Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of dulcitol film-coated tablet and preparation method thereof

A technology of dulcitol and film coating, which is applied in the field of medicine to achieve quantitative accuracy, good clinical use value and social benefits, and the effect of maintaining the stability of drug quality

Active Publication Date: 2018-09-28
GUANGXI WUZHOU PHARMA GRP
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Pharmacological studies have shown that dehydrodulcitol (chemically named 1,2,5,6-dianhydrodulcitol) is a bis-epoxide of dibromodunglitol hydrogen bromide, and has cross-resistance with alkylating agents can be classified as alkylating agents, but its mechanism of action cannot be fully explained by this

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of dulcitol film-coated tablet and preparation method thereof
  • A kind of dulcitol film-coated tablet and preparation method thereof
  • A kind of dulcitol film-coated tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Tablet core layer prescription:

[0034]

[0035] Coating layer prescription: the weight ratio of Opadry II coating premix to purified water is 0.8:10;

[0036] Preparation of coating solution: Weigh 2.67g of Opadry II coating premix and slowly add it to 34ml of purified water being stirred. After the premix is ​​added, continue to stir for 45 minutes until it is completely dissolved, pass through a 100-mesh sieve, and set aside .

[0037] The present embodiment adopts the powder direct compression method, and the preparation process is carried out according to the following steps:

[0038] ① Pass the main drug through a 100-mesh sieve and the auxiliary materials through a 80-mesh sieve, weigh the main drug and each raw and auxiliary material according to the prescription amount, and set aside;

[0039] ② Take the weighed main ingredient, lactose, pregelatinized starch and microcrystalline cellulose and shake and mix, then add micropowder silica gel and mix well, f...

Embodiment 2

[0042] Tablet core layer prescription:

[0043]

[0044] Coating layer prescription: the weight ratio of Opadry II coating premix to purified water is 1.2:10;

[0045] Preparation of coating solution: Weigh 2.4g of Opadry II coating premix and slowly add it to 20ml of purified water being stirred. After the premix is ​​added, continue to stir for 45 minutes until it is completely dissolved, pass through an 80-mesh sieve, and set aside .

[0046] The present embodiment adopts the powder direct compression method, and the preparation process is carried out according to the following steps:

[0047] ① Pass the main drug through a 100-mesh sieve and the auxiliary materials through a 80-mesh sieve, weigh the main drug and each raw and auxiliary material according to the prescription amount, and set aside;

[0048] ② Take the weighed main ingredient, lactose, pregelatinized starch and microcrystalline cellulose and shake and mix, then add micropowder silica gel and mix well, fi...

Embodiment 3

[0051] Tablet core layer prescription:

[0052]

[0053] Coating layer prescription: the weight ratio of Opadry II coating premix to purified water is 1.0:10;

[0054] Preparation of coating solution: Weigh 2.43g of Opadry II coating premix and slowly add it to 25ml of purified water being stirred. After the premix is ​​added, continue to stir for 45 minutes until it is completely dissolved, pass through a 200-mesh sieve, and set aside .

[0055] The present embodiment adopts the powder direct compression method, and the preparation process is carried out according to the following steps:

[0056] ① Pass the main drug through a 100-mesh sieve and the auxiliary materials through a 80-mesh sieve, weigh the main drug and each raw and auxiliary material according to the prescription amount, and set aside;

[0057] ② Take the weighed main ingredient, lactose, pregelatinized starch and microcrystalline cellulose and shake and mix, then add micropowder silica gel and mix well, f...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a dianhydrodulcitol thin membrane coated tablet and a preparation method thereof. A dianhydrodulcitol raw material and common pharmaceutical adjuvants such as lactose, pregelatinized starch, microcrystalline cellulose, micropowder silica gel and magnesium stearate are mixed according to a certain proportion, and a compressed tablet is prepared and coated with a thin membrane coating prepared according to a certain process; the stability of the medicine can be effectively improved, and the absorption and bioavailability of the medicine are improved. The advantages of being simple in formulation and process and low in cost are achieved.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a pharmaceutical preparation capable of treating chronic myelogenous leukemia and a preparation method thereof, in particular to a film-coated tablet with anhydrodulcitol as an active ingredient and a preparation method thereof. Background technique [0002] Chronic Myelogenous Leukemia (CML) is a malignant tumor that affects the blood and bone marrow. The annual incidence of leukemia in the world is about 400,000, accounting for the sixth place in the incidence of various malignant tumors. It can be seen that leukemia is a serious disease. One of the malignant tumors that endanger human health. It is characterized by the production of a large number of immature white blood cells, which accumulate in the bone marrow and inhibit the normal hematopoiesis of the bone marrow; and can spread throughout the body through the blood, leading to anemia, easy bleeding, infection, and organ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K47/38A61K47/36A61K47/26A61K47/02A61K31/336A61P35/02
CPCA61K9/2009A61K9/2018A61K9/2054A61K9/2059A61K9/2866A61K31/336
Inventor 聂雪玫刘冠萍郑志远杨北妮
Owner GUANGXI WUZHOU PHARMA GRP