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A kind of preparation method of galloyl glucose

A technology of galloyl and glucose, applied in the field of preparation of galloyl glucose, can solve the problems of complex chemical structure, cumbersome separation process, long experimental period, etc., and achieves the effects of large amount of monomer preparation, good separation effect and shortening of separation time.

Active Publication Date: 2018-10-26
INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Such compounds have complex chemical structures, poor solubility, and contain multiple phenolic hydroxyl groups. Conventional column chromatography separation and purification will produce strong adsorption on the surface of solid media, resulting in low recovery and low purity, and separation The process is cumbersome and the experiment cycle is long
It has been reported in the literature (Ren Yulin, et al.J Med Chem.2006,49(9):2829) that this type of compound can be prepared by chemical synthesis, but its application is greatly restricted due to shortcomings such as complex process and high cost. limit

Method used

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  • A kind of preparation method of galloyl glucose
  • A kind of preparation method of galloyl glucose
  • A kind of preparation method of galloyl glucose

Examples

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Effect test

Embodiment 1

[0064] A preparation method of galloyl glucose, comprising the steps of:

[0065] (1) preparation of Juglans catalpa bark extract:

[0066] Get the dried walnut catalpa bark and pulverize through a pulverizer. Weigh 1 kg of the bark powder of Chinese catalpa, add 10 times the weight of ethanol aqueous solution with a volume fraction of 70%, reflux for extraction for 3 hours, and filter; repeat the above steps for the filter residue, and then extract 2 times, combine the filtrates, and concentrate under reduced pressure to extract shape, to obtain Juglans catalpa bark extract 124g.

[0067] (2) Degreasing and drying of the bark extract of Chinese catalpa:

[0068] Get 100g of the Chinese catalpa bark extract obtained in step (1), add appropriate amount of water to make 800ml suspension, put it into a separatory funnel, add petroleum ether 800mL to extract, repeat 3 times, to get rid of fat-soluble Composition, the aqueous layer solution was collected, concentrated by rotary ...

Embodiment 2

[0087] A preparation method of galloyl glucose, comprising the steps of:

[0088] (1) prepare walnut exocarp extract:

[0089] Take 1 kg of dry and pulverized walnut exocarp powder, add 8 times the weight of ethanol solution with a volume fraction of 80%, reflux for extraction for 2 hours, and filter; repeat the above steps for the filter residue, and then extract twice, combine the filtrates, and concentrate under reduced pressure To extract shape, obtain 110g of walnut exocarp extract.

[0090] (2) Degreasing and drying of walnut exocarp extract:

[0091] Take 100g of walnut exocarp extract obtained in step (1), add appropriate amount of water to make 800ml suspension, put it into a separatory funnel, add petroleum ether 800mL to extract, repeat 3 times, to remove fat-soluble components , collecting the aqueous layer solution, concentrating by rotary evaporation under reduced pressure until it has no alcohol taste, and obtaining the degreased walnut exocarp extract, which ...

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Abstract

The invention provides a preparation method of galloyl glucose. The preparation method of the galloyl glucose of the present invention comprises the steps of crushing, crude extraction, extraction, enrichment by high-speed countercurrent chromatography, purification, collection and drying. Compared with traditional column chromatography, the preparation method of galloyl glucose is time-saving, economical, fast and efficient. According to actual needs, the chemical components of galloyl glucose can be obtained, and further purified to obtain 4-6 kinds of monogalloyl glucose. body compound. The method provides a new plant source for the mass preparation of galloylglucose compounds, and at the same time provides an experimental basis for the development of related medicines.

Description

technical field [0001] The invention relates to the technical field of separation of natural products, in particular to a preparation method of galloyl glucose. Background technique [0002] Galloylglucose is a kind of hydrolyzable tannin monomer compound, which widely exists in plants and has various biological activities. Among them, pentagalloyl glucose has anti-oxidation, anti-tumor, anti-virus, anti-inflammatory, hypoglycemic, hypolipidemic and other activities [Li Huichen, Hu Wei, Ding Jingyong. Research progress on the anti-tumor effect of pentagalloyl glucose[J]. Modern Oncology Medicine, 2014, (9): 1672-4992.], [1,2,3,4,6-penta-O-galloyl-B-D-glucose as the preparation of anti-influenza drugs] (authorized announcement number CN101618043B ) reported the application value of pentagalloyl glucose in anti-influenza. Invention patent [Use of the effective part of gallaceae in the preparation of anti-ulcerative colitis medicine] (authorized announcement number CN10186235...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H13/08C07H1/06C07H1/08
CPCC07H1/06C07H1/08C07H13/08
Inventor 张玉伟孙印石李珊珊
Owner INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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