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40 results about "Acyl-CoA carboxylase" patented technology

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Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT).

ACC inhibitors and uses thereof

ActiveUS8969557B2Organic active ingredientsBiocideAcyl-CoA carboxylaseStereochemistry

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

ACC inhibitors and uses thereof

ACC inhibitors and uses thereof

ACC inhibitors and uses thereof

Owner:NIMBUS DISCOVERY INC +1

Acc inhibitors and uses thereof

ActiveUS20130123231A1Organic active ingredientsBiocideAcyl-CoA carboxylaseStereochemistry

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Acc inhibitors and uses thereof

Acc inhibitors and uses thereof

Acc inhibitors and uses thereof

Owner:NIMBUS DISCOVERY INC +1

ACETYL CoA CARBOXYLASE (ACCase) GENE FROM JATROPHA CURAS

InactiveUS20090205079A1High oil contentFacilitates detection and selectionSugar derivativesOther foreign material introduction processesJatrophaGene

The present invention provides methods for increasing oil content in Jatropha Curcas L. plants. The invention further provides the cDNA and protein sequences of Jatropha acetyl CoA carboxylase (ACCase) and methods for cloning and expressing the Jatropha ACCase gene to produce transgenic plants with increased oil content.

ACETYL CoA CARBOXYLASE (ACCase) GENE FROM JATROPHA CURAS

ACETYL CoA CARBOXYLASE (ACCase) GENE FROM JATROPHA CURAS

ACETYL CoA CARBOXYLASE (ACCase) GENE FROM JATROPHA CURAS

Owner:RELIANCE LIFE SCI PVT

N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

ActiveUS20110111046A1BiocideOrganic chemistryDiseaseEnzyme

The invention provides a compound of Formula (I)or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

Owner:PFIZER INC

N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors

ActiveUS8288405B2BiocideOrganic chemistryDiseaseAcyl-CoA carboxylase

The invention provides a compound of Formula (I)or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors

N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors

N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors

Owner:PFIZER INC

Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

ActiveUS20110028390A1Delay progressBiocideOrganic chemistryAcyl-CoA carboxylaseEnzyme inhibitor

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.

Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors

Owner:PFIZER INC

Acc inhibitors and uses thereof

InactiveUS20170145028A1Organic active ingredientsBiocideChemistryMedicinal chemistry

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Acc inhibitors and uses thereof

Acc inhibitors and uses thereof

Acc inhibitors and uses thereof

Owner:GILEAD APOLLO LLC

Acc inhibitors and uses thereof

ActiveUS20160108060A1Antibacterial agentsBiocideStereochemistryAcetyl-CoA carboxylase

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Acc inhibitors and uses thereof

Acc inhibitors and uses thereof

Acc inhibitors and uses thereof

Owner:NIMBUS DISCOVERY INC

Pyrrolidine derivatives, pharmaceutical compositions and uses thereof

ActiveUS20140343083A1BiocideOrganic chemistryPyrrolidineObesity

Pyrrolidine derivatives which are inhibitors of acetyl-CoA carboxylase(s) and their use in the treatment of obesity and type-2 diabetes. An exemplary compound is 2-(4-(1-[5-Chloro-6-(2-hydroxy-2-methyl-propoxy)-pyrimidin-4-yl]-(R)-pyrrolidin-3-yloxy)-phenyl)-N-cyclopropyl-propionamide.

Pyrrolidine derivatives, pharmaceutical compositions and uses thereof

Pyrrolidine derivatives, pharmaceutical compositions and uses thereof

Pyrrolidine derivatives, pharmaceutical compositions and uses thereof

Owner:BOEHRINGER INGELHEIM INT GMBH

Herbicide composition and application method thereof

ActiveCN109864068ASynergistic effect is obviousReduce dosageBiocideAnimal repellantsActive componentGlyphosate

The invention relates to a herbicide composition and an application method thereof. The composition comprises an active component A and an active component B, wherein the component A is selected froma compound represented by a following general formula, and the component B is one selected from acetyl-CoA carboxylase (ACC) inhibitor type herbicides. The herbicide composition disclosed by the invention is particularly suitable for preventing and removing weeds with tolerance or resistance to organophosphorus herbicides, especially glyphosate.

