Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of a highly sensitive functionalized gold nanoparticle-doped fenarol molecularly imprinted electrochemical sensor

A gold nanoparticle, high-sensitivity technology, applied in the fields of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of inappropriate matching of functional monomers and template molecules, low sensitivity, poor cross-linking rigidity, etc.

Inactive Publication Date: 2018-04-03
GUANGXI UNIV FOR NATITIES
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of a highly sensitive functionalized gold nanoparticle-doped fenarol molecularly imprinted electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of Fenarol Molecularly Imprinted Electrochemical Sensor

[0017] To 10.0mL solvent ethanol, add 0.6mmol template molecule fenarol, 2.0mmol functional monomer aminotadalafil, 4.5mmol cross-linking agent 3-[2-[4-(6-fluoro-1 ,2-Benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxyl-2-methyl-4H-pyrido[1 , 2-a] pyrimidin-4-one palmitate, 0.2mmol initiator azobisisobutyronitrile and 0.0150g n-octyl thiol functionalized gold nanoparticles, each adding a chemical reagent ultrasonically dissolved for 5 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a high-sensitivity functionalized gold nanoparticle-doped chlormezanone MIECS (Molecular Imprinting Electrochemical Sensor). The preparation method is characterized by taking chlormezanone as a template molecule, aminotadalafil as a functional monomer, azodiisobutyronitrile as an initiator, octanethiol functionalized gold nanoparticles as a doping agent and 3-[2-[4-(6-fluorine-1,2-benzisoxazole-3-methyl)-1-piperidyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxyl-2-methyl-4H-pyridino[1,2-a]pyrimidine-4-ketopalmitate as a coupling agent, thus preparing the high-sensitivity octanethiol functionalized gold nanoparticle-doped chlormezanone MIECS. An analysis method is simple and practical, and the disadvantages of complexity, expensive price of equipment and low sensitivity of a previous analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a high-sensitivity functionalized gold nanoparticle-doped Fenarol molecularly imprinted electrochemical sensor. Background technique [0002] Chlormezanone is mainly used for the treatment of nervous tension, fear, psychoneuropathy, insomnia, muscle pain and spasm, and sore limbs. It has analgesic effect on rheumatic pain, arthritis, dysmenorrhea, angina pectoris, etc. This product also has anti-seasickness and anti-fatigue effects, but long-term or excessive use of such drugs may cause drug addiction problems or drowsiness, flushing, nausea, anorexia, drug rash, weakness, difficulty urinating, tremors, headaches, confusion and other side effects , and even have a fatal risk when the drug is stopped suddenly, so it is listed as a controlled drug by most countries in the world. [0003] The methods for determination of fenarol include ultra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 李浩余会成韦贻春雷福厚陈其锋谭学才
Owner GUANGXI UNIV FOR NATITIES