A kind of preparation method of highly elastic anti-wrinkle artificial blood vessel

Abstract

The invention relates to a high-elasticity crease-resistant artificial blood vessel and a preparation method thereof, and belongs to the technical field of biomedical engineering. The artificial blood vessel is prepared by extruding a mixed solution of polyurethane and polycaprolactone through a metering pump, pre-coagulating the mixed solution by virtue of a coagulating bath and winding the pre-coagulated material by virtue of a rotatable cylindrical mold. The prepared artificial blood vessel is a tubular object having a cellular structure. By adding a little of the polycaprolactone to the polyurethane material, the flexibility of the material is enhanced and the crease resistance of the artificial blood vessel is improved. The longitudinal tensile property and the uniformity of the artificial blood vessel disclosed by the invention are improved through a winding mode of intersected distribution in axial and radial directions. The artificial blood vessel prepared by the invention is simple in process, and excellent in strength, compliance, fatigue resistance and crease resistance.

Description

technical field [0001] The invention relates to a preparation method of an artificial blood vessel, in particular to a preparation method of a highly elastic anti-wrinkle artificial blood vessel which is not easy to bend to form a dead angle and is not easy to cause blockage after being implanted into a human body, and has good antithrombotic and biocompatibility, and belongs to biomedicine field of engineering technology. Background technique [0002] With the improvement of human living conditions, the incidence of vascular diseases is also increasing. One of the effective means of treating vascular diseases is vascular transplantation. In medicine, one's own venous blood vessels are generally used to replace necrotic arterial blood vessels, but artificial blood vessels can be used to connect the two ends of the blood vessels under the premise that the own venous blood vessels cannot be obtained, so as to maintain normal blood transport and make blood The cycle is restore...

AI Technical Summary

Problems solved by technology

[0003] Chinese Patent Publication No. CN102698320A, the date of publication is October 3, 2012, and the title of the invention is: the application of a new nano-material of polytetrafluoroethylene, which is a self-assembled functional MWNT film layer by layer on a polytetrafluoroethylene substrate Clinically, the combination of multi-walled carbon nanotubes and PTFE vascular materials can reduce the degree of vascular intimal hyperplasia after artificial vascular implantation and improve the patency rate of blood vessels in animal experiments. However, small-caliber PTFE is used in bypass surgery. Blood vessels, whose patency rate is very low, can easily block blood vessels, and the elasticity and compliance of blood vessels are poor

The blood vessel process is complicated, the cost is high, and the warp and weft interweaving density is high, the elasticity of the blood vessel is limited, and there is no bonding between the yarns, forming micropores, easy to bleed, and need to be pre-coagulated before use, which cannot meet the clinical use requirements

[0005] Chinese Patent Publication No. CN101007186A, the publication date is August 1, 2007, and the name of the invention is: a fabric-reinforced composite artificial blood vessel, in which the tubular fabric is embedded in the artificial blood vessel skeleton composed of polyurethane and ultrafine protein powder Among them, and grafting sulfonic acid groups on the surface, the advantage is to improve the anti-permeability, hemocompatibility and tissue compatibility of the artificial blood vessel, but the invention uses the extraction method to prepare the artificial blood vessel, and there are two ends of the wall thickness The difference is large, and it is easy to form thrombus during use, and the anti-wrinkle ability is not enough, etc.

[0006] Chinese Patent Publication No. CN103156707B, the publication date is August 5, 2015, and the name of the invention is an artificial blood vessel preparation device. The invention introduces a hollow double-layer device to solidify and form the artificial blood vessel in the double-layer gap. The advantage is that the size of the artificial blood vessel prepared by this method is controllable, the inner and outer diameters are accurate, the coaxiality is high, and the wall thickness is uniform, which is suitable for the preparation of artificial blood vessels of various specifications. However, the device has a complex structure, cumbersome preparation process, and high requirements

[0007] Chinese Patent Publication No. CN102008755B, the publication date is April 13, 2011, and the name of the invention is a polyethylene terephthalate and polyurethane composite artificial blood vessel and its preparation. The invention consists of polyethylene terephthalate and polyurethane The polyurethane mixed solution is prepared by an electrospinning device. Mixing two materials with different mechanical properties to prepare a product can make up for the shortcomings of a single material product. Therefore, the artificial blood vessel prepared by this invention has high strength, elasticity and compliance. Large size, good biocompatibility, strong anticoagulation, and high cell adhesion, etc., but it takes a long time to prepare by electrospinning device, the preparation conditions are high, and the anti-wrinkle performance of the artificial blood vessel is poor

[0008] Chinese Patent Publication No. CN103933609, the date of publication is July 23, 2014, and the title of the invention is a one-time molded polyurethane artificial blood vessel and its preparation method. The obtained artificial blood vessel has good wall thickness uniformity, but the axial strength is weak, and it is difficult to resist the impact of blood pressure by only relying on bonding to form the blood vessel wall. At the same time, the anti-wrinkle performance needs to be further improved

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