Double-functional-layer oral restoration membrane and preparation method thereof

Abstract

The invention relates to a double-functional-layer oral restoration membrane and a preparation method thereof. The restoration membrane is formed by a loose porous layer and a dense antibacterial layer. The loose porous layer is formed by collagen I, oxidized polysaccharide and beta-tricalcium phosphate. The dense antibacterial layer is formed by compounding collagen I and oxidized chitosan. The restoration membrane has good mechanical performance, hydrophilia and biocompatibility, certain bacteria resistance and bacteriostasis performance and suitable and controllable degradation absorbability, preparation operation is easy, a good mechanical barrier effect is achieved, meanwhile, bonding of osteoblast and the membrane is facilitated, and Ca2+, P3- and the like are provided for formation of new teeth.

Description

technical field [0001] The invention relates to a double-functional oral cavity repair film and a preparation method thereof, belonging to the field of oral medical materials. Background technique [0002] In recent years, with the continuous development and progress of tissue engineering, a new repair technology—membrane guided tissue regeneration (MGBR) was born. The generation of MGBR has greatly improved the level of oral restorative science. [0003] Membrane for oral restoration is to place the membrane between oral soft tissue and bone defect by surgical operation to establish a biological barrier, so as to create a relatively closed environment for bone regeneration and selectively block fibroblasts and epithelial cells that migrate faster A biocompatible material that enters the bone defect area without hindering the natural healing of the wound. Dental repair films can be subdivided into: collagen film, metal film, synthetic film and allogeneic periosteum accordin...

AI Technical Summary

Problems solved by technology

But when it is used alone, it cannot meet the multifunctional requirements of oral restoration membrane, so it is often combined with other materials to achieve better performance (TaguchiY, AmizukaN, NakadateM, et al.Ahistologicalevaluationforguidedboneregenerationinducedbyacollagenousmembrane[J]. :6158-6166.)

[0005] Chitosan, also known as deacetylated chitin, is a natural polymer with good biocompatibility and almost no antigenicity. It also has the functions of inducing tissue regeneration, hemostasis, antibacterial and antibacterial, etc. Medical materials, but the mechanical properties and biodegradability of pure chitosan film are poor, so it is not suitable for oral repair film materials, so people often modify chitosan or blend with other materials to improve its performance to achieve oral repair film Material requirements (PrabaharanM.Reviewpaper:chitosanderivativespromisingmaterialsforcontrolleddrugdelivery[J].JBiomaterAppl,2008,23(1):5-36.)