROP) method, and the synthetic method is convenient, fast and controllable. The bromine functional groups on the main chain of the copolymer are used as the initiator, an atom transfer radical polymerization (ATRP) method is adopted, N-isopropylacrylamide (NIPAM) is used as the monomer, CuBr/PMDETA is used as the catalytic system, and accordingly a PEG-P(CL-r-BL)-g-PNIPAM thermo-sensitive polymer is prepared. The low critical consolute temperature (LCST) is adjusted by adjusting the proportion of hydrophilicity and hydrophobicity chain segments in the copolymer, so that the temperature is close to the temperature of a human body. The synthetic method and the preparing method have a good application prospect in the field of temperature response drug controlled release.

A method of producing a cartilage implant which may include coating a substrate with a thermo-sensitive polymer, seeding the polymer with a cell suspension comprising cells that may differentiate into chrondocyte-like cells, wherein the seeding may be conducted at a first temperature, culturing the cell suspension at an increased temperature, whereby cells in the suspension may adhere to the polymer and differentiate into chrondrocyte-like cells, which may form a cartilagenous implant, and decreasing the temperature of the polymer which may allow detachment of the implant from the polymer. The present invention may also include an implant based on this method. The invention may further include a cartilage implant for use in a patient in need thereof, which may include a random three-dimensional configuration of differentiated cells, which may have a natural adhesion surface on at least a portion of the outer surface of the three-dimensional configuration.

The invention discloses a method for preparing thermo-sensitive polymer PNIPAM film through plasma-induced solution polymerization, relates to a method for preparing the thermo-sensitive polymer PNIPAM film and aims at solving the problems of complex process, proneness to causing damage to shape and unstable chemical property of existing PNIPAM film synthesis methods. The method includes: step 1, dissolving N-isopropyl acrylamide crystal in ultrapure water, and adding N, N-methylene bisacrylamide; step 2, spreading a solution prepared in the step 1 on the surface of a glass substrate, putting the glass substrate in a quartz reaction kettle, sealing, and feeding argon; step 3, putting the quartz reaction kettle between two poles of a plasma generator for treatment to obtain a thin film, and cleaning and drying the thin film to complete preparation. Plasma-induced solution polymerization is adopted for film forming, so that the method is simple in process and few in step; film forming is independent from surface property of the substrate; the shape of the film is less prone to being damaged, and the film is stable in chemical property; the film is unitary in ingredient, biologically-nontoxic, conducive to modification and modifiable in structure and has great potential application prospect in many fields.

The invention discloses a kieselguhr-based composite material which is characterized by being prepared from the following components: crylic acid, methylcellulose, dodecanol, lauric acid, kieselguhr, peroxosulfuric acid, N,N'-methylene bisacrylamide. According to the kieselguhr-based composite material, the kieselguhr with high moisture releasability, an organic macromolecular material with high hygroscopicity and phase change materials such as dodecanol, lauric acid and thermo-sensitive polymer methylcellulose are combined and matched to prepare a novel composite material with two functions of adjusting the temperature and the humidity. The temperature and humidity adjustment effect of the composite material is good, and the maximum hydroscopicity and moisture desorption ratios are respectively 128 percent and 85 percent.

The invention discloses a preparation method of hydrogel based on rhabdovirus. The virus hydrogel is composed of macromolecule-modified rod-shaped composite virus particles, and the rhabdovirus is fd bacteriophage. The preparation method comprises the following steps of: preparing a thermo-sensitive polymer solution; preparing a virus solution of the fd bacteriophage; dropwise adding the thermo-sensitive polymer solution into the virus solution to obtain thermo-sensitive macromolecule-modified composite virus particles; and dissolving the polymer-modified virus particles in a phosphoric acid buffer solution to obtain a solution, and heating the solution to a temperature higher than the gelation transformation temperature to obtain the hydrogel based on rhabdovirus. The preparation method disclosed by the invention has the advantages that the virus hydrogel has good biocompatibility and can generate quick and reversible sol-gel transformation at a specific gelation temperature point; massive chemical functional groups on the surface of the rhabdovirus can be bound with specific-function groups as chemical reaction hot spots; and after gel formation, the active groups on the skeleton surface are still available, and the hydrogel can be used as an insulin sustained-release intelligent material.

The invention discloses a titanium dioxide/thermo-sensitive polymer hybrid material as well as a preparation method and application thereof. The hybrid material is characterized in that nano-TiO2 is taken as a core, and a thermo-sensitive polymer, namely, poly-(glycol)ester ethylether-random-(glycol)methyl ether acrylic ester or poly-(glycol)ester ethylether-segmented-(glycol)methyl ether acrylicester is grafted onto the surface. Based on an SET-LRP (Single Electron Transfer-Living Radical Polymerization) method, a nitrogen-containing ligand which has high catalytic activity and tends to cause the disproportionation of copper is selected in the presence of a catechol initiator, so that strong complexing of a copper halide is realized, and the interference with a metal catalyst caused by acatechol group is realized in order to prepare a series of water-soluble polymers. The hybrid material is stable in structure, the low critical dissolving temperature of the water-soluble polymer isregulated and controlled by controlling the molecular weight of the polymer, uniform dispersion as well as self-fluctuation and recovery of TiO2 nanoparticles in water can be realized through a temperature switch, and sunlight photocatalytic degradation of target pollutants is realized. The hybrid material is suitable for sewage of different temperatures.

The invention discloses a production method of a microchip linear negative temperature coefficient thermistor. The production method includes: producing a thermo-sensitive polymer composite material similar to slurry, producing the evenly-stirred polymer composite material into a tape casting material, performing tape casting, gold foil layer coating, isostatic pressing, hot pressing and ultraviolet radiation crosslinking to produce the polymer-composite-material substrate of the thermistor, and precisely cutting the polymer-composite-material substrate according to product technical requirements to obtain the microchip linear negative temperature coefficient thermistor. The production method has the advantages that the produced microchip linear negative temperature coefficient (NTC) thermistor is high in resistance precision, adjustable in resistance, stable in resistance and TCR (temperature coefficient of resistance), reliable in product performance, and the like; the production method has important practical value to the industrial production of the microchip linear negative temperature coefficient thermistor.