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145 results about "Acetyl-coenzyme A carboxylase" patented technology
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Acetyl-CoA carboxylase inhibitors
Acetyl Coenzyme A Carboxylase inhibitors, pharmaceutical compositions containing such compounds and the use of such compounds to treat for example, Metabolic Syndrome including atherosclerosis, diabetes and obesity.
Owner:PFIZER INC +1
ACC inhibitors and uses thereof
Owner:NIMBUS DISCOVERY INC +1
Acc inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:NIMBUS DISCOVERY INC +1
ACETYL CoA CARBOXYLASE (ACCase) GENE FROM JATROPHA CURAS
InactiveUS20090205079A1High oil contentFacilitates detection and selectionSugar derivativesOther foreign material introduction processesJatrophaGene
The present invention provides methods for increasing oil content in Jatropha Curcas L. plants. The invention further provides the cDNA and protein sequences of Jatropha acetyl CoA carboxylase (ACCase) and methods for cloning and expressing the Jatropha ACCase gene to produce transgenic plants with increased oil content.
Owner:RELIANCE LIFE SCI PVT
ACETYL CoA CARBOXYLASE INHIBITORS
The present invention relates to acetyl coenzyme-A carboxylase (“ACC”) inhibiting compounds of the formulawherein the variables are as defined herein. In particular, the present invention relates to ACC1 and / or ACC2 inhibitors, compositions of matter, kits and articles of manufacture comprising these compounds, methods for inhibiting ACC1 and / or ACC2, and methods of making the inhibitors.
Owner:TAKEDA PHARMA CO LTD
Modified photosynthetic microorganisms for producing lipids
ActiveUS20110250659A1Reduce the amount requiredIncrease volumeHydrolasesUnicellular algaePhylum CyanobacteriaLipid formation
This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that contain one or more exogenous genes encoding a phospholipase and / or thioesterase, which are capable of producing an increased amount of lipids and / or fatty acids. This disclosure also describes genetically modified photosynthetic microorganisms that contain one or more exogenous genes encoding a diacyglycerol acyltransferase, a phosphatidate phosphatase, and / or an acetyl-CoA carboxylase, which are capable of producing increased amounts of fatty acids and / or synthesizing triglycerides, as well as photosynthetic microorganism comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism.
Owner:LUMEN BIOSCI INC
Herbicide composition used for rape field contg. propyl-ester nitorfen and iso-propyl-ester nitrofen
ActiveCN1513321ABroad herbicidal spectrumStrong targetingBiocideDead animal preservationMetolachlorBenzylamine
A composite herbicide for rape field contains the pyrimidine benzylamine kind of herbicide, at least one of quizalofop-ethyl, fluazifop-p-butyl, haloxyfop, fenoxaprop and sethoxydim, acetochlor, alachlor, napropamide, ehaprochlor, metolachlor, ethamet sulfuron and benazolin. Its advantages are high effect, broad spectrum, low dosage and high safety.
Owner:ZHEJIANG RES INST OF CHEM IND CO LTD +1
N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors
The invention provides a compound of Formula (I)or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.
Owner:PFIZER INC
N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
The invention provides a compound of Formula (I)or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.
Owner:PFIZER INC
Modified Photosynthetic Microorganisms With Reduced Glycogen and Their Use in Producing Carbon-Based Products
This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen as compared to a wild type Cyanobacterium, and which are capable of producing an increased amount of lipids and / or fatty acids. In certain embodiments, the genetically modified photosynthetic microorganisms also contain one or more exogenous genes encoding a diacyglycerol acyltransferase, a phosphatidate phosphatase, and / or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of lipids or fatty acids and / or synthesizing triglycerides.
Owner:LUMEN BIOSCI INC
Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
Owner:J P LAWSON CONSULTING LLC +2
Herbicide-Tolerant Plants
The present invention provides herbicide-tolerant plants. The present invention also provides methods for controlling the growth of weeds by applying an herbicide to which herbicide-tolerant plants of the invention are tolerant. Plants of the invention may express an acetyl-Coenzyme A carboxylase enzyme that is tolerant to the action of acetyl-Coenzyme A carboxylase enzyme inhibitors.
Owner:BASF AGROCHEMICAL PROD BV
Modified photosynthetic microorganisms for producing triglycerides
This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacylglycerol acyltransferase, a phosphatidate phosphatase, and / or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and / or synthesizing triglycerides.
Owner:LUMEN BIOSCI INC
Ester acc inhibitors and uses thereof
The present invention provides ester compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:SCHRODINGER INC +1
Method for producing eriodictyol by reforming escherichia coli in metabolic engineering
ActiveCN103865864AReduce manufacturing costLow costBacteriaMicroorganism based processesAcetyl Coenzyme A SynthetaseTyrosine
The invention discloses a method for producing eriodictyol by reforming escherichia coli in metabolic engineering, belonging to the field of metabolic engineering. The step of transforming naringenin into the eriodictyol is successfully realized through a gene engineering technology by carrying out fusion expression on two genes, namely a flavone 3' hydroxylase gene tF3'H with a membrane binding sequence cut and a P450 reductase gene tCPR, in escherichia coli. A tyrosine ammonia lyase gene TAL from R.glutinis, 4-coumarate:coenzyme A ligase gene 4CL from P.crispum, a chalcone synthase gene CHS from P.hybrida and a chalcone isomerase gene CHI from M.sativa are simultaneously expressed to realize that naringenin is directly produced through tyrosine, so that an engineered strain for directly producing eriodictyol through tyrosine is established. According to the method, in order to increase the output of eriodictyol, an acetokinase ackA gene contained in an escherichia coli genome is removed by being knocked, an acetyl coenzyme A synthetase gene acs and an acetyl coenzyme A carboxylase gene ACC are excessively expressed, and the output of eriodictyol can finally reach 106.7 mg / L.
