Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for producing a polymer porous support in batch

A technology of porous scaffolds and polymers, applied in coatings, medical science, prostheses, etc., can solve the problems of solvent residues, time-consuming preparation methods, and porogen residues, etc., to improve internal connectivity and cell compatibility. performance, high efficiency

Inactive Publication Date: 2016-04-06
SOUTH CHINA UNIV OF TECH
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the various methods derived from the above preparation of polymer porous scaffolds can prepare scaffold materials with high porosity and good mechanical properties, they have problems with the traditional preparation processes such as porogen residues in the particle leaching method, thermally induced There are solvent residues in the phase separation method, and the lack of internal connectivity of the cells in the gas foaming method has made a lot of improvements, but most of the preparation methods take a long time, and the polymer matrix materials involved in the preparation of tissue engineering scaffolds are mostly artificially synthesized. Polymer materials lack cell binding sites, and chemical grafting of natural polymers on the surface of the scaffold will adversely affect the performance of the scaffold

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for producing a polymer porous support in batch
  • Method for producing a polymer porous support in batch
  • Method for producing a polymer porous support in batch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) After PCL and PEO are vacuum-dried, they are placed in a twin-screw extruder for melt blending, the content of PEO is 50% of the total mass of PCL and PEO, the temperature of the extrusion die is 100 ° C, and the screw speed is 100rad / s.

[0031](2) After the blend prepared in step (1) is plasticized and melted on the twin-screw extruder, supercritical nitrogen is injected into the melt, the constant pressure is 15MPa, the extrusion die temperature is 100°C, and the screw speed is 100rad / s; PCL / PEO foam material was prepared.

[0032] (3) Place the PCL / PEO foam material prepared in step (2) in a continuous circulating water flow device, filter for 24 hours, filter out the PEO phase, and obtain a PCL porous scaffold after vacuum drying for 24 hours.

[0033] (4) The PCL porous scaffold obtained in step (3) is placed in a chitosan solution with a mass concentration of 0.01% and soaked for 12 hours. The solvent used in the chitosan solution is acetic acid with a mass ...

Embodiment 2

[0035] (1) After PCL and PEO are vacuum-dried, they are placed in a twin-screw extruder for melt blending, the content of PEO is 50% of the total mass of PCL and PEO, the temperature of the extrusion die is 100 ° C, and the screw speed is 100rad / s.

[0036] (2) The blend prepared in step (1) is used as the base material, and the NaCl that the mass fraction is 10% (that is, the mass is 10% of the total mass of the polycaprolactone and the polymer porogen phase) is added in the twin-screw extruder Melt blending is carried out on the extruder, supercritical nitrogen is injected into the melt, the constant pressure is 15MPa, the temperature of the extrusion die is 100°C, and the screw speed is 100rad / s; the PCL / PEO / NaCl foam material is obtained.

[0037] (3) The PCL / PEO / NaCl foaming material prepared in the step (2) is placed in a continuous circulating water flow device, the filtration time is 24h, the porogen phase PEO and NaCl are filtered off, and the PCL porous support is ob...

Embodiment 3

[0040] (1) After PCL and PEO are vacuum-dried, they are placed in a twin-screw extruder for melt blending, the content of PEO is 50% of the total mass of PCL and PEO, the temperature of the extrusion die is 100 ° C, and the screw speed is 100rad / s.

[0041] (2) The blend prepared in step (1) is used as the base material, and the NaCl that the mass fraction is 10% (that is, the mass is 10% of the total mass of the polycaprolactone and the polymer porogen phase) is added in the twin-screw extruder Melt blending is carried out on the extruder, supercritical nitrogen is injected into the melt, the constant pressure is 15MPa, the temperature of the extrusion die is 100°C, and the screw speed is 100rad / s; the PCL / PEO / NaCl foam material is obtained.

[0042] (3) The PCL / PEO / NaCl foaming material prepared in the step (2) is placed in a continuous circulating water flow device, the filtration time is 24h, the porogen phase PEO and NaCl are filtered off, and the PCL porous support is ob...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for producing a polymer porous support in batch, wherein the polymer porous support is prepared by combining a supercritical fluid extrusion foaming method and a freeze-drying method, and substantially comprises steps: (1) preparation of polycaprolactone base composite foaming materials; (2) filtering of pore-foaming agent phases; (3) leading of chitosan three-dimensional network. The method for producing the polymer porous support in batch has the advantages that the method for producing the polymer porous support in batch uses continuous production to extrude and foam, is high in production efficiency of porous supports, can obviously improve internal communication of the porous supports by leading in the pore-foaming agent phase, guarantees an pore-foaming agent to be rapidly filtered without obvious residual by combining a physical foaming agent and the pore-foaming agent, and belongs to the field of medial materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and discloses a method for mass production of porous polymer scaffolds, in particular to a three-dimensional chitosan-containing network prepared by combining supercritical fluid extrusion foaming and freeze-drying A method for polycaprolactone porous scaffolds. Background technique [0002] The preparation of porous scaffolds is one of the important research contents in the field of tissue engineering research. It mainly plays the role of extracellular matrix, guides cells to grow on it and then generates new target tissues or organs, and replaces or repairs diseased tissues. damage to organs or tissues. Since the concept of porous scaffolds for tissue engineering was proposed, researchers have developed a variety of methods for preparing porous scaffolds, such as electrospinning, thermally induced phase separation, solution casting / particle leaching, and gas foaming. [0003] Electrospinni...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/18A61L27/34A61L27/50A61L27/56C08J7/04C08J9/26
CPCA61L27/18A61L27/34A61L27/50A61L27/56C08J7/0427C08J9/26C08J2367/04C08J2405/08C08L67/04C08L5/08
Inventor 经鑫彭响方米皓阳童立生
Owner SOUTH CHINA UNIV OF TECH