The invention provides an isolated weaning breeding method for Guizhou native piglets. The method comprises the following steps of (1) feeding feed A within first 3 days after weaning of he piglets, wherein the feed A is prepared from fermented soybean meal, plasma protein powder, puffed corn, glucose, fish meal, crowndaisy chrysanthemum fermented dry powder, rhizoma phragmitis powder, citric acid, compound amino acid, compound vitamin, organic selenium 0, ferrous fumarate and edible salt; and (2) from the fourth day to the fiftieth day after weaning, feeding feed B, wherein the feed B is prepared from extruded soybeans, extruded corn, wheat bran, fermented soybean meal, fish meal, calcium hydrophosphate, hawthorn fruit powder, grape seed fermented dry powder, compound amino acid, compoundmicroorganisms, choline chloride, organic selenium, ferrous fumarate and edible salt. According to the breeding method, the daily gain of Guizhou native Congjiang xiang pigs after weaning can be remarkably improved, the occurrence rate of diarrhea is remarkably reduced, and the Congjiang xiang pigs fed according to the method have excellent meat quality.