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Novel rifamycin SV sodium salt production technology

A technology of rifamycin and production process, which is applied in the field of raw material drug production process, can solve the problems of no report, low yield, high impurity content, etc., and achieve the effect of ensuring quality, high product yield and improving purity

Active Publication Date: 2016-06-29
SHENYANG RES INST OF CHEM IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, it is of great significance to find a production process that is simple, produces less three wastes, consumes less raw materials, and overcomes the problems of high impurity content and low yield in the existing process for promoting the development of the industry.
[0007] The production process of the present invention is the first at home and abroad, and there is no report in domestic and foreign literature and patent retrieval

Method used

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  • Novel rifamycin SV sodium salt production technology
  • Novel rifamycin SV sodium salt production technology

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1) Extraction. Starting from the fermented liquid of the traditional process, put 100KG of fermented liquid into the reaction kettle, and pump the fermented liquid and 12.5KG of the W / O emulsion liquid film obtained in the emulsification tank into the extraction tank for extraction at 25°C to 30°C The time is 30 minutes.

[0032] The emulsion is prepared by mixing 30KG organic phase and 15KG internal water phase in a high-speed shear emulsifier at a speed of 4000 rpm to form a W / O emulsion liquid film; wherein the organic phase is a surfactant, a film solvent Composed with carrier, the inner water phase is 20% (m / m) sodium bicarbonate solution; the quality of sulfonated kerosene is 37.6KG, the quality of surfactant L-113A is 1.2KG, and the quality of N263 is 1.2KG.

[0033] 2) Primary separation: put the extracted mixed solution in the separation tank for 60 minutes to separate the mixed solution under gravity, the upper layer is the loaded emulsion, and the lower laye...

Embodiment 2

[0037] 1) Extraction. Taking the fermented liquid of the traditional process as the starting point, the fermented liquid and 20KG of the W / O emulsion liquid film obtained in the emulsification tank are pumped into the extraction device, and the extraction time is 45 minutes at 25°C to 30°C.

[0038] The emulsion is prepared by mixing 30KG organic phase and 15KG internal water phase in a high-speed shear emulsifier at a speed of 3500 rpm to form a W / O emulsion liquid film; wherein the organic phase is a surfactant, a film solvent Composed with carrier, the inner water phase is 15% (m / m) sodium hydroxide solution; the mass of n-hexane is 37.6KG, the mass of surfactant L-113B is 1.2KG, and the mass of TBP is 1.2KG.

[0039] 2) Primary separation: put the extracted mixed solution in the separation tank for 60 minutes to separate the mixed solution under gravity, the upper layer is the loaded emulsion, and the lower layer is the waste mother liquor; the upper layer enters the demul...

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Abstract

The invention relates to a bulk pharmaceutical chemical production technology, in particular to a novel rifamycin SV sodium salt production technology.A W / O emulsion liquid membrane is extracted from fermentation broth, and rifamycin SV sodium is directly generated.The content of the product obtained by means of the production technology is 90-97%, and water content is 2.6-5%.The technological process is short, three-waste output is low, raw material consumption is low, the yield of rifamycin SV sodium is effectively increased, and the problems of existing technologies that the technological process is long, impurity content is high and yield is low are solved.The novel rifamycin SV sodium salt production technology has great significance in promoting industrial development and has broad industrialized application prospects.

Description

technical field [0001] The invention relates to a production process of raw material medicine, in particular to a new production process of rifamycin SV sodium salt. Background technique [0002] Rifamycin SV sodium salt CAS registration number: 14897-39-3 Molecular formula: C37H46NNaO12, molecular weight 719.75, molecular structural formula: [0003] [0004] Physical and chemical properties: orange red or dark red crystalline powder. The melting point is 300°C (decomposition at 140°C). Soluble in methanol, ethanol, propanol, ethyl acetate, slightly soluble in water, petroleum ether, soluble in ether, bicarbonate solution. The aqueous solution is relatively stable and can be stored at room temperature for 3a. Odorless, bitter taste. It is a broad-spectrum antibiotic and can enter cells. It is a full-effect bactericidal drug with strong bactericidal power. Oral malabsorption, for injection only. It is mainly used for infections caused by Gram-positive bacteria such ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D498/08
CPCC07D498/08
Inventor 刘艳蒲爱军李鹏孙宇明张源
Owner SHENYANG RES INST OF CHEM IND
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