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A method for producing broken-wall Haematococcus pluvialis powder

A technology of Haematococcus pluvialis powder and Haematococcus pluvialis, which is applied in the directions of microorganism-based methods, biochemical equipment and methods, and microorganism dissolution, etc., can solve the problem that the liquid nitrogen grinding method is not suitable for large-scale industrial production, and the It is difficult to improve the wall rate and the use conditions are harsh, so as to achieve the effects of extending the operation cycle and service life of the equipment, reducing the oxidation loss and reducing the homogenization pressure.

Active Publication Date: 2020-02-21
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Enzymatic hydrolysis and acid hydrolysis have low wall breaking rates (usually less than 70%), liquid nitrogen grinding method is not suitable for large-scale industrial production, and high pressure homogenization usually cannot break the wall of smaller chlamydospores, resulting in It is difficult to increase the wall breaking rate. In order to increase the wall breaking rate, some need high-pressure homogenization several times, and some need to increase the pressure to 150-200MPa. The conditions are harsh and the production is difficult. Even so, the wall breaking rate is only 90-93 %, and there are problems such as serious loss of astaxanthin in the drying process after breaking the wall

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 8kg of Haematococcus pluvialis mud, the water content is 53%, the dry matter astaxanthin content is 5.1%, add hydrochloric acid to make the acid solution 0.2%, stir evenly and place it for 30min; filter the material solution through plate and frame to remove acid Add 20kg of ethanol solvent to the algae mud, stir evenly, break the wall once through a homogenizer, and the pressure is 30MPa; remove the solvent by distillation under reduced pressure to obtain 3.72kg of broken-wall algae powder with an astaxanthin content of 5.0%, measured The wall breaking rate was 98.5%, and the astaxanthin content recovery rate was 97.0%.

Embodiment 2

[0028] Weigh 20kg of Haematococcus pluvialis mud, the water content is 47%, the dry matter astaxanthin content is 3.50%, add phosphoric acid to adjust the solution concentration to 1%, stir evenly and place it for 60 minutes; filter the material solution through a plate frame to remove the acid solution , add 35 kg of ethyl acetate solvent to the algae mud, stir evenly, and remove impurities by passing through an 80-mesh screen; the wall is broken by a homogenizer, and the pressure is 35 MPa, and the number of times is 1; after standing to be separated, remove 7 kg of the upper solvent, The solvent was removed by distillation under reduced pressure in the lower layer to obtain 9.21 kg of broken Haematococcus pluvialis powder with an astaxanthin content of 3%, and the measured breaking rate was 99.3%. The separated upper solvent was filtered and vacuum distilled to obtain 1.34 kg of astaxanthin oil with a content of 6.1%, and the yield of astaxanthin was 96.5%.

Embodiment 3

[0030] Weigh 20kg of Haematococcus pluvialis mud, the water content is 53%, the dry matter astaxanthin content is 3.70%, add oxalic acid to adjust the solution concentration to 0.01%, stir evenly and place it for 20 minutes; filter the material liquid through a plate frame to remove Acid solution, add 28.2kg of ethyl acetate solvent to the algae mud, stir evenly, and remove impurities through a 80-mesh screen; break the wall with a homogenizer, the pressure is 20MPa, and the number of times is 1; after standing for stratification, remove 7.5 kg upper layer solvent, and the lower layer decompressed distillation to remove the solvent to obtain 8.05 kg of broken Haematococcus pluvialis powder with an astaxanthin content of 3.2%, and the measured breaking rate was 98.7%. The separated upper solvent was filtered and vacuum distilled to obtain 1.3 kg of astaxanthin oil with a content of 6.2%, and the yield of astaxanthin was 97.24%.

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Abstract

The invention relates to a method for producing wall-broken haematococcus pluvialis powder. The method specifically includes: adding acid aqueous solution into haematococcus pluvialis paste, and well mixing to obtain mixed liquid; centrifuging or filtering the mixed liquid to remove moisture so as to obtain solid substances; adding organic solvent into the solid substances, and using a homogenizer for wall breaking to obtain wall-broken haematococcus pluvialis paste; performing heating distillation on the wall-broken haematococcus pluvialis paste to remove the solvent so as to obtain the wall-broken haematococcus pluvialis powder. The wall breaking rate of the wall-broken haematococcus pluvialis powder reaches up to 98%, and the astaxanthin content loss of the wall-broken haematococcus pluvialis powder is smaller than 4.0%.

Description

technical field [0001] The invention belongs to the technical field of natural component extraction and refining, and relates to a method for producing broken-wall Haematococcus pluvialis powder. Background technique [0002] At present, the highest content of natural astaxanthin is Haematococcus pluvialis, which is a single-celled green algae that lives in fresh water. It is generally believed that when the environment is unfavorable, it will form thick-walled spores and accumulate a large amount of astaxanthin. Astaxanthin has a bright red color and strong antioxidant properties. Animal experiments have shown that astaxanthin has many physiological functions such as delaying aging and enhancing immunity. However, because the spores of Haematococcus pluvialis have a tough cell wall, if they are directly used, the effective bioavailability will be reduced, so the wall of Haematococcus pluvialls must be broken before use. [0003] At present, the wall-breaking methods of Hae...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/06C12R1/89
CPCC12N1/06
Inventor 王红霞田洪杨君龙牛志平
Owner CHENGUANG BIOTECH GRP CO LTD