Non-invasive systems and methods for in-situ photobiomodulation
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一种生物活性、调节剂的技术，应用在光疗法、消化系统、光动力疗法等方向，能够解决治疗依赖等问题
Inactive Publication Date: 2016-02-03
IMMUNOLIGTHT LLC +1
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However, each has the disadvantage that the therapy relies on the production of singlet oxygen to obtain the desired effect on the treated tissue, thus affecting largely indifferently the healthy cells and the diseased tissue desired to be treated
Another problem encountered with PDT treatment is the inability to treat the target area beyond a few centimeters below the skin surface without using significantly invasive methods
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[0564] Preparation of liposomes. The liposome preparation method was modified from Wait P., Bach, M., T., Nahde, T., Hoffmann, S., Müller, R., and Kontermann, R.E., Novel RG Dlipopeptides for the targeting of liposomes to integrin-expressing endothelia and melanoma cells. Protein Engineering Design and Selection, 2004.17(5): p.433-441]. Briefly, lipid PEG-DPPE, PC and Rh-DPPE were mixed in chloroform in a round bottom flask and evaporated (Hieroglyph Rotary Evaporator, Rose Scientific Ltd., Edmonton, Alberta, Canada) to remove chloroform. The dry film was dehydrated into the aqueous phase using PBS solution. Dry lipid films were prepared by rotary evaporation from a mixture of PC, cholesterol and PEG-DPPE, then hydrated into the aqueous phase using PBS. The mixture was mixed vigorously by vortexing, then the suspension was extruded through a polycarbonate filter (Avestin Inc., Ottawa, ON, Canada) (pore size 0.8 μm) using a Liposofast apparatus in a water bath (Instrume...
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[0648] Preparation of silver nanoparticles
[0649] Silver (or gold) colloids were prepared according to the standard Lee-Meisel method: 200ml10 -3 M AgNO 3 The aqueous solution was boiled, then 5 ml of 35-mM sodium citrate solution was added, and the resulting mixture was kept boiling for 1 hour. It has been reported that this method yields ~10 11 Colloidal particles with a uniform size of 1 particle / ml, the diameter is ~35-50nm, and the maximum absorption is at 390nm. The colloidal solution was stored at 4°C and protected from room light. The colloidal solution was further diluted with distilled water.
[0650] Fabrication / Preparation of Metallic Nanocaps
[0651] One approach involves the use of nanospheres spin-coated on a solid support to create and control the desired roughness. The nanostructured support is subsequently covered with a silver layer, which provides the conduction electrons required for the surface plasmon mechanism. Among solid support based method...
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Abstract
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, include treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. The invention provides kits containing products or compositions formulated or configured and systems for use in practicing these methods.
Description
[0001] This application is a divisional application of the application number 200980121111.5 and the title of the invention is "Non-invasive system and method for in situ photobiomodulation". The parent application is the PCT application PCT filed on April 2, 2009 / US2009 / 039300 entered the Chinese national phase application. [0002] Cross References to Related Applications [0003] This application is related to U.S. Patent Application 11 / 935,655, filed November 5, 2007; U.S. Patent Application 12 / 059,484, filed March 31, 2008; U.S. Patent Application 12 / 389,946, filed February 20, 2009; 2008 US Provisional Patent Application 61 / 042,561, filed April 4, each of which is hereby incorporated by reference in its entirety. technical field [0004] The present invention relates to methods and systems for treating a disease or disorder in a subject, which provide a better distinction between normal healthy cells and cells with a disease or disorder (hereinafter "target cells"), a...
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