Glycyrrhiza flavonoid dispersible tablet and preparation method and application thereof

A technology of licorice flavonoids and dispersible tablets is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of improving bioavailability, good uniformity and fast absorption

Inactive Publication Date: 2016-10-12
惠州市九惠制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to prepare the active ingredients in licorice into dispersible tablets and apply them to the treatment of gastric ulcer and duodenal ulcer to quickly exert curative effect is a relatively new research topic in this field, and there are still few in the prior art. mentioned

Method used

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  • Glycyrrhiza flavonoid dispersible tablet and preparation method and application thereof
  • Glycyrrhiza flavonoid dispersible tablet and preparation method and application thereof
  • Glycyrrhiza flavonoid dispersible tablet and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] According to the prescription of above-mentioned dispersible tablet, take licorice flavone, microcrystalline cellulose, crospovidone and croscarmellose sodium, mix well, obtain mixed fine powder; Get 5%-8% povidone solution and Phospholipids are dissolved in 10-20 parts of ethanol to prepare a binder; the binder is added to the mixed fine powder for granulation, and then croscarmellose sodium and magnesium stearate are added after granulation, and pressed Tablet, namely sample 1 of licorice flavone dispersible tablet.

Embodiment 2

[0037]According to the prescription of the above-mentioned dispersible tablets, take licorice flavonoids, microcrystalline cellulose and crospovidone, mix well to obtain a mixed fine powder; take 5%-8% povidone solution and phospholipids and dissolve them in 10-20 parts of ethanol , prepare the binder; add the binder to the mixed fine powder for granulation, add croscarmellose sodium and magnesium stearate after granulation, and press into tablets to obtain licorice flavonoid dispersible tablets The sample 2.

Embodiment 3

[0039] According to the prescription of the above-mentioned dispersible tablet, take licorice flavonoids, microcrystalline cellulose, crospovidone and croscarmellose sodium, mix well to obtain mixed fine powder; take 5%-8% povidone solution Dissolve phospholipids in 10-20 parts of ethanol to prepare an adhesive; add the adhesive to the mixed fine powder for granulation, add magnesium stearate after granulation, and press into tablets to obtain licorice flavonoid dispersible tablets The sample 3.

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PUM

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Abstract

The invention relates to a licorice flavonoid dispersible tablet and its preparation method and application, comprising licorice flavonoids and pharmaceutical excipients; the prescription of the dispersible tablet in parts by weight consists of the following components: 20-40 parts of licorice flavonoids, microcrystalline fiber 30-50 parts of vegetarian food, 5-10 parts of croscarmellose sodium, 3-8 parts of crospovidone, 2-3 parts of 5%-8% povidone solution, magnesium stearate 0.5‑1 part, 1‑3 part of phospholipid. The invention also provides a preparation method and application of the licorice flavone dispersible tablet. The licorice flavone dispersible tablet prepared by the preparation method provided by the invention has stable quality, fast drug release, improved bioavailability, and is suitable for preventing and treating gastric ulcer and duodenal ulcer.

Description

technical field [0001] The invention relates to the technical field of preparation and application of preparations for treating stomach diseases, in particular to a licorice flavonoid dispersible tablet and a preparation method and application thereof. Background technique [0002] Ulcer disease or peptic ulcer is a common digestive tract disease that can occur in the esophagus, stomach or duodenum, and is most common in gastric ulcers and duodenal ulcers, so the so-called peptic ulcer generally refers to Gastric and duodenal ulcers. [0003] With the improvement of our country's national economic level, people's dietary structure and lifestyle have undergone tremendous changes, and work pressure has also increased day by day. Irregular diet or preference for irritating tastes, staying up late, drinking, and other bad eating habits often occur. And these factors all can cause chronic gastritis and peptic ulcer disease, and the sick crowd is increasing day by day. [0004] ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/24A61K36/484A61P1/04
CPCA61K9/2013A61K36/484
Inventor 黄德浩黄辉球黄丽玲黄林华
Owner 惠州市九惠制药股份有限公司
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