Double-layer polysiloxane super-molecular elastomer dressing for chronic skin wounds and preparation method thereof

A technology of supramolecular elastomer and polysiloxane, which is applied in the field of synthetic polymer biomaterials, can solve the problems of aggravating the pain of patients and increasing the workload of nursing care, and achieve the goals of resisting bacterial infection, accelerating wound healing, and good water absorption. Effect

Active Publication Date: 2016-09-28
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the clinical nursing practice of chronic refractory skin wounds in my country, gauze dressings and foam dressings are still the main ones at present. The former is difficult to provide a good moist healing environment for the

Method used

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  • Double-layer polysiloxane super-molecular elastomer dressing for chronic skin wounds and preparation method thereof
  • Double-layer polysiloxane super-molecular elastomer dressing for chronic skin wounds and preparation method thereof
  • Double-layer polysiloxane super-molecular elastomer dressing for chronic skin wounds and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: A kind of preparation of skin wound dressing (DLF-1) with double-layer structure based on polysiloxane supramolecular elastomer:

[0055] (1) Synthesis of terminal hydrogen polysiloxane (PHMS): 300 g of 1,1,3,3-tetramethyldisiloxane and octamethylcyclotetra Siloxane by molar ratio HMM:D 4 = 1:15 feed, then add the equivalent of D 4 Mass 2% concentration is 80wt% sulfuric acid. After stirring the reaction at room temperature for 20 h, separate the lower sulfuric acid phase with a separatory funnel, and use excess NaHCO 3 The residual sulfuric acid in the product was neutralized, and the crude product obtained after vacuum filtration was distilled under reduced pressure at 160° C. for 3 h to obtain the purified PHMS.

[0056] (2) Ester-terminated polysiloxane (PDMS-tBMA 2 ) synthesis: in the reaction kettle equipped with reflux condenser, nitrogen protection device and constant pressure dropping funnel, add PHMS, start stirring and pass N 2 , after 5 mi...

Embodiment 2

[0062] Embodiment 2: A kind of preparation of skin wound dressing (DLF-2) with double-layer structure based on polysiloxane supramolecular elastomer:

[0063] (1) Synthesis of terminal hydrogen polysiloxane (PHMS): 300 g of 1,1,3,3-tetramethyldisiloxane and octamethylcyclotetra Siloxane by molar ratio HMM:D 4 = 1:10 feed, then add the equivalent of D 4 Mass 3% concentration is 86wt% sulfuric acid. After stirring the reaction at room temperature for 20 h, separate the lower sulfuric acid phase with a separatory funnel, and use excess NaHCO 3 The residual sulfuric acid in the product was neutralized, and the crude product obtained after vacuum filtration was distilled under reduced pressure at 160° C. for 3 h to obtain the purified PHMS.

[0064] (2) Ester-terminated polysiloxane (PDMS-tBMA 2 ) synthesis: in the reaction kettle equipped with reflux condenser, nitrogen protection device and constant pressure dropping funnel, add PHMS, start stirring and pass N 2 , after 5 mi...

Embodiment 3

[0070] Embodiment 3: A kind of preparation of the skin wound dressing (DLF-3) that has double-layer structure based on polysiloxane supramolecular elastomer:

[0071] (1) Synthesis of terminal hydrogen polysiloxane (PHMS): 300 g of 1,1,3,3-tetramethyldisiloxane and octamethylcyclotetra Siloxane by molar ratio HMM:D 4 = 1:5 feed, then add the equivalent of D 4 Mass 4% concentration is 90wt% sulfuric acid. After stirring the reaction at room temperature for 20 h, separate the lower sulfuric acid phase with a separatory funnel, and use excess NaHCO 3 The residual sulfuric acid in the product was neutralized, and the crude product obtained after vacuum filtration was distilled under reduced pressure at 160° C. for 3 h to obtain the purified PHMS.

[0072] (2) Ester-terminated polysiloxane (PDMS-tBMA 2 ) synthesis: in the reaction kettle equipped with reflux condenser, nitrogen protection device and constant pressure dropping funnel, add PHMS, start stirring and pass N 2 , aft...

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Abstract

The invention discloses a double-layer polysiloxane super-molecular elastomer dressing for chronic skin wounds and a preparation method thereof. The method comprises the following steps that carboxyl-terminated polysiloxane reacts with a mono-bifunctionality primary amino compound and a bifunctionality primary amino compound successively, and siloxane oligomers are obtained; the siloxane oligomers react with isocyanate, and polysiloxane super-molecular elastomers serving as a base material and as a viscous layer respectively; the polysiloxane super-molecular elastomer serving as the viscous layer is dissolved and coated on the polysiloxane super-molecular elastomer serving as the base material, and the polysiloxane super-molecular elastomer dressing with a double-layer structure is obtained after solvent is evaporated. The thin film dressing has good air permeability and water absorption, the thin film base material has good elasticity and low viscosity, the thin film viscous layer shows good viscosity, and when the base material and the viscous layer are used as the dressing for the chronic wounds, growing and renewing of wounded tissues are promoted, and healing of the wounds is accelerated. According to the method, polysiloxane is adopted as the raw material, cytotoxicity and skin irritation do not exist, and the biocompatibility is good.

Description

technical field [0001] The invention belongs to the technical field of synthetic macromolecule biomaterials, and in particular relates to a double-layer polysiloxane supramolecular elastomer dressing for chronic skin wounds and its preparation. Background technique [0002] Chronic skin wounds, such as skin ulcers, pressure sores, diabetic foot, etc., have always been one of the clinical problems because they are common in the elderly or diabetic patients with poor physiological functions. In 1962, Winter published the "Moist Wound Healing Theory" in Nature, which gave people a breakthrough understanding of the wound healing process. Studies have found that various cells, enzymes, and growth factors on the wound are less active under dry conditions, but greatly increase their biological activity in a humid environment, which can promote the growth of granulation tissue and help wound healing. What's more, a warm, moist healing environment didn't increase the chance of wound...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/42C08G83/00
CPCA61L15/26A61L15/42A61L2400/16C08G83/008C08L87/00
Inventor 张安强犹阳黄炜妍马一媛林雅铃
Owner SOUTH CHINA UNIV OF TECH
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