Herbicide composition and application method thereof

Herbicide composition and application method thereof

Herbicide composition and application method thereof

Owner:SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD

Enzymatic systems for carbon fixation and methods of generating same

ActiveUS9410131B2HydrolasesTransferasesPyruvate synthesisAcetaldehyde

A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.

Enzymatic systems for carbon fixation and methods of generating same

Enzymatic systems for carbon fixation and methods of generating same

Enzymatic systems for carbon fixation and methods of generating same

Owner:YEDA RES & DEV CO LTD

Acetyl-CoA Carboxylase Herbicide Resistant Sorghum

InactiveUS20100115663A1BiocideMicrobiological testing/measurementBiotechnologyPlant tissue

The present invention provides for compositions and methods for producing crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants, plant tissues and plant seeds that contain altered acetyl-CoA carboxylase (ACC) genes and proteins that are resistant to inhibition by herbicides that normally inhibit the activity of the ACC protein.

Acetyl-CoA Carboxylase Herbicide Resistant Sorghum

Owner:KANSAS STATE UNIV RES FOUND

Ester acc inhibitors and uses thereof

ActiveUS20200010478A1Antibacterial agentsBiocideEnzyme Inhibitor AgentCarboxysome

The present invention provides ester compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Ester acc inhibitors and uses thereof

Ester acc inhibitors and uses thereof

Ester acc inhibitors and uses thereof

Owner:NIMBUS DISCOVERY INC +1

ACC inhibitors and uses thereof

ActiveUS10208044B2Antibacterial agentsBiocideSecondary hyperlipidemiaMedicine

The present invention provides for compounds of formula I as acetyl-CoA carboxylase (ACC) inhibitors. The ACC inhibitors are useful for the prevention or treatment of metabolic syndrome, including obesity, dyslipidemia and hyperlipidemia in humans. The inhibitor compounds are also capable of inhibiting the ACC enzyme found in plants, parasites and bacteria.

ACC inhibitors and uses thereof

ACC inhibitors and uses thereof

ACC inhibitors and uses thereof

Owner:GILEAD APOLLO LLC +1

Method for improving fermentation level of salinomycin by increasing supply of precursors

ActiveCN104357506AIncrease supplyImprove fermentation yieldBacteriaMicroorganism based processesBiotechnologyAcyl-CoA carboxylase

The invention discloses a method for improving the fermentation level of salinomycin by increasing supply of precursors. The method comprises the following steps: doubling acetyl coA carboxylase genes from streptomyces coelicolor, methyl malonyl coA mutase genes from streptomyces albus DSMZ41398 and crotonoyl coA reductase genes from the streptomyces albus DSMZ41398 on the chromosomes of the streptomyces albus DSMZ41398 through an integrating vector pSET152 respectively to increase supply of three precursors required for synthesizing salinomycin so as to increase the salinomycin yield. According to the method, the final fermentation yield of engineering strain salinomycin is increased by 260% and the shake flask level of a lab reaches 2 g / L.

Method for improving fermentation level of salinomycin by increasing supply of precursors

Method for improving fermentation level of salinomycin by increasing supply of precursors

Method for improving fermentation level of salinomycin by increasing supply of precursors

Owner:SHANGHAI JIAO TONG UNIV

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

InactiveUS20160220557A1Organic active ingredientsDermatological disorderDepressantEnzyme inhibitor

The present invention relates to methods of treating and / or preventing acne in patients comprising the step of administering to patients in need of such treatment a therapeutically effective amount of an ACC inhibitor or a pharmaceutically acceptable salt thereof.

