A centrifugal air electrospinning device for mass production of three-dimensional nanofibrous scaffolds

A three-dimensional nano-fiber scaffolding technology, which is applied in fiber processing, electrospinning, textiles and papermaking, etc., can solve the problems of low jet starting voltage and nozzle clogging, and achieve the effects of increased thickness, fluffy structure and favorable cell growth

Active Publication Date: 2018-05-22
FOSHAN QINGZI PRECISION MEASUREMENT & CONTROL TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the above problems, the present invention provides a centrifugal gas electrospinning device for preparing a large number of three-dimensional nanofiber scaffolds, which requires lower jet start-up voltage, smaller fiber diameter, greatly improved production, and can efficiently obtain a large number of three-dimensional nanofibers bracket, while avoiding the problem of nozzle clogging

Method used

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  • A centrifugal air electrospinning device for mass production of three-dimensional nanofibrous scaffolds
  • A centrifugal air electrospinning device for mass production of three-dimensional nanofibrous scaffolds
  • A centrifugal air electrospinning device for mass production of three-dimensional nanofibrous scaffolds

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Embodiment 1

[0032] The centrifugal air electrospinning device for preparing a large number of three-dimensional nanofiber scaffolds disclosed in the present invention, when used, first prepares the spinning solution, weighs 1200 mg of PLLA (molecular weight = 200,000 Daltons), dissolves it in 20 ml (9 :1,CH 2 Cl 2 / DMF, v / v) solvent, prepared 6% PLLA solution, sealed with parafilm, magnetically stirred for 4 hours, and set aside.

[0033] The PLLA solution is loaded into the feed port 12, the high-voltage positive pressure power supply 61, the air supply device 7 are connected with the centrifugal nozzle 1, and a plurality of open rotary receiving devices 2 are respectively connected with the high-voltage negative pressure power supply 62 through the negative pressure power supply line to adjust the centrifugation. The distance between the nozzle 1 and the open rotary receiving device 2 is 10cm, turn on the second motor switch of the open rotary receiving device 2, turn on the high-volta...

Embodiment 2

[0035] The centrifugal air electrospinning device for preparing a large number of three-dimensional nanofiber scaffolds disclosed in the present invention uses polylactic acid as a raw material, and 10 grams of polylactic acid is added to the feed port 12, and the high-voltage positive pressure power supply 61 is connected to the centrifugal nozzle 1. A plurality of open rotary receiving devices 2 are respectively connected to negative high voltage power supply 62 through negative voltage power lines, adjust the distance between the centrifugal nozzle 1 and the open rotary receiving device 2 to be 10 cm, and then turn on the switch of heating device 5 to make the polylactic acid Heat the centrifugal nozzle 1 to a molten state, turn on the second motor switch of the open rotary receiving device 2, turn on the switch of the high-voltage positive voltage power supply 61 and the negative high-voltage power supply 62, and adjust the output positive voltage to be 5KV DC high voltage, ...

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Abstract

The invention discloses a centrifugal gas electro-spinning device used for preparing a large number of three-dimensional nanofiber scaffolds. The device comprises a high-voltage power supply device, a gas supply device, centrifugal sprayers, open rotary receiving devices and a centrifugal drive mechanism. A liquid storage cavity is formed in each centrifugal sprayer, and thin yarn outlets are formed in the centrifugal sprayers. Each open rotary receiving device comprises a rotary shaft, a transmission device and a plurality of supporting arms. The supporting arms can form a bowl-shaped rotary face when rotating along with the rotary shafts. A plurality of the open rotary receiving devices are arranged. The centrifugal sprayers are distributed to form an annular shape in a center mode. The high-voltage power supply device and the centrifugal sprayers are connected with the open rotary receiving devices to form an electric field required by generation of solutions or melt jet flow. The centrifugal sprayers are provided with gas guide channels connected with the gas supply device so that auxiliary drawing air flow can be generated. Polymer which is jetted forms nanofibers through the electric field, the air flow and centrifugal force, compatibility to biological materials is better, the material application range is wide, and the obtained scaffold structures facilitate cell growth in tissue engineering application.

Description

technical field [0001] The invention is used in the technical field of centrifugal spinning, and in particular relates to a centrifugal air electrospinning device for preparing a large number of three-dimensional nanofiber supports. Background technique [0002] Electrospinning technology is currently the most important method for preparing nanofibers. The core of this technology is to make the charged jet stretch and deform in an electrostatic field, and finally obtain a fibrous substance, thus providing a new processing method for polymer nanomaterials. Electrospinning technology has the advantages of simple operation, wide application range, and relatively high production efficiency. The spun nanofibers have the characteristics of fine fibers, large specific surface area, and high porosity. Therefore, electrospinning technology has been widely used. [0003] The traditional electrospinning method is mostly DC electrospinning method, which uses a DC high voltage power sup...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/00D01D5/18
CPCD01D5/0007D01D5/18
Inventor 房飞宇王晗陈新陈新度吴磊梁烽曾俊朱自明
Owner FOSHAN QINGZI PRECISION MEASUREMENT & CONTROL TECH
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