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Quaternary ammonium salt modified chitosan antibacterial agent and preparation method and application thereof

A technology of chitosan and quaternary ammonium salts, applied in the direction of botany equipment and methods, applications, biocides, etc., can solve the problems of low fiber permeability, low biological safety, poor antibacterial effect, etc., to improve separation efficiency, Good antibacterial performance and low cost effect

Active Publication Date: 2016-06-22
福建省隆丰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the technical problems of chitosan and existing modified chitosan with poor antibacterial effect, low biological safety and low fiber permeability, the invention provides a quaternary ammonium salt modified chitosan and its preparation method and application, The technical scheme of capping flexible polyethylene glycol with quaternary ammonium salt and grafting it to the amine group of chitosan improves the flexibility of chitosan structure, enhances the antibacterial performance of chitosan, and can penetrate deep It penetrates into the interior of biological materials such as textile fibers and dressings, which provides the possibility for the wide application of chitosan

Method used

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  • Quaternary ammonium salt modified chitosan antibacterial agent and preparation method and application thereof
  • Quaternary ammonium salt modified chitosan antibacterial agent and preparation method and application thereof
  • Quaternary ammonium salt modified chitosan antibacterial agent and preparation method and application thereof

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Embodiment 2

[0036] (1) Add 0.6mol epibromohydrin into a 250ml three-neck flask, add 0.3mol dimethyl n-octylamine dropwise to the solution while stirring, react at 40°C for 3 hours, and freeze the reaction solution in a -20°C freezer 5h, filter, and quickly recrystallize the filter cake twice with acetone, and finally exhaust the acetone under negative pressure to obtain intermediate A;

[0037] (2) Take 0.06mol of the intermediate product A of step (1) and 0.07mol of polyethylene glycol diamine (polyoxyethylene diamine) into tetrahydrofuran, react at 55°C for 10 hours, and then add 0.08mol of ethylene glycol to shrink Glycerol ether, continue to react for 10h, and the product is repeatedly precipitated twice with cold ether solution to obtain intermediate product B;

[0038](3) Take another flask, add B, chitosan and dimethylformamide (DMF) solution in sequence (the ratio of B, chitosan unit and DMF is 0.005mol: 0.1mol: 250ml), heat up to 2 Methylformamide was refluxed, reacted for 8 hou...

Embodiment 3

[0040] (1) Add 0.4mol epibromopropane to a 250ml three-neck flask, add 0.1mol dimethyl n-octylamine dropwise to the solution while stirring, react at 30°C for 6h, and freeze the reaction solution in a -20°C freezer 5h, filter, and quickly recrystallize the filter cake twice with acetone, and finally exhaust the acetone under negative pressure to obtain intermediate A;

[0041] (2) Take 0.05mol of the intermediate product A of step (1) and 0.06mol of polyethylene glycol diamine (polyoxyethylene diamine) into tetrahydrofuran, react at 60°C for 6 hours, and then add 0.065mol of ethylene glycol shrink Glycerol ether, continue to react for 6h, the product is repeatedly precipitated twice with cold ether solution, and the intermediate product B is obtained;

[0042] (3) Take another flask, add B, chitosan and dimethylformamide (DMF) solution in sequence (the ratio of B, chitosan unit and DMF is 0.015mol: 0.1mol: 150ml), and heat up to dimethylformamide (DMF) solution. Base formamid...

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Abstract

The invention provides quaternary ammonium salt modified chitosan and a preparation method and application thereof, and belongs to the technical field of biological materials. According to the adopted technical scheme, the quaternary ammonium salt modified chitosan antibacterial agent is obtained from quaternary ammonium salt modified polyethylene glycol and chitosan through a grafting reaction. A quaternary ammonium salt group in the structure of the quaternary ammonium salt modified polyethylene glycol is located at the end of the polyethylene glycol. The quaternary ammonium salt modified chitosan antibacterial agent has the advantages that the antibacterial performance and penetration performance are good, the raw material source is wide, the cost is low, the production is simple, industrial production is easy to achieve, and huge application potential is provided in the fields of clothing, spinning and the like.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a quaternary ammonium salt modified chitosan and a preparation method and application thereof. Background technique [0002] Due to its good biocompatibility, biodegradability, non-toxic side effects, and antibacterial and antiviral properties, chitosan is widely used in biological materials, medical care, drug carriers, medical and agricultural fungicides, cosmetics, food preservation, environmental protection, and veterinary drugs. And feed additives, and other fields have broad research and application prospects. The chemical name of chitosan is (1-4)-2-amino-2-dehydro-β-D-glucan, which is derived from chitin through deacetylation reaction. It is chitin (chemical name (1 ,4)-2-acetamide-2-deoxy-β-D-glucan) the most basic and important derivatives. Chitin is mainly found in animal shells such as shrimp, crabs, pupae, and insects, as well as in the cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08B37/08D06M15/03D06M15/53A01N43/16A01P1/00
CPCA01N43/16C08B37/003C08G81/00D06M15/03D06M15/53
Inventor 庄跃林陈江枫
Owner 福建省隆丰生物科技有限公司