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Owner:PFIZER INC

Acetyl CoA carboxylase inhibitors

InactiveUS7981904B2BiocideOrganic chemistryAcyl-CoA carboxylaseStereochemistry

The present invention relates to acetyl coenzyme-A carboxylase (“ACC”) inhibiting compounds of the formulawherein the variables are as defined herein. In particular, the present invention relates to ACC1 and / or ACC2 inhibitors, compositions of matter, kits and articles of manufacture comprising these compounds, methods for inhibiting ACC1 and / or ACC2, and methods of making the inhibitors.

Acetyl CoA carboxylase inhibitors

Acetyl CoA carboxylase inhibitors

Acetyl CoA carboxylase inhibitors

Owner:TAKEDA PHARMA CO LTD

Triazole acc inhibitors and uses thereof

ActiveUS20200017519A1Antibacterial agentsBiocideEnzyme Inhibitor AgentBiochemistry

The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Triazole acc inhibitors and uses thereof

Triazole acc inhibitors and uses thereof

Triazole acc inhibitors and uses thereof

Owner:GILEAD APOLLO LLC +1

Modified plants with increased oil content

InactiveUS20140230091A1High oil contentAvoid inhibitionLiquid hydrocarbon mixture productionImmunoglobulinsAcyl carrier proteinCoenzyme A biosynthesis

Methods and means are provided to increase the oil content of plants, particularly oleaginous plants by preventing feedback inhibition by 18:1-Coenzyme A or 18:1-Acyl Carrier Protein of the acetyl CoA-carboxylase enzyme in cells of these plants in various manners.

Modified plants with increased oil content

Modified plants with increased oil content

Modified plants with increased oil content

Owner:BROOKHAVEN SCI ASSOCS

Carboxyltransferase domain of acetyl-CoA carboxylase

InactiveUS7884189B2Peptide/protein ingredientsPeptide preparation methodsX-rayBiology

The present invention provides compositions and crystals of the carboxyltransferase (CT) domain (the C-terminal ˜90 kDa fragment) of various acetyl-CoA carboxylase (ACC) proteins, including yeast, mouse and human ACCs. Further, the present invention provides methods for identifying and designing compounds that can modulate ACC activity. These methods are based, in part, on the X-ray crystallographic structures of the CT domain of yeast ACC, either alone or bound to acetyl-CoA or a CT inhibitor, such as haloxyfop or diclofop or CP-640186. Thus, the present invention relates to the crystal structures of the carboxyltransferase (“CT”) domain of acetyl-CoA carboxylase (“ACC”), and to the use of these structures in the design of anti-obesity compounds, anti-diabetes compounds, antibiotic compounds, herbicide compounds, and in the design of herbicide resistant plants.

Carboxyltransferase domain of acetyl-CoA carboxylase

Carboxyltransferase domain of acetyl-CoA carboxylase

Carboxyltransferase domain of acetyl-CoA carboxylase

Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK

Compound used as ACC (Acetyl CoA Carboxylase) inhibitor and application thereof

ActiveCN109305976AOrganic active ingredientsOrganic chemistryDiseaseFibrosis

The invention belongs to the field of medical chemistry and relates to a compound used as an ACC (Acetyl CoA Carboxylase) inhibitor and application thereof. Specifically, the invention provides a compound shown as a formula I or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, a preparation method of the compounds, a pharmaceutical composition containing the compounds and application of the compounds or the pharmaceutical composition to treatment and / or prevention ACC expression related diseases, such as fibrotic diseases, metabolic diseases, cancers or tissue proliferation diseases. The compound provided by the invention has very good inhibition activity on ACC and is very hopefully prepared into a treatment medicine for the fibrotic diseases, the metabolic diseases, the cancers or the tissue proliferation diseases. The formula I is shown in the description.

