A kind of preparation method of graphene oxide antibacterial mildew-proof medical bandage

A technology of antibacterial and antifungal, antibacterial and antifungal agent, applied in bandages, ether preparation, medical science and other directions, to achieve the effects of excellent bactericidal performance, enhanced cohesion and low cost

Active Publication Date: 2018-05-04
张建刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used in the application of wild lily extract in the field of medicine, but there are few reports on the application of its extract in the field of antibacterial and antifungal medical devices for medical bandages

Method used

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  • A kind of preparation method of graphene oxide antibacterial mildew-proof medical bandage
  • A kind of preparation method of graphene oxide antibacterial mildew-proof medical bandage
  • A kind of preparation method of graphene oxide antibacterial mildew-proof medical bandage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Isolation, preparation and structure confirmation of wild lily extract compounds:

[0024] Preparation method: (a) The dried whole herb of Wild Lily (10kg) is pulverized, extracted with 80% ethanol under heat reflux (25L×3 times), the extracts are combined, concentrated to no alcohol smell (3L), and successively washed with petroleum ether (3L ×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract (398g) and n-butanol extract respectively; (b) In the step (a), the ethyl acetate extract is removed with AB-8 type macroporous resin, first eluted with 10% ethanol for 8 column volumes, then with 75% ethanol for 10 column volumes, and collected 75 % ethanol eluate, concentrated under reduced pressure to obtain 75% ethanol eluate extract (163g); (c) 75% ethanol eluate extract in step (b) is separated with 200-300 mesh normal phase silica gel, and the volume The ratios are 85:1 (8...

Embodiment 2

[0027] A method for preparing a graphene oxide antibacterial and antifungal medical bandage, the method comprising: uniformly distributing the prepared antibacterial and antifungal agent on gauze through a spraying process to obtain an antibacterial and antifungal medical bandage.

[0028] The antibacterial and mildew-proof enzyme agent comprises in parts by weight: 0.5 part of nano-graphene oxide, 0.05 part of nano-loaded metal graphene oxide, 1.3 part of nano-calcium carbonate, 0.02 part of wild lily extract compound, 1.0 part of polyethylene glycol, 0.2 parts of polyvinylpyrrolidone, 50 parts of water.

[0029] The nanographene oxide has a purity of ≥99%, a sheet thickness of 0.5nm, and a sheet length of 500nm.

[0030] The supported metal of the nano-supported metal graphene oxide can be silver.

[0031] The structural formula and preparation method of the described wild lily extract compound are the same as in Example 1.

[0032] The preparation method of the antibacter...

Embodiment 3

[0036] A method for preparing a graphene oxide antibacterial and antifungal medical bandage, the method comprising: uniformly distributing the prepared antibacterial and antifungal agent on gauze through a spraying process to obtain an antibacterial and antifungal medical bandage.

[0037] The antibacterial and mildew-proof enzyme agent comprises in parts by weight: 1.55 parts of nano-graphene oxide, 0.55 part of nano-loaded metal graphene oxide, 9.5 parts of nano-calcium carbonate, 0.65 part of wild lily extract compound, 5.5 parts of polyethylene glycol, 1.8 parts of polyvinylpyrrolidone, 120 parts of water.

[0038] The nano-graphene oxide has a purity of ≥99%, a sheet thickness of 2nm, and a sheet length of 900nm.

[0039] The supported metal of the nano-supported metal graphene oxide may be copper.

[0040] The structural formula and preparation method of the described wild lily extract compound are the same as in Example 1.

[0041] The preparation method of the antiba...

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Abstract

The invention relates to a preparing method of a graphene oxide antibacterial mildew-resistant medical bandage. The method includes evenly spraying gauze with a prepared antibacterial mildew-resistant agent through a spraying process to obtain the antibacterial mildew-resistant medical bandage. Antibacterial mildew-resistant and peculiar smell-removing effects of the bandage are significantly improved through synergistic effects of nanometer graphene oxide, a wild lily bulb extract and nanometer metal-supported graphene oxide. The mildew-resistant level of the bandage is the zero level. The bacteriostatic rate of the bandage for staphylococcus aureus is 99.91%, the bacteriostatic rate of the bandage for escherichia coli is 99.23%, the bacteriostatic rate of the bandage for helicobacter pylori is 99.0%, the bacteriostatic rate of the bandage for candida albicans is 98%, and the bacteriostatic rate of the bandage for mould is 100%. For the gauze sprayed with the antibacterial mildew-resistant agent, nanometer particles penetrate into the gauze and inner cohesiveness of the gauze is enhanced, and therefore hairiness is greatly reduced, and secondary wounds when the bandage is used by a patient are avoided.

Description

technical field [0001] The invention relates to a preparation method, in particular to a preparation method of a graphene oxide antibacterial and antifungal therapeutic bandage. It belongs to the field of new material technology. Background technique [0002] Medical bandages are elastic dressing materials that became popular in the early 1980s. Medical bandages have good elasticity and comfort, and are mostly used in sports protection and medical fields. Because medical bandages have continuous elasticity and non-slip properties that traditional bandages do not have, medical bandages play an indispensable role in medical care and treatment. However, the currently used medical bandages have hairiness, allergies, mildew and other phenomena, and are easy to stick and infect the wound, causing secondary trauma. [0003] Graphene oxide is the oxide of graphene, its color is brownish yellow, and the common products on the market are powder, flake and solution. After oxidation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/18A61L15/20A61L15/24A61L15/44A61L15/46C07C41/34C07C43/23
CPCA61L15/18A61L15/20A61L15/24A61L15/26A61L15/46A61L2300/10A61L2300/216A61L2300/404C07C41/34C07C43/23C08L71/02C08L39/06
Inventor 张建刚张重静王兰芳
Owner 张建刚
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