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Dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and preparation method thereof

A technology for composite nanofibers and lactic acid polymers, which can be used in the preparation of spinning solutions, textiles, papermaking, nonwovens, etc. It can solve the problems of complex preparation process, difficult industrialization, and high experimental conditions of stimuli-responsive polymers. Inexpensive, simple synthetic route, abundant sources

Inactive Publication Date: 2014-11-05
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the above reasons, it is of great significance to study the new double hydrophilic thermosensitive polymer and lactic acid polymer composite nanofiber mat. The current research literature and patents have articles on the use of different hydrophilic and hydrophobic polymers to control the release of drugs. However, stimulation Responsive polymers have disadvantages such as complex preparation process, high experimental conditions, and difficulties in industrialization.

Method used

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  • Dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and preparation method thereof
  • Dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and preparation method thereof
  • Dual-hydrophilic thermo-sensitive polymer/lactic acid polymer composite nanofiber felt and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 3.96g of N-isopropylacrylamide, 2.34g of glucose divinyl adipate and 0.126g of AIBN into a flask equipped with a magnetic stirring rotor and an adapter, completely dissolve in 5mL of DMF, seal it, and repeatedly evacuate it. After several times of nitrogen, the reaction system was placed at 60°C under the protection of nitrogen and stirred for 24 hours. After that, the viscous colorless and transparent polymer solution obtained from the reaction was precipitated in a large amount of ether, and the ether was poured out, and the white solid precipitate was again Dissolve in a small amount of ethanol, repeatedly precipitate and dissolve until all unreacted monomers are washed out, and dry in a vacuum oven at 37°C for 24 hours to obtain a white solid powder.

[0038] Dissolve 0.2 g of the obtained white solid powder in 1 mL of pure alcohol, stir it magnetically for 4 h, and degas it by ultrasonication for 5 min.

[0039] Dissolve 0.2 g of poly(lactic acid-glycolic acid)...

Embodiment 2

[0042] Add 3.96g of N-isopropylacrylamide, 2.34g of glucose divinyl adipate and 0.126g of AIBN into a flask equipped with a magnetic stirring rotor and an adapter, completely dissolve in 5mL of DMF, seal it, and repeatedly evacuate it. After several times of nitrogen, the reaction system was placed at 60°C under the protection of nitrogen and stirred for 24 hours. After that, the viscous colorless and transparent polymer solution obtained from the reaction was precipitated in a large amount of ether, and the ether was poured out, and the white solid precipitate was again Dissolve in a small amount of ethanol, repeatedly precipitate and dissolve until all unreacted monomers are washed out, and dry in a vacuum oven at 37°C for 24 hours to obtain a white solid powder.

[0043] 0.4 g of the obtained white solid powder was dissolved in 1 mL of a mixed solution of alcohol and water with a volume ratio of 1:1, magnetically stirred for 3 h, and ultrasonically degassed for 4 min.

[00...

Embodiment 3

[0047] Add 3.96g of N-isopropylacrylamide, 2.34g of dextrose divinyl adipate and 0.126g of AIBN into a flask equipped with a magnetic stirring rotor and an adapter, completely dissolve in 5mL of DMF, seal it, and repeatedly evacuate it. After several times of nitrogen gas, the reaction system was placed at 60°C and stirred for 24 hours under the protection of nitrogen gas, and then the viscous colorless and transparent polymer solution obtained from the reaction was precipitated in a large amount of ether, and the ether was poured out, and the white solid precipitate was again Dissolve in a small amount of ethanol, repeatedly precipitate and dissolve until all unreacted monomers are washed out, and dry in a vacuum oven at 37°C for 24 hours to obtain a white solid powder.

[0048] 0.4 g of the obtained white solid powder was dissolved in 2 mL of a mixed solution of alcohol and water with a volume ratio of 1:1, magnetically stirred for 3 h, and ultrasonically degassed for 4 min. ...

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Abstract

The invention relates to a dual-hydrophilic thermo-sensitive polymer / lactic acid polymer composite nanofiber felt and a preparation method thereof. The nanofiber felt comprises the following components: dual-hydrophilic thermo-sensitive polymer and lactic acid polymer with the mass ratio of 10:1. The preparation method comprises the following steps: (1) carrying out free radical polymerization reaction on glucaric acid divinyl ester and N-isopropyl acrylamide to obtain the dual-hydrophilic thermo-sensitive polymer; (2) dissolving the high polymer in a solvent, stirring for 1-4 hours, and carrying out ultrasonic degassing to obtain a spinning solution A; (3) dissolving the lactic acid polymer in the solvent, stirring for 1-8 hours, carrying out ultrasonic degassing to obtain a spinning solution B; and (4) mixing the spinning solution A with the spinning solution B, and carrying out electrostatic spinning to obtain the dual-hydrophilic thermo-sensitive polymer / lactic acid polymer composite nanofiber felt. According to the invention, the method is continuously feasible, the operation is simple and easy, industrialization is easy to realize, and the obtained nanofiber felt can be used for carrying medicines and control the release of the medicine; and the nanofiber felt can also be implanted into a release system and can be used in the fields of tissue engineering scaffold and the like.

Description

technical field [0001] The invention belongs to the field of environment-sensitive nanofiber felt and its preparation, in particular to a double-hydrophilic temperature-sensitive polymer / lactic acid polymer composite nanofiber felt and a preparation method thereof. Background technique [0002] Biomedical polymer materials are widely used in the fields of life science, medicine and material science, and are polymer materials used for diagnosis, treatment, repair or replacement of tissues and organs. In the field of medicine, especially in the clinical field, it has been widely used in the fields of drug controlled release, artificial organs, dental materials and tissue engineering. After years of development, biomedical polymers have been widely used in the field of biomedical materials. [0003] A new material that can respond to changes in the surrounding environment is a smart material, which has great application prospects in modern medical treatment. Smart polymer mat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4382D04H1/728D01D1/02C08F220/54
Inventor 朱利民张婳权静娄少峰田利强
Owner DONGHUA UNIV
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