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Medicine composition with acetylcysteine and medical application of medicine composition

A technology of acetylcysteine ​​and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can solve the problems that have not been reported related to acetylcysteine, and achieve outstanding substantive Effect of characteristic, healing effect improvement

Inactive Publication Date: 2016-07-20
陈昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between acetylcysteine ​​and its pharmaceutical composition and acute liver failure

Method used

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  • Medicine composition with acetylcysteine and medical application of medicine composition
  • Medicine composition with acetylcysteine and medical application of medicine composition
  • Medicine composition with acetylcysteine and medical application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Separation method: (a) Grind Chickweed (2kg), extract with 80% ethanol under heat reflux (15L x 3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L x 3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 type macroporous resin to remove impurities from the ethyl acetate extract in the medium, first elute with 25% ethanol for 8 column volumes, then use 70% ethanol for 12 column volumes, collect 70% eluate, and depressurize Concentrate to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 85:1 (10 column volumes), 45:1 ( 8 column volumes), 25:1 (10 column volumes) and 15:1 (8 co...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] Wistar rats, body weight 170-200g, both male and female.

[0029] 1.2 Reagents and samples

[0030] Acetylcysteine ​​was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Galactosamine (GalN) was purchased from Chongqing Medical University, and Tang reagent was produced by Xiamen Shang Reagent Factory.

[0031] 1.3 Instruments

[0032] Automatic amino acid analyzer (Beckman company)

[0033] 1.4 Rat grouping and model preparation

[0034] Rats were randomly divided into 5 groups, 12 in each group, which were normal control group, model control group, acetylcysteine ​​group (64 mg·kg -1 ), compound (Ⅰ) group (64mg·kg -1 ), acetylcysteine ​​and compound (I) composition group [32mg·kg -1 Acetylcysteine+32mg·kg -1 Compound (I)]. At the beg...

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Abstract

The invention discloses a medicine composition with acetylcysteine and medical application of the medicine composition. The medicine composition with acetylcysteine contains clenbuterol hydrochloride and a natural product compound (I) which adopts a novel structure; when acetylcysteine and the compound (I) work independently, the effects of reducing serum transaminase, bilirubin and urea nitrogen contents of liver damaged animals can be achieved, jaundice and renal dysfunction are relieved, and the toxin content of plasma can be reduced; when acetylcysteine and the compound (I) are combined, the pharmacologic action is more obvious, and the medicine composition can be prepared into a medicine for treating acute liver failure; compared with the prior art, the medicine composition disclosed by the invention has outstanding substantive features and a remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of acetylcysteine, in particular to a pharmaceutical composition of acetylcysteine ​​and its application in acute liver failure. Background technique [0002] Acetylcysteine ​​is a mucolytic agent, and its molecular formula contains a sulfhydryl group (-SH), which can break the disulfide bond (-S-S-) in the polypeptide chain, reduce the viscosity of sputum, and make the sputum easy to discharge. It can not only dissolve white sputum It can also dissolve purulent phlegm, and is suitable for diseases that cause dyspnea and expectoration due to a large amount of sticky phlegm. It is used for patients with difficulty in expectoration after operation, acute and chronic bronchitis, bronchiectasis, pneumonia, tuberculosis, emphysema, etc. causing thick sputum and difficulty in expectoration. It is also used in the treatment of idiopathic interstitial lung. [0003] So far, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00A61K31/585A61K31/198A61P1/16
CPCC07J73/003A61K31/198A61K31/585
Inventor 陈昊
Owner 陈昊
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