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Preparation of dual-responsive injectable supramolecular intelligent hydrogel

A hydrogel and responsive technology, applied in the field of injectable supramolecular hydrogel in the field of biomedical controlled release carrier, can solve the problem of not achieving simultaneous controlled release of hydrophilic and hydrophobic drugs, and achieve the effect of avoiding side effects

Inactive Publication Date: 2016-05-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent only focuses on the research of linear PEGylated amphiphilic polymers that respond to the pH value of the external environment, and does not involve the application of other external response conditions such as redox
In addition, this injectable supramolecular hydrogel is only for hydrophobic cis-platinum (II) drugs in the selection of controlled release drugs, and it does not achieve simultaneous controlled release of hydrophilic and hydrophobic drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Under nitrogen protection, 2.0 g of polyethylene glycol with a number average molecular weight of 1000, 1.0 g of 2,2'-diselenidethanol, 0.8 g of 2,2-dimethylolpropionic acid and 0.1 g of bismuth laurate were added with Add 60ml of anhydrous THF to a dry three-necked round bottom flask with a stirrer, heat and stir to 50°C to fully dissolve the raw materials, then add 2.7g of isophorone diisocyanate dropwise into the flask, and continue to stir and react under the same conditions After 24h, an appropriate amount of methanol was added to continue the reaction for 1h. An appropriate amount of diethyl ether was added to the product to precipitate the reactant, redissolved with an appropriate amount of THF, and then purified with an appropriate amount of diethyl ether. The obtained product was dried under vacuum at 50°C for 24 hours to obtain a multi-block polyether polyurethane containing diselenium; 3.5 g of the obtained product and 1.5 g of indomethacin were added to 70 g...

Embodiment 2

[0033] Under nitrogen protection, 2.0 g of polyethylene glycol with a number average molecular weight of 1000, 1.0 g of 2,2'-diselenidethanol, 0.8 g of 2,2-dimethylolpropionic acid and 0.1 g of bismuth laurate were added with Add 60ml of anhydrous THF to a dry three-necked round bottom flask with a stirrer, heat and stir to 50°C to fully dissolve the raw materials, then add 2.7g of isophorone diisocyanate dropwise into the flask, and continue to stir and react under the same conditions After 24h, an appropriate amount of methanol was added to continue the reaction for 1h. An appropriate amount of diethyl ether was added to the product to precipitate the reactant, redissolved with an appropriate amount of THF, and then purified with an appropriate amount of diethyl ether. The obtained product was dried under vacuum at 50°C for 24 hours to obtain a multi-block polyether polyurethane containing diselenium; 3.5 g of the obtained product and 1.5 g of indomethacin were added to 70 g...

Embodiment 3

[0035] Under nitrogen protection, 2.0g of polyethylene glycol with a number average molecular weight of 1000, 1.0g2,2 ’ - Add diselenodiethanol, 0.8g 2,2-dimethylolpropionic acid and 0.1g bismuth laurate into a dry three-neck round bottom flask with a stirrer, add 60ml of anhydrous THF, heat and stir to 50°C to make the raw materials fully After dissolving, 2.7 g of isophorone diisocyanate was added dropwise into the flask, and after stirring and reacting for 24 h under the same conditions, an appropriate amount of methanol was added to continue the reaction for 1 h. An appropriate amount of diethyl ether was added to the product to precipitate the reactant, redissolved with an appropriate amount of THF, and then purified with an appropriate amount of diethyl ether. The obtained product was dried under vacuum at 50°C for 24 hours to obtain a multi-block polyether polyurethane containing diselenium; 3.5 g of the obtained product and 1.5 g of indomethacin were added to 70 g of d...

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Abstract

The invention relates to a preparation method of a pH and oxidation dual-responsive injectable supramolecular intelligent hydrogel. The hydrogel involved in the invention is composed of dual response method for preparing injectable supramolecular intelligent hydrogels. The hydrogel of the invention is composed of double-selenium containing multiblock polyether polyurethane, alpha-cyclodextrin, a loaded drug and water. The preparation process consists of: firstly introducing a double-selenium bond to a polyurethane main chain with good biocompatibility and pH sensitivity, then loading a hydrophobic drug at the same time of self-assembly into nanoparticles, finally introducing alpha-cyclodextrin molecules into the nanoparticle solution and letting the alpha-cyclodextrin molecules interpenetrate to a polyethylene glycol chain so as to obtain the supramolecular intelligent hydrogel, and loading the hydrophobic drug at the same time. The hydrogel has shear thinning property, and can be easily injected, is sensitive to pH and oxidation reduction environment, also can be oxidized and degraded through the introduced double-selenium bond, and has good application prospect in the biomedicine field as a common controlled-release carrier of hydrophilic and hydrophobic drugs.

Description

technical field [0001] The invention relates to the application of an injectable supramolecular hydrogel in the technical field of biomedical controlled release carriers, in particular to a preparation method of a dual-responsive injectable supramolecular intelligent hydrogel. Background technique [0002] The drug controlled release of hydrogel is to load the drug on the drug controlled release carrier gel, and the drug can permeate through the pores of the carrier gel in vivo or diffuse to the designated lesion through the gradual decomposition of the carrier gel. This permeation or diffusion effect is relatively slow, so that the loaded drug can be continuously released at a certain concentration, thereby prolonging the action time of the drug to fully exert the drug effect and avoiding high frequency of administration. [0003] Polymers with amphiphilic segments can self-assemble into colloidal particles with shell-core structure in aqueous solution. Among them, the hyd...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/48A61K47/34A61K31/405A61P35/00C08J3/075A61K31/352A61K31/704A61K31/513A61K31/4745A61K31/337
CPCA61K9/0019A61K31/337A61K31/352A61K31/405A61K31/4745A61K31/513A61K31/704A61K47/34C08J3/075C08J2207/10C08J2305/16C08J2475/08A61K2300/00
Inventor 金勇赖双权金泓宇李汉平孙小鹏
Owner SICHUAN UNIV
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