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A kind of hydrogel@gold nanocomposite material and its preparation method and application

A composite material, gold nanotechnology, applied in analytical materials, nanotechnology, microsphere preparation, etc., can solve the problems of small enhancement of SERS effect, low SERS detection sensitivity, and limited ability to detect low-concentration molecules, so as to improve detection. ability, enhanced SERS effect, enhanced effect of mutual coupling ability

Active Publication Date: 2019-07-02
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the technical problems of the existing SERS matrix structure materials, such as small SERS effect enhancement, low SERS detection sensitivity, and limited ability to detect low-concentration molecules, the present invention provides a hydrogel@gold nanocomposite material Its preparation method and application not only have a stable structure, can effectively play the characteristics of gold nanomaterials and hydrogels, but also can enhance the mutual coupling ability between "hot spots", thereby greatly enhancing the SERS effect and improving the sensitivity of SERS detection , to improve the ability to detect low-concentration molecules

Method used

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  • A kind of hydrogel@gold nanocomposite material and its preparation method and application
  • A kind of hydrogel@gold nanocomposite material and its preparation method and application
  • A kind of hydrogel@gold nanocomposite material and its preparation method and application

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preparation example Construction

[0037] Specifically, the preparation method of the hydrogel@gold nanocomposite material may include the following steps:

[0038] Step A, using microfluidic chip technology to prepare P(AAm-co-AAc) hydrogel with a diameter of 5-200 μm (AAm means acrylamide, AAc means acrylic acid, P(AAm-co-AAc) means acrylamide-acrylic acid copolymer) microspheres. Further, this step A may include the following steps:

[0039] Step A1. According to the ratio of first component: dimethyl sulfoxide = 0.30 ~ 0.33g: 1ml, dissolve the first component in dimethyl sulfoxide to prepare photoinitiator dimethyl sulfoxide solution . Wherein, the first component is 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone.

[0040] Step A2, according to the ratio of water: acrylamide: acrylic acid: N, N-methylenebisacrylamide: photoinitiator dimethyl sulfoxide solution = 1ml: 0.2g: 600μL: 0.007g: 30μL, water, propylene Amide, acrylic acid, N,N-methylenebisacrylamide are mixed with the photoinitiato...

Embodiment 1

[0065] A hydrogel@gold nanocomposite material prepared by the following steps:

[0066] Step a, according to the ratio of the first component: dimethyl sulfoxide = 0.30 ~ 0.33g: 1ml, the first component is dissolved in dimethyl sulfoxide to prepare the photoinitiator dimethyl sulfoxide solution . Wherein, the first component is 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone.

[0067] Step b, according to the ratio of water: acrylamide: acrylic acid: N, N-methylenebisacrylamide: photoinitiator dimethyl sulfoxide solution = 1ml: 0.2g: 600μL: 0.007g: 30μL, water, propylene Amide, acrylic acid, N, N-methylenebisacrylamide and the photoinitiator dimethyl sulfoxide solution prepared in step a are mixed to prepare a P(AAm-co-AAc) hydrogel reaction solution.

[0068] Step c. According to the ratio of liquid paraffin:polyether-modified silicone oil KF-6038=100ml:1-3ml, liquid paraffin and polyether-modified silicone oil KF-6038 are mixed to obtain an oily liquid.

[00...

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Abstract

The invention discloses a hydrogel@gold nanocomposite and a preparation method and application thereof. The hydrogel@gold nanocomposite is composed of one or more core-shell structure units, and each core-shell structure unit is of a core-shell structure with hydrogel microspheres serving as the core and a gold nanosphere layer serving as the shell. The diameter of each gold nanosphere is 30-60 nm, and the diameter of each hydrogel microsphere is 5-200 micrometers. The preparation method includes the steps that the microfluidic chip technology is adopted to prepare the P(AAm-co-AAc) hydrogel microspheres; chloroauric acid is reduced in ethanediol to prepare the gold nanospheres; the gold nanospheres are transferred into water and mixed with the P(AAm-co-AAc) hydrogel microspheres, the mixture is subjected to standing for 12-48 h, and the hydrogel@gold nanocomposite is obtained. According to the hydrogel@gold nanocomposite and the preparation method and application thereof, the properties of a gold nanomaterial and hydrogel can be effectively exerted, the SERS effect can be substantially enhanced, and the sensitivity of SERS detection can be improved, and the detection capability on low-concentration molecules can be improved.

Description

technical field [0001] The invention relates to the field of organic-inorganic core-shell nanocomposite materials, in particular to a hydrogel@gold nanocomposite material and its preparation method and application. Background technique [0002] Core-shell structure materials are generally composed of a central core and an outer shell, usually expressed in the form of "a@b", where a represents the core material, and b represents the shell material, for example: Ag@SiO 2 Indicates that Ag nanoparticles are used as nuclei and SiO 2 Nanomaterials for the shell. Composite materials with core-shell structure have different core-shell combinations, such as: organic-inorganic, inorganic-inorganic, organic-organic, semiconductor-metal, organic-metal, etc. [0003] Noble metal nanomaterials (noble metals mainly refer to eight metal elements including gold, silver, ruthenium, rhodium, palladium, platinum, osmium, and iridium) can strongly absorb and scatter photons, so they have some...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65B01J13/02B82Y30/00B82Y40/00
CPCB01J13/02B82Y30/00B82Y40/00G01N21/658
Inventor 李越李桧林门丹丹孙一强李昕扬蔡伟平
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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