Method for synthesizing ketone compounds by continuous cyclic catalytic reaction

A ketone compound and catalytic reaction technology, which is applied in the field of continuous cycle catalytic reaction to synthesize ketone compounds, can solve the problems of insurmountability, long reaction cycle, high reaction equipment, etc., and achieve the goal of reducing loss, shortening synthesis reaction time and improving catalytic efficiency Effect

Inactive Publication Date: 2016-08-17
能特科技(石首)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Although the rhodium-catalyzed reaction has its advantages, there are many insurmountable problems in the disclosed technology
For example, the amount of metal rhodium input at one time is large, the reaction cycle is long, the loss of metal rhodium, high requirements for reaction equipment, large investment, high energy consumption, etc. are difficult to solve in industrial applications.

Method used

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  • Method for synthesizing ketone compounds by continuous cyclic catalytic reaction
  • Method for synthesizing ketone compounds by continuous cyclic catalytic reaction
  • Method for synthesizing ketone compounds by continuous cyclic catalytic reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] see figure 1

[0041] 1. Parameter setting and input: Input various values ​​of reaction temperature, reaction time, reaction pressure, heat exchange temperature and pressure, opening and closing time of pressure control valve and catalyst discharge valve, liquid flow rate value of flow rate controller into the inside the console;

[0042] 2. Input of raw material liquid and catalyst: feed the farnesene raw material liquid with a content of 97% through the liquid inlet pipe through the advection pump, and set the flow rate by the flow rate controller. The liquid enters at a flow rate of 0.4L / min, and the content is 95 The raw material liquid of % methyl acetoacetate passes through the advection pump through the liquid inlet pipe, and the flow rate is set by the flow rate controller. , triphenylphosphine trisulphonic acid sodium salt, water and methanol, the catalyst raw material liquid is passed through the advection pump through the catalyst liquid inlet pipe, and th...

Embodiment 2

[0051] see figure 1

[0052] 1. Parameter setting and input: Input various values ​​of reaction temperature, reaction pressure, heat exchange temperature and pressure, opening and closing time of pressure control valve and catalyst discharge valve, liquid flow rate value of flow rate controller into the operation console ;

[0053] 2. Input of raw material liquid and catalyst: feed the farnesene raw material liquid with a content of 95% through the liquid inlet pipe through the advection pump, and set the flow rate by the flow rate controller. The raw material liquid of ethyl acetoacetate is passed through the advection pump through the liquid inlet pipe, and the flow rate is set by the flow rate controller. The catalyst raw material liquid composed of phosphine bis-sulfonic acid sodium salt, water and ethanol is passed through the catalyst inlet pipe through the advection pump, and the flow rate is set by the flow rate controller. The liquid enters at a flow rate of 1.7L / mi...

Embodiment 3

[0062] see figure 1

[0063] 1. Parameter setting and input: Input various values ​​of reaction temperature, reaction pressure, heat exchange temperature and pressure, opening and closing time of pressure control valve and catalyst discharge valve, liquid flow rate value of flow rate controller into the operation console ;

[0064] 2. Input of raw material liquid and catalyst: feed the farnesene raw material liquid with a content of 98% through the liquid inlet pipe through the advection pump, and set the flow rate by the flow rate controller. The liquid enters at a flow rate of 0.7 L / min, and the content is 98 The % propyl acetoacetate raw material liquid is passed through the advection pump through the liquid inlet pipe, and the flow velocity is set by the flow velocity controller. The catalyst raw material liquid composed of phenylphosphine monoisosulfonic acid sodium salt, water and propanol is passed through the advection pump through the catalyst liquid inlet pipe, and...

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Abstract

The invention provides a method for synthesizing ketone compounds through continuous circular catalytic reaction. The method is carried out according to the following steps: 1. Parameter setting and input; 2. Input of raw material liquid and catalyst; 3. Mixed liquid and heating and pressurizing catalytic synthesis reaction; 4. Lowering temperature and lowering pressure treatment; . Delivery of farnesyl acetone products; 7. Recycling of catalysts. The method changes the method of stepwise reaction synthesis of farnesyl acetone into one step reaction synthesis, and can reduce the content of rhodium element in the organic phase. The method makes the catalyst in the reaction be recycled repeatedly, and greatly reduces the precious metal rhodium The loss improves the catalytic efficiency and shortens the synthesis reaction time, and the method can not only produce farnesyl acetone, but also produce condensate intermediates.

Description

technical field [0001] The invention relates to the field of chemical synthesis, in particular to a method for synthesizing ketone compounds through continuous circulation catalytic reaction. Background technique [0002] Isophytol is an intermediate for the production of vitamin E and vitamin K, and the current global demand exceeds 100,000 tons. The molecular structure of isophytol is a linear diterpenoid eicosallyl alcohol formed by connecting four isoprenes head to tail. Its molecular structure is [0003] [0004] The chemical synthesis of isophytol has a common feature, that is, using suitable starting materials to gradually extend the carbon chain through the chemical reaction or rearrangement reaction of carbon-carbon bond formation, and finally synthesize 20-carbon isophytol. For example, isophytol can be synthesized by adding two carbon atoms to the hexahydrofarnesyl acetone obtained by the full hydrogenation of farnesyl acetone, and then hydrogenating after Gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/68C07C49/203
CPCY02P20/584C07C45/68
Inventor 代齐敏郑由浒陈强姚亮周显亮刘鹏
Owner 能特科技(石首)有限公司
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