Hydroxyproline fermentation production technology

Abstract

The invention belongs to the technical field of separation and extraction of amino acids, and concretely relates to a hydroxyproline fermentation production technology. A technology for separating hydroxyproline from a special self-fermentation liquid is created through adopting a multi-stage series membrane separation technology and an electrodialysis technology in order to form the brand new hydroxyproline fermentation production technology. The hydroxyproline fermentation production technology can realize zero discharge of waste residues and wastewater in the hydroxyproline fermentation production process, thoroughly and radically solves the environment pollution problem in the hydroxyproline fermentation production process, improves the total yield of hydroxyproline to 70% or above, greatly improves the quality of the hydroxyproline product, and allows the hydroxyproline content of the hydroxyproline product to reach 99% or above.

Description

technical field

[0001] The invention relates to the technical field of separation and extraction of amino acids, in particular to a hydroxyproline fermentation production process. Background technique

[0002] Hydroxyproline (Hyp) is an imino acid, which is the product of L-proline hydroxylation, and its molecular formula is C 5 h 9 NO 3 . Hydroxyproline is white flaky crystal or crystalline powder, slightly sweet, with a melting point of 274°C, easily soluble in water and slightly soluble in ethanol. According to the position of hydroxylation of hydroxyproline, it can be divided into 3-hydroxyproline (3-Hyp) or 4-hydroxyproline (4-Hyp). Because hydroxyproline has two asymmetric carbon atoms, there are 4 stereoisomers. Trans-4-hydroxyproline is more common in nature. Trans-4-hydroxyproline was first found in animal collagen protein.

[0003] Trans-4-hydroxyproline is widely used in medicine, chemical industry, animal feed, nutrition and beauty industry, etc.

[0004] ...