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Compound sulfa-nitazoxanide soluble powder for pigs and poultry

A sulfanitazoxanide and soluble technology, which is applied in the field of compound sulfazoxanide soluble powder for pigs and poultry, can solve the problems of poor solubility in water, poor curative effect, and easy solubility in alkali, etc., and achieve the reduction of drug-resistant strains, Effect of antibacterial action improvement, antibacterial action enhancement

Active Publication Date: 2016-10-12
洛阳市兽药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the invention is to overcome the deficiencies in the prior art, to provide a kind of soluble powder of compound sulfanitazoxanide for pigs and poultry, which can make up the shortcoming that sulfonamides are ineffective to anaerobic bacteria when coccidioides mixed with anaerobic bacteria infection, and has the function of preventing And the good effect of treating poultry protozoa infection and mixed infection of protozoa and bacteria, and effective for drug-resistant coccidia infection with poor or ineffective sulfonamide efficacy. The disadvantage of nitazoxanide is that it is insoluble in water and easily soluble in alkali. Co-solvent to improve its water solubility, adding stabilizer to improve its stability, administration through drinking water, easy to use, good effect in prevention and treatment of poultry protozoa infection and mixed infection of protozoa and bacteria

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In the first step, nitazoxanide and sodium carbonate are mixed and stirred evenly in a step-by-step manner to obtain a mixture A, and then the prepared mixture A is added to sulfamethoxine sodium to obtain a mixture B, which is set aside;

[0020] In the second step, mix and stir sodium EDTA2 and TMP sodium evenly to obtain mixture C, then stir the prepared mixture C and mixture B at room temperature to obtain mixture D, and set aside; finally add the prepared mixture D to the auxiliary material Stir and mix uniformly at room temperature to prepare mixture E, which is set aside;

[0021] In the third step, the prepared mixture E is directly sieved or crushed and then sieved, and the sieve is 60-80 mesh, and packed in 100g packaging bags, and the finished product is obtained after sealing.

Embodiment 2

[0023] In the first step, nitazoxanide and sodium benzoate are mixed and stirred evenly in a step-by-step manner to obtain a mixture A, and then the prepared mixture A is added to sulfamethoxine sodium to obtain a mixture B, which is set aside;

[0024] In the second step, sodium sulfite and TMP sodium are mixed and stirred evenly to obtain mixture C, and then the prepared mixture C and mixture B are stirred evenly at room temperature to obtain mixture D for later use; finally, the prepared mixture D is added to the auxiliary materials Stir and mix evenly at room temperature to prepare mixture E and set aside;

[0025] In the third step, the prepared mixture E is directly sieved or crushed and then sieved, and the sieve is 60-80 mesh, and packed in 150g packaging bottles, and the finished product is obtained after pressing the cap.

Embodiment 3

[0027] In the first step, nitazoxanide and sodium citrate are mixed and stirred evenly in a step-by-step manner to obtain a mixture A, and then the prepared mixture A is added to sulfachlorpyrazine sodium to obtain a mixture B, which is set aside;

[0028] In the second step, mix and stir the calcium sodium edetate and TMP sodium evenly to obtain a mixture C, and then stir the prepared mixture C and mixture B at room temperature to obtain a mixture D for subsequent use; finally the prepared mixture D Add it to the auxiliary materials and stir and mix evenly at room temperature to prepare mixture E, which is set aside;

[0029] In the third step, the prepared mixture E is directly sieved or crushed and then sieved, and the sieve is 60-80 mesh, and 200 g is divided into packaging bags, and the finished product is obtained after sealing.

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PUM

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Abstract

The invention provides compound sulfa-nitazoxanide soluble powder for pigs and poultry. The soluble powder is prepared from the following components: 20-30g of sulfa-drugs, 4-10.0g of TMP sodium, 1.5-5g of nitazoxanide, 5-25g of a co-solvent and 1-7.5g of a stabilizing agent, and the total amount after the components and auxiliaries are mixed is 100g. The soluble powder can be used for overcoming the defect that sulfa-drugs are invalid to anaerobic bacteria during infection of coccidium mixed with anaerobic bacteria, has excellent effects in preventing and treating protozoon infection and mixed infection of protozoon and bacteria of pigs and poultry, and is valid to drug-resistance coccidium infection which is poor or invalid to sulfa-drugs; nitazoxanide has the defects of water insolubility and alkali solubility, while the co-solvent can be used for improving the water solubility of nitazoxanide, and the stability of nitazoxanide can be improved by adding the stabilizing agent. The compound sulfa-nitazoxanide soluble powder is administrated by drinking, is convenient to use, and has excellent effects on preventing and treating protozoon infection and mixed infection of protozoa and bacteria of pigs and poultry.

Description

technical field [0001] The invention relates to medicines in the technical field of veterinary medicines, in particular to a compound sulfanitazoxanide soluble powder for pigs and poultry. Background technique [0002] Sulfonamides belong to chemically synthesized broad-spectrum antibacterial agents, which are insoluble in water and easily soluble in alkaline solution. Existing drugs play an antibacterial role by competing with p-aminobenzoic acid for dihydrofolate synthase, thereby hindering the synthesis of folic acid in sensitive bacteria. Higher animals can directly utilize exogenous folic acid, so its metabolism is not interfered by sulfa drugs. It is effective against most Gram-positive bacteria and some Gram-negative bacteria, and it is also effective against coccidia, leukoplasma gallinarum, Toxoplasma gondii, etc., but has no effect on spirochetes, Rickettsia, Mycobacterium tuberculosis, etc. After years of extensive use, bacteria and coccidia tend to develop resi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K31/505A61K31/426A61K9/14A61P31/04A61P33/02
CPCA61K9/0095A61K9/145A61K31/426A61K31/505A61K31/635A61K2300/00
Inventor 胡涵张义仁魏迎军李润乐
Owner 洛阳市兽药厂
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