Resourceful treatment method for penicillin fungi residues

A technology of penicillin bacterial residue and treatment method, which is applied in the field of resource treatment of penicillin bacterial residue, can solve the problem of failure to finally realize penicillin bacterial residue reduction and harmlessness, failure to achieve penicillin reduction, and penicillin bacterial residue treatment. and other problems, to achieve the effect of reducing and harmless, conducive to subsequent disposal, and shortening the residence time

Active Publication Date: 2016-05-18
山东中科康源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to investigations, the amount of penicillin residue produced by each pharmaceutical company that produces penicillin drugs ranges from tens of thousands to hundreds of thousands of tons every year. The large amount has caused great difficulties in the treatment of penicillin residues.
The "National Hazardous Waste List" revised after 2008 defines it as hazardous waste and requires it to be incinerated. However, due to the high cost of incineration, it is easy to cause secondary pollution. The incineration of vitamins and growth factors is a great waste of resources. Therefore, the development of new technologies for the quantification and harmless treatment of penicillin residues has become an urgent problem for penicillin manufacturers.
[0003]Patent CN201310095896.1 discloses a method of treating penicillin residues by using thermal hydrolysis and anaerobic digestion process. 15-25 hours of solid-liquid separation, the treatment efficiency is not high, and there is still 0.5mg / kg of penicillin residue after treatment, and the complete reduction of penicillin cannot be achieved
Patent CN201510094833.3 discloses a pretreatment method using ultrasonic crushing technology to increase the anaerobic biogas production of penicillin slag. In this method, the dehydrated penicillin slag is mixed with distilled water for ultrasonic treatment, which requires pre-dehydration treatment and preparation of distilled water. The process operation is complicated, and this method only discloses an anaerobic pretreatment method, which fails to realize the reduction and harmlessness of penicillin residue

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  • Resourceful treatment method for penicillin fungi residues
  • Resourceful treatment method for penicillin fungi residues
  • Resourceful treatment method for penicillin fungi residues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Place the penicillin slag in a high-pressure steam kettle and feed steam at 1200kPa steamPress down, the steam temperature reaches 160°C, and keep it for 15 minutes. After the operation is completed, it is naturally cooled to room temperature and placed in a pretreatment tank. Add sodium hydroxide according to the ratio of penicillin slag: sodium hydroxide = 100:1.5 by weight. After mixing evenly, place it in an ultrasonic reactor for combined alkali and ultrasonic treatment. The frequency of ultrasonic treatment is 30kHz, and the sound energy density is 0.12W / mL. : Remaining sludge: Biological phosphorus: Ferrous chloride = 180:70:20:3 The ratio is evenly mixed, and the pH value is adjusted to 7-8 to obtain the prepared solution, which is placed in an anaerobic reaction tank for combined anaerobic digestion. 35% of the volume of the fermenter is inoculated with anaerobic digested sludge, the pH value is controlled at 6.5, and the organic load is 4kgCODm -3 d -1 , th...

Embodiment 2

[0048] Place the penicillin slag in a high-pressure steam kettle, feed steam, at 1500kPa steam Press down, the steam temperature reaches 180°C, and keep it for 10 minutes. After the operation is completed, it is naturally cooled to room temperature and placed in a pretreatment tank. Add sodium hydroxide in a ratio of penicillin slag: calcium hydroxide = 100:1.0 by weight. After mixing evenly, place it in an ultrasonic reactor for combined alkali and ultrasonic treatment. The frequency of ultrasonic treatment is 25kHz, and the sound energy density is 0.2W / mL. : Remaining sludge: Biological phosphorus: Ferrous sulfate = 200:85:35:6 Mix evenly, adjust the pH value to 7-8 to get the prepared liquid and put it in the anaerobic reaction tank for joint anaerobic digestion, according to the fermentation 40% of the tank volume is inoculated with anaerobic digested sludge, the pH value is controlled at 7.0, and the organic load is 3.5kgCODm -3 d -1 , the concentration of volatile org...

Embodiment 3

[0054] Place the penicillin slag in a high-pressure steam kettle and feed steam at 1100kPa steam Press down, the steam temperature reaches 150°C, and keep it for 2 minutes. After the operation is completed, it is naturally cooled to room temperature and placed in a pretreatment tank. Add sodium hydroxide according to the ratio of penicillin slag: sodium hydroxide = 100:1.8 by weight. After mixing evenly, place it in an ultrasonic reactor for combined alkali and ultrasonic treatment. The frequency of ultrasonic treatment is 30kHz, and the sound energy density is 1.2W / mL. : Remaining sludge: Biological phosphorus: Ferrous sulfate = 170:60:30:4 Mix evenly, adjust the pH value to 7-8 to get the prepared solution and place it in an anaerobic reaction tank for joint anaerobic digestion, according to the fermentation 30% of the tank volume is inoculated with anaerobic digested sludge, the pH value is controlled at 6.5, and the organic load is 4.0kgCODm -3 d -1 , the concentration ...

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Abstract

The invention provides a resourceful treatment method for penicillin fungi residues, wherein fungi residues produced during production of penicillin can be treated by adopting the steps of steam inactivation, enhanced pretreatment, mixing and blending, fungi residue blending, anaerobic co-digestion, concentrating and dewatering and the like. According to the invention, a treatment method low in energy consumption, high in efficiency and steady and reliable in effect is adopted, and drug residues in the penicillin fungi residues can be completely removed, thus realizing reduction and harmless treatment of the penicillin fungi residues.

Description

technical field [0001] The invention belongs to the field of solid waste treatment, and in particular relates to a method for recycling penicillin bacteria residues. Background technique [0002] Penicillin is the first antibiotic discovered in human history, and it is widely used. Its successful development has greatly enhanced the ability of humans to resist bacterial infections and led to the birth of the antibiotic family. Penicillin antibiotics are a general term for a large class of antibiotics in β-lactams. Since β-lactams act on the cell wall of bacteria, while humans only have cell membranes without cell walls, penicillin antibiotics have very little toxicity and are antibiotics with the largest chemotherapy index. . my country is a big penicillin producing country. The solid waste produced in the production process of penicillin is penicillin residue. Degradation products, flocculants, acidifiers, filter aids, residual organic solvents, residual antibiotics and m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B09B3/00B09B5/00
CPCB09B3/0075B09B5/00B09B3/45B09B3/00B09B2101/02
Inventor 刘树芹
Owner 山东中科康源生物科技有限公司
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