Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition for skin anti-ageing treatment

A technology of composition and extract, which is applied in the field of anti-aging treatment, can solve the problems of aggravating skin aging and wrinkles, and achieve the effect of avoiding the effect of estrogen and saving high costs

Inactive Publication Date: 2016-05-04
POLICHEM SA
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conversely, ethanol, as well as propanol or isopropanol, are not recommended for use in compositions targeting skin rejuvenation / wrinkling, as their lipid-solubilizing and dehydrating effects may exacerbate skin aging and wrinkling by thinning and hardening the skin the emergence of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for skin anti-ageing treatment
  • Composition for skin anti-ageing treatment
  • Composition for skin anti-ageing treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Formulations in gel form were prepared at the following weight percent (p.b.w.) (%) composition:

[0042]

[0043] *The term "carbomer" means acrylic acid homopolymer crosslinked with polyalkenyl polyether.

[0044] a) Dissolve the following ingredients in purified water (percentage by weight): Propylene Glycol 12% (percentage by weight) - Sodium Methylparaben 0.26% - Sodium Propylparaben 0.03% - Disodium EDTA 0.10% - Carbomer 0.75 %.

[0045] b) The following ingredients were dissolved in 5% ethanol (percentage by weight): vitamin E acetate 0.02%-phosphatidylcholine 0.85%-cholesterol 0.01%.

[0046] c) heating a) and b) separately at 60°C and combining them, homogenizing with a suitable turbo mixer; cooling the compound to 40°C and adding 1% (by weight) mother hop tincture under gentle stirring; 0.05% sodium hyaluronate premixed in a portion of the total purified water to form a homogeneous gel was added to the compound with stirring.

[0047] d) 0.20% imidazolid...

Embodiment 3

[0066] In order to test the different antioxidant activities of the composition according to Example 1 versus the comparative compositions 2-5 of Example 2, at different concentrations (0.500-0.016 mg / ml), in keratinocytes with and without test samples , after exposure to ultraviolet light A (UVA), tested against reactive oxygen species (ROS), cell survival after UVA stress was evaluated by the neutral red uptake (NRU) assay: cell survival assay using test samples with and without Human keratinocytes cultured in monolayer culture.

[0067] preparation

[0068]Human primary keratinocytes were obtained from pediatric foreskins during pre-planned routine surgery with approval from the ethics committee. The epidermis was isolated from the dermis by three static incubations and trypsinized to generate a single cell suspension.

[0069] In Dulbecco's modified Eagle's and Ham's F12 media (3:1) enriched with 10% fetal bovine serum (v / v) and specific enrichments (specific enrichmen...

Embodiment 4

[0081] In order to test the different collagen regeneration activities of the composition according to Example 1 versus the comparative compositions 2-5 of Example 2, the collagen synthesis in human skin fibroblasts treated with the test composition was evaluated in vitro at different concentrations ( 2.50%, 1.25%, 0.63%) for testing. Ex-novosynthesis of collagen was measured by colorimetric assay.

[0082] preparation

[0083] Test products are diluted in cell culture medium to achieve the final concentrations selected for testing. For preliminary cytotoxicity tests, products were tested at 20%, 10%, 5%, 2.50%, 1.25%, 0.63% and 0.31% (w / v). Based on toxicity data (IC 50 =6.79%, non-cytotoxic), select 3 different non-cytotoxic concentrations to continue the test. The concentrations chosen for potency testing were 2.50%, 1.25% and 0.63% (w / v). Cells were exposed to test products for 24 and 48 hours. At the end of each experimental time, neo-synthesis of extracellular ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention is directed to a composition comprising an extract of Humulus lupulus combined with hyaluronic acid and a C1-C4 alkanol, and to its use as an anti-ageing treatment for the skin of human being. For the use of the present invention, the new composition is administered topically.

Description

technical field [0001] The present invention relates to a kind of containing hyaluronic acid and C 1 -C 4 Compositions of alkanol-combined hops (Humulus lupulus) extracts and their use as anti-ageing treatment for human skin. For the use of the present invention, the novel compositions are applied topically. Background technique [0002] The aging process is a physiological consequence of cellular aging and an associated decreased ability to respond to stress. This irreversible process leads to several changes in the body: one of them involves the appearance of facial wrinkles. [0003] The skin is composed of two main layers: the outer layer, the epidermis, is composed mainly of keratinocytes and is responsible for forming a barrier against environmental damage (pathogens, heat, UV radiation and dehydration). The inner layer, the dermis, contains connective tissue made of structural components such as collagen (responsible for skin firmness), elastin fibers (responsible...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/73A61Q19/08A61K8/97
CPCA61K8/34A61K8/735A61Q19/08A61K8/042A61K8/9789A61P17/00A61P17/16A61P17/18A61K8/14A61K8/8141A61K2800/522A61K2800/524A61K2800/591
Inventor F·斯卡尔奇G·约布F·美兰
Owner POLICHEM SA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com