Compound used as ACC (Acetyl CoA Carboxylase) inhibitor and application thereof

Compound used as ACC (Acetyl CoA Carboxylase) inhibitor and application thereof

Compound used as ACC (Acetyl CoA Carboxylase) inhibitor and application thereof

Owner:NANJING SANHOME PHARMACEUTICAL CO LTD

Agent for promoting energy consumption

InactiveUS20120010285A1Improve athletic abilityHigh energyOrganic active ingredientsBiocideChlorogenic acidEnergy expenditure

Provision of a pharmaceutical product, a quasi-drug, a food, a beverage, a pet food, a feed, and others which are highly safe, have excellent action of promoting energy consumption, promoting fat burning, promoting carbohydrate burning, or improving an effect of exercise, and which are effective for the prevention or amelioration of obesity or metabolic syndrome or the improvement of motor functions.An agent for promoting energy consumption, an agent for promoting fat burning, an agent for promoting carbohydrate burning, an agent for improving an effect of exercise, an agent for improving motor functions, an agent for inhibiting acetyl-CoA carboxylase 2, and an agent for inhibiting pyruvate dehydrogenase kinase 4 containing chlorogenic acids or salts thereof as an active ingredient.

Agent for promoting energy consumption

Agent for promoting energy consumption

Agent for promoting energy consumption

Owner:KAO CORP

ACC inhibitors and uses thereof

InactiveUS10179793B2Organic active ingredientsBiocideAcyl-CoA carboxylaseStereochemistry

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

ACC inhibitors and uses thereof

ACC inhibitors and uses thereof

ACC inhibitors and uses thereof

Owner:GILEAD APOLLO LLC

Enzymatic systems for carbon fixation and methods of generating same

ActiveUS20120301947A1Bioreactor/fermenter combinationsBiological substance pretreatmentsPyruvate synthesisAcetaldehyde

A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.

Enzymatic systems for carbon fixation and methods of generating same

Enzymatic systems for carbon fixation and methods of generating same

Enzymatic systems for carbon fixation and methods of generating same

Owner:YEDA RES & DEV CO LTD

Recombinant bacteria for synthesizing succinic acid from fixed amount of carbon dioxide, as well as construction method and application of recombinant bacteria

ActiveCN106967662AAvoid excessive dependenceIncrease profitBacteriaTransferasesEscherichia coliPropionyl-CoA carboxylase

The invention provides recombinant bacteria for synthesizing succinic acid from a fixed amount of carbon dioxide, as well as a construction method and application of the recombinant bacteria, and belongs to the field of gene engineering and fermentation engineering. A recombinant bacteria host is escherichia coli, which can express a gene accADBC of acetyl-CoA carboxylase, a gene mcr of malonyl CoA reductase, a gene pcs of propionyl CoA synthase, a gene pcc of propionyl CoA carboxylase, a gene mcE of methylmalonyl-CoA isomerase, a gene mcM of methylmalonyl-CoA mutase and a gene sucCD of succinyl-coenzyme A synthase. According to the construction method, recombinant carriers pACYCDuet-accADBC-pcs and pETDuet-mcr-pcc-sucCD-mcEM are transformed into a host cell. The recombinant bacteria constructed through the construction method can adopt glucose serving as a unique carbon source to synthesize the succinic acid, and fermentation is performed for 48 hours, thus obtaining the succinic acid with the concentration of 6.06 g / L.

Recombinant bacteria for synthesizing succinic acid from fixed amount of carbon dioxide, as well as construction method and application of recombinant bacteria

Recombinant bacteria for synthesizing succinic acid from fixed amount of carbon dioxide, as well as construction method and application of recombinant bacteria

Recombinant bacteria for synthesizing succinic acid from fixed amount of carbon dioxide, as well as construction method and application of recombinant bacteria

Owner:QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI

RECOMBINANT BIOTIN CARBOXYLASE DOMAINS FOR IDENTIFICATION OF ACETYL CoA CARBOXYLASE INHIBITORS

InactiveUS20090011433A1LigasesBiological testingFungicideBiotin

A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain is described. A nucleic acid that encodes the peptide described above and a recombinant host cell that contains the nucleic acid and expresses the encoded peptide is also described. A method of identifying Acetyl CoA carboxylase inhibitors, fungicides, herbicides and pharmaceuticals is also described herein.

