Paclitaxel-loaded ethylene-vinyl acetate esophageal stent and preparation method thereof

Abstract

The invention pertains to the field of medical instruments and discloses a paclitaxel-loaded ethylene-vinyl acetate esophageal stent and a preparation method thereof. The stent is composed of a bare metal stent and a covering film covering the bare metal stent. The covering film comprises an ethylene-vinyl acetate esophageal backing layer and a paclitaxel medicine film layer. The inside of the ethylene-vinyl acetate esophageal backing layer is closely adhered to the bare metal stent. The outside of the ethylene-vinyl acetate esophageal backing layer is adhered to the paclitaxel medicine film layer. The stent is 50% in the theoretical drug-loading amount ranges from 48.26% -50.81% in the measured drug-loading amount. Within 80d, paclitaxel ranges from 615.274-1101.368 [mu]m / cm2 in the accumulative releasing amount and ranges from 57.93-108359 [mu]m / cm2 and also ranges from 57.93-108359 [mu]m / cm2 in the infiltration amount from the backing layer. The paclitaxel-loaded ethylene-vinyl acetate esophageal stent and the preparation method thereof have following beneficial effects: the preparation method is easily and conveniently applied; the good mechanical property is obtained; the slow release function can be fulfilled for a long time; and the stent has good functions of mechanical support and prevention against growth inside of tumors.

Description

technical field [0001] The invention relates to a drug-loaded polymer film-covered stent in the field of medical devices, in particular to an ethylene-vinyl acetate esophageal stent loaded with paclitaxel and a preparation method thereof, which are applied to the treatment of esophageal lumen strictures. Background technique [0002] Stents are an ideal drug delivery system. Traditional stents do not have a positive therapeutic effect, but only play a palliative role in mechanical support and short-term maintenance of cavity opening. Compared with ordinary bare metal stents, drug-loaded stents add two parts, one is drugs, which can inhibit intimal hyperplasia and prevent restenosis; the other is drug carriers, which are often synthetic polymers with good biocompatibility . Drug release from the drug-loaded layer must be controlled and predictable. To achieve this goal, it is necessary to select a suitable drug-loading material. In the non-vascular field, there is no drug...

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Problems solved by technology

[0003] After searching the literature of the prior art, it was found that the Chinese patent publication number is CN2638761Y, the publication date is September 8, 2004, and the patent name is esophageal drug stent, which is a kind of stent implanted into the narrow segment of esophagus tumor by a conveyor. The esophageal drug stent has the disadvantages of insufficient drug loading, and the second is that the release of 5-fluorouracil in the silicone rubber film is slow.

The shortcomings of the current research are that the type of EVA used is single, the choice of the backing layer is lacking, and the release of paclitaxel in the membrane material is slow, which cannot effectively regulate and control the release of the drug.

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