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Rhizoma atractylodis macrocephaiae extract and application thereof in resisting methicillin-resistant staphylococcus aureus

A technology of Atractylodes Rhizoma Atractylodes Extract and methicillin resistance, applied in the field of Atractylodes Rhizoma Atractylodes Extract and its application in anti-Methicillin-resistant Staphylococcus aureus, can solve the problems of reduced sensitivity to vancomycin and teicoplanin, Achieve the effect of restraining bacterial drug resistance, high safety, and enhancing resistance

Active Publication Date: 2016-08-10
祁门县益群生态农业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially in recent years, the sensitivity to glycopeptide antibiotics vancomycin and teicoplanin has decreased, so there is an urgent need to develop drugs that can replace antibiotics

Method used

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  • Rhizoma atractylodis macrocephaiae extract and application thereof in resisting methicillin-resistant staphylococcus aureus
  • Rhizoma atractylodis macrocephaiae extract and application thereof in resisting methicillin-resistant staphylococcus aureus
  • Rhizoma atractylodis macrocephaiae extract and application thereof in resisting methicillin-resistant staphylococcus aureus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of Atractylodes Rhizome Extract

[0048] (1) Take 300g of Atractylodes macrocephala medicinal material or decoction pieces (provided by Hefei Minyuan Pharmacy) and crush them through a 60-mesh sieve, wash them with double distilled water at 25°C, centrifuge to obtain a solid, add double distilled water to soak for 12 hours, and then centrifuge, The obtained solid was dried in an incubator, the temperature was controlled at 45°C, and Atractylodes macrocephala powder was obtained;

[0049] (2) At room temperature, add 3 times the volume of hydrogen peroxide aqueous solution and 0.1% sodium pyrophosphate to the Atractylodes Rhizome powder and stir for 0.5 h, then filter and extract the processed Atractylodes Rhizome powder;

[0050] (3) Place the Atractylodes Rhizome treatment powder obtained in step (2) in a fume hood to irradiate with an ultraviolet lamp, continuously irradiate 10 times, each time for 2 minutes, and turn over the Atractylodes Rhizome treatmen...

Embodiment 2

[0056] Preparation of Atractylodes Rhizome Extract

[0057] (1) Take 300g of Atractylodes macrocephala medicinal material or decoction pieces (provided by Hefei Minyuan Pharmacy) and crush them through a 60-mesh sieve, wash them with double distilled water at 25°C, centrifuge to obtain a solid, add double distilled water for 8 hours, and centrifuge again. The obtained solid was dried in an incubator, the temperature was controlled at 40°C, and Atractylodes macrocephala powder was obtained;

[0058] (2) At room temperature, add 3 times the volume of hydrogen peroxide aqueous solution and 0.2% sodium pyrophosphate to the Atractylodes Rhizome powder, stir for 1 hour, and then extract the processed Atractylodes Rhizome powder by suction filtration;

[0059] (3) Place the Atractylodes Rhizome treatment powder obtained in step (2) in a fume hood to irradiate with an ultraviolet lamp, continuously irradiate 10 times, each time for 2 minutes, and turn over the Atractylodes Rhizome tre...

Embodiment 3

[0065] Preparation of Atractylodes Rhizome Extract

[0066] (1) Take 300g of Atractylodes macrocephala medicinal material or decoction pieces (provided by Hefei Minyuan Pharmacy) and crush them through a 60-mesh sieve, wash them with double distilled water at 25°C, centrifuge to obtain a solid, add double distilled water for 8 hours, and centrifuge again. The obtained solid was dried in an incubator, the temperature was controlled at 40°C, and Atractylodes macrocephala powder was obtained;

[0067] (2) At room temperature, add 3 times the volume of hydrogen peroxide aqueous solution and 0.2% sodium pyrophosphate to the Atractylodes Rhizome powder, stir for 1 hour, and then extract the processed Atractylodes Rhizome powder by suction filtration;

[0068] (3) Place the Atractylodes Rhizome treatment powder obtained in step (2) in a fume hood to irradiate with an ultraviolet lamp, continuously irradiate 10 times, each time for 2 minutes, and turn over the Atractylodes Rhizome tre...

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Abstract

The invention relates to rhizoma atractylodis macrocephaiae extract and an application thereof in resisting methicillin-resistant staphylococcus aureus, and relates to the medical field of traditional Chinese medicines. A preparation method for the extract comprises the following steps: taking, crushing and cleaning a rhizoma atractylodis macrocephaiae medicinal material or decoction, soaking, centrifuging, drying, adding a hydrogen peroxide aqueous solution to stir, filtering rhizoma atractylodis macrocephaiae treated powder, drying, adding ascorbic acid into the rhizoma atractylodis macrocephaiae treated powder, carrying out ultrasonic microwave extraction by use of an alcohol solution, refluxing and extracting, carrying out suction filtration, recycling filtrate, carrying out micro-filtration clarification through a 0.2-mum micro-filtration membrane, and concentrating the filtrate under reduced pressure. According to the in-vivo and in-vitro experiments, the rhizoma atractylodis macrocephaiae extract can be independently used for methicillin-resistant staphylococcus aureus, and also can be used for a sensitizer of antibiotics of the methicillin-resistant staphylococcus aureus.

Description

technical field [0001] The invention relates to the medical field of traditional Chinese medicine, in particular to an extract of Atractylodes Rhizoma Atractylodes Rhizome and its application in resisting methicillin-resistant Staphylococcus aureus. Background technique [0002] Baizhu is the dry rhizome of Atractylodes macrophylla. Atractylodes macrocephala contains polysaccharides, atractylodes ketone, atractylodes lactone, volatile oil, amino acids and resins, etc., which have certain pharmacological effects on regulating gastrointestinal motility, regulating immunity, anti-tumor, anti-oxidation, and delaying aging. Extracts from non-polar parts of Atractylodes Rhizoma Atractylodes Rhizome, including volatile oil, have strong biological activity, and are currently mainly used to make anti-tumor drugs or health products, and there are few reports on antibacterial treatment. [0003] The invention application with the application number 201510770416.6 discloses "Atractylod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A61P31/02
CPCA61K36/284A61K2236/13A61K2236/17A61K2236/333A61K2236/53
Inventor 胥振国蔡玉华刘修树范高福王凤华方丽波袁星向敏黄鹤春宫斌
Owner 祁门县益群生态农业有限公司
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