RECOMBINANT BIOTIN CARBOXYLASE DOMAINS FOR IDENTIFICATION OF ACETYL CoA CARBOXYLASE INHIBITORS

RECOMBINANT BIOTIN CARBOXYLASE DOMAINS FOR IDENTIFICATION OF ACETYL CoA CARBOXYLASE INHIBITORS

RECOMBINANT BIOTIN CARBOXYLASE DOMAINS FOR IDENTIFICATION OF ACETYL CoA CARBOXYLASE INHIBITORS

Owner:CROPSOLUTION

N1/N2-lactam acetyl-CoA carboxylase inhibitors

ActiveUS8859773B2BiocideOrganic chemistryAcyl-CoA carboxylaseEnzyme inhibitor

The invention provides a compound of Formula (I)or a pharmaceutically acceptable salt thereof; whereinG isR1, R2 and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

N1/N2-lactam acetyl-CoA carboxylase inhibitors

N1/N2-lactam acetyl-CoA carboxylase inhibitors

N1/N2-lactam acetyl-CoA carboxylase inhibitors

Owner:PFIZER INC

Inhibitors of Acetyl-CoA Carboxylase for Treatment of Neuronal Hypometabolism

InactiveUS20110003767A1Lower metabolismLoss of cognitive functionBiocideNervous disorderHuntingtons choreaMild cognitive impairment (MCI)

This invention relates to methods of using inhibitors of the enzyme acetyl-CoA carboxylase (ACC) for the treatment, prevention, inhibition or alleviation of diseases associated with neuronal hypometabolism and / or loss of cognitive function caused by reduced neuronal metabolism such as, for example, Age Associated Memory Impairment (AAMI), Mild Cognitive Impairment (MCI), Alzheimer's disease, Parkinson's disease, Friedreich's Ataxia (FRDA), GLUT1-deficient Epilepsy, Leprechaunism and Rabson-Mendenhall Syndrome, Coronary Arterial Bypass Graft (CABG) dementia, anesthesia induced memory loss, Huntington's disease and many others.

Inhibitors of Acetyl-CoA Carboxylase for Treatment of Neuronal Hypometabolism

Inhibitors of Acetyl-CoA Carboxylase for Treatment of Neuronal Hypometabolism

Inhibitors of Acetyl-CoA Carboxylase for Treatment of Neuronal Hypometabolism

Owner:CERECIN INC +1

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

InactiveCN105530940AOrganic active ingredientsDermatological disorderAcyl-CoA carboxylasePharmacology

The present invention relates to methods of treating and / or preventing acne in patients comprising the step of administering to patients in need of such treatment a therapeutically effective amount of an ACC inhibitor or a pharmaceutically acceptable salt thereof.

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris

Owner:PFIZER INC

Method for using nanoparticles as nucleation agents for the crystallization of proteins

ActiveUS20170101436A1Increase opportunitiesHigh success ratePolycrystalline material growthFrom normal temperature solutionsProtein structureBovine serum albumin

The present invention relates to a method for the crystallization of protein using nanoparticles as nucleation agents. Precisely, the inventors performed the crystallization of such proteins as Bacillus subtilis YesR, chicken egg white lysozyme, bovine serum albumin, Alicyclobacillus acidocaldarius acetyl-CoA carboxylase, and Listeria monocytogenes hypothetical protein which have his-tag at amino terminal by using gold nanoparticles in diverse sizes and shapes in the presence of Ni2+ ions. As a result, it was confirmed that the chance of successful crystallization was higher with the gold nanoparticles than without the gold nanoparticles and the various crystallization conditions were successfully screened. Therefore, the method for inducing nucleation of the invention can be advantageously used for the disclosure of protein structure by increasing the chance of successful crystallization of protein.

Method for using nanoparticles as nucleation agents for the crystallization of proteins

Method for using nanoparticles as nucleation agents for the crystallization of proteins

Method for using nanoparticles as nucleation agents for the crystallization of proteins

Owner:UNIV OF SEOUL IND COOP FOUND

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