Owner:JIANGNAN UNIV
Pyrazole acc inhibitors and uses thereof
The present invention provides pyrazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:NIMBUS DISCOVERY INC +1
Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof
The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
Owner:J P LAWSON CONSULTING LLC +2
Method for biologically synthesizing poly-3-hydroxypropionic acid
InactiveCN103898034AWide variety of sourcesSimple production processBacteriaMicroorganism based processesEscherichia coli3-Hydroxypropionic acid
The invention provides a recombinant escherichia coli strain, a preparation method of the recombinant escherichia coli strain and a method for biologically synthesizing poly-3-hydroxypropionic acid from acetyl coenzyme A. The method comprises the following steps: with glucose or glycerin and the like as carbon sources, commonly over-expressing endogenous or exogenous acetyl coenzyme A carboxylase genes (acc) and propionyl coenzyme A synthetase genes (prpE) as well as exogenous malony coenzyme A reductase genes (mcr) and polyhydroxyalkanoate synthetase genes (phaC) in proper host cells (such as escherichia coli), and degrading intermediate products by virtue of glucose so as to biologically synthesize the poly-3-hydroxypropionic acid, wherein acetyl coenzyme A is finally obtained from simple starting materials such as the glucose and the like.
Owner:QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
Acc inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:NIMBUS DISCOVERY INC
Acetyl-CoA carboxylase inhibitors
InactiveUS6979741B2Ease of preparation and detectabilityGood metabolic stabilityOrganic chemistryMetabolism disorderMedicineMetabolic syndrome
Owner:PFIZER INC +1
Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
Owner:BOEHRINGER INGELHEIM INT GMBH
Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products
This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen as compared to a wild type Cyanobacterium, and which are capable of producing an increased amount of lipids and / or fatty acids. In certain embodiments, the genetically modified photosynthetic microorganisms also contain one or more exogenous genes encoding a diacyglycerol acyltransferase, a phosphatidate phosphatase, and / or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of lipids or fatty acids and / or synthesizing triglycerides.
Owner:LUMEN BIOSCI INC
Bicyclic compounds as ACC inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Owner:NIMBUS DISCOVERY INC
ACETYL-CoA CARBOXYLASE HERBICIDE RESISTANT SORGHUM
The present invention provides for compositions and methods for producing crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants, plant tissues and plant seeds that contain altered acetyl-CoA carboxylase (ACC) genes and proteins that are resistant to inhibition by herbicides that normally inhibit the activity of the ACC protein.
Owner:KANSAS STATE UNIV RES FOUND
Modified photosynthetic microorganisms for producing triglycerides
This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacylglycerol acyltransferase, a phosphatidate phosphatase, and / or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and / or synthesizing triglycerides.
Owner:LUMEN BIOSCI INC
Rice ACCase mutant gene and application thereof in herbicide resistance of plants
The invention discloses a rice ACCase mutant gene and an application thereof in herbicide resistance of plants. The amino acid sequence of the encoding protein of the ACCase mutant gene has the following mutation: the 1731st siteor / and 2276th site of the amino acid sequence corresponding to the wild type rice ACCase is subjected to mutation. The ACCase mutant gene is introduced into herbicide-sensitive rice genome by a transgenic method and is expressed; and receiver plants can have resistance to acetyl-CoA carboxylase inhibitor herbicide. The ACCase mutant gene can be widely applied to the breeding of plants with the herbicide resistance.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Fragmentation chytrid mutagenesis method and variant produced by fragmentation chytrid mutagenesis method
The invention relates to a new fragmentation chytrid variant. Especially, the invention relates to a fragmentation chytrid variant with improved DHA (docosahexaenoic acid) content and / or rapid growth speed and a method for producing DHA by utilizing the variant. Besides, the invention also relates to a method for producing the variant, comprising the steps of carrying out mutagenesis on fragmentation chytrid by adopting ultraviolet rays and screening a strain with rapid growth speed and high DHA content under selective pressure of an inhibitor (such as quizalofop) for fat synthesis key enzyme (acetyl coenzyme A carboxylase).
Owner:法国罗凯特兄弟公司
Acc inhibitors and uses thereof
The present invention provides for compounds of formula I as acetyl-CoA carboxylase (ACC) inhibitors. The ACC inhibitors are useful for the prevention or treatment of metabolic syndrome, including obesity, dyslipidemia and hyperlipidemia in humans. The inhibitor compounds are also capable of inhibiting the ACC enzyme found in plants, parasites and bacteria.
Owner:GILEAD APOLLO LLC +1
Insecticidal and acaricidal composition containing acetyl coenzyme A inhibitor insecticide
ActiveCN104663668ASynergistic effect is obviousImprove the effect of prevention and controlBiocideAnimal repellantsChemical compositionActive component
The invention belongs to the field of insecticides, and relates to an insecticidal and acaricidal composition containing an acetyl coenzyme A inhibitor insecticide. The composition contains an active component A and an active component B, a weight part ratio of the component A to the component B is 1:99-99:1, the active component A is a compound I represented by a structural formula shown in the invention, and the active component B is selected from acetyl coenzyme A carboxylase inhibitor insecticides / acaricides. The composition has the advantages of obvious synergy and resistance delaying, and can be used for controlling various insects.
Owner:SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD
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