Preparation of dual-responsive injectable supramolecular intelligent hydrogel

Abstract

The invention relates to a preparation method of a pH and oxidation dual-responsive injectable supramolecular intelligent hydrogel. The hydrogel involved in the invention is composed of dual response method for preparing injectable supramolecular intelligent hydrogels. The hydrogel of the invention is composed of double-selenium containing multiblock polyether polyurethane, alpha-cyclodextrin, a loaded drug and water. The preparation process consists of: firstly introducing a double-selenium bond to a polyurethane main chain with good biocompatibility and pH sensitivity, then loading a hydrophobic drug at the same time of self-assembly into nanoparticles, finally introducing alpha-cyclodextrin molecules into the nanoparticle solution and letting the alpha-cyclodextrin molecules interpenetrate to a polyethylene glycol chain so as to obtain the supramolecular intelligent hydrogel, and loading the hydrophobic drug at the same time. The hydrogel has shear thinning property, and can be easily injected, is sensitive to pH and oxidation reduction environment, also can be oxidized and degraded through the introduced double-selenium bond, and has good application prospect in the biomedicine field as a common controlled-release carrier of hydrophilic and hydrophobic drugs.

Description

technical field

[0001] The invention relates to the application of an injectable supramolecular hydrogel in the technical field of biomedical controlled release carriers, in particular to a preparation method of a dual-responsive injectable supramolecular intelligent hydrogel. Background technique

[0002] The drug controlled release of hydrogel is to load the drug on the drug controlled release carrier gel, and the drug can permeate through the pores of the carrier gel in vivo or diffuse to the designated lesion through the gradual decomposition of the carrier gel. This permeation or diffusion effect is relatively slow, so that the loaded drug can be continuously released at a certain concentration, thereby prolonging the action time of the drug to fully exert the drug effect and avoiding high frequency of administration.

[0003] Polymers with amphiphilic segments can self-assemble into colloidal particles with shell-core structure in aqueous solution. Among them, the hyd...