Quick-drying surgical hand disinfection solution and preparation method thereof

Abstract

The invention discloses a quick-drying surgical hand disinfection solution and a preparation method of the quick-drying surgical hand disinfection solution. The quick-drying surgical hand disinfection solution mainly comprises bactericidal compositions and purified water, wherein the bactericidal compositions comprise the following raw materials which are taken as constituents: organosilicon quaternary ammonium salt, Chlorhexidine gluconate, ethanol and glycerol. The preparation method of the quick-drying surgical hand disinfection solution comprises the following steps: adding ethanol in a mixing tank, then adding the organosilicon quaternary ammonium salt, Chlorhexidine gluconate and glycerol and simultaneously stirring to be completely dissolved, then adding purified water to be diluted, and adding a pH (Potential of Hydrogen) regulator to adjust the pH value to 5.5 to 7.5 to obtain the quick-drying surgical hand disinfection solution. The disinfection solution disclosed by the invention solves the defects of slow bactericidal effect of Chlorhexidine gluconate and weak sterilization of ethanol, reaches quick disinfection and sterilization and a long-lasting antibacterial effect, can effectively protect human skin by adding glycerol, has small skin irritation, no harm to human health, convenient use, easily obtained raw materials, simple formula, suitability for industrial production and capability of being used for surgical hand washing disinfection, hygiene hand washing disinfection and daily hand disinfection.

Description

technical field [0001] The invention relates to the field of preoperative hand disinfection in medical institutions, in particular to a quick-drying and sterilizing surgical hand sanitizer. Background technique [0002] At present, the hand disinfection done by medical staff in the hospital to prevent nosocomial infection is mainly based on the compound formula of two disinfectants or the disinfectant solution of a single disinfectant component, which lacks long-term antibacterial function and cannot guarantee the period of 4-6 hours for major operations The long-lasting antibacterial, poses a risk of infection. Organosilicon quaternary ammonium salt is a new type of cationic surfactant, which has a strong and durable antibacterial effect in terms of fungicides. It is used as a long-lasting antibacterial agent in textiles, leather, metals and coatings. Its main role in daily chemicals is as Foam and viscosity are adjusted in shampoos. Chlorhexidine gluconate is a mild bigu...

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Problems solved by technology

[0003] Publication number is that the Chinese patent of CN103704241B discloses chlorhexidine gluconate alcohol disinfectant, manufacturing method and disinfection cotton swab, cotton sheet respectively; The point is that the main proportion of its disinfectant is composed of chlorhexidine gluconate and ethanol. Ethanol does not have long-lasting bactericidal activity and has no bactericidal effect after volatilization. However, the bactericidal effect of single chlorhexidine gluconate is not good and cannot continue to sterilize. Generally not used in surgery

The Chinese patent with the publication number CN102429604A discloses a portable hand sanitizing wet tissue paper. The wet tissue liquid mainly contains chlorhexidine gluconate and ethanol, and also adds aloe vera extract, paraben During the absorption process of non-woven fabrics, such as methyl esters and essences, due to the small amount of added disinfectants, the objects to be disinfected cannot be completely included, and the initial effect of sterilization is still slow, and they cannot be completely disinfected

Publication No. 200510045294.0 discloses a preparation method of organosilicon quaternary ammonium salt bactericide, wherein although organosilicon quaternary ammonium salt is mixed with ethanol, it is mainly used on textiles, because organosilicon quaternary ammonium salt is easy to fall off and has high toxicity, Long-term enrichment on the surface of the human body is prone to lesions; the Chinese patent with the publication number CN101380316B discloses a multifunctional external antibacterial agent and a preparation method, using benzalkonium bromide, benzalkonium chloride, organic silicon quaternary ammonium salt, ethanol and water together, It works by spraying and is mainly used for surface disinfection of objects. It is inconvenient to use in hospitals such as surgery.

[0004] To sum up, the current disinfectants added with chlorhexidine gluconate or ethanol cannot last for a long time, and the single effect or the combination of the two cannot achieve the long-term bactericidal effect

At the same time, as a medical treatment, because medical staff need to wash their hands for a long time, the current hand sanitizers are not as effective as long-term sterilization, and contain irritation, which hurts the skin of medical staff, so they are not suitable for medical use.

Although organosilicon quaternary ammonium salt is used as an antibacterial agent and has long-lasting antibacterial properties, it is mainly used for surface disinfection of objects, and has not been used in hand sanitizers